The CHA(2)DS(2)-VASc Score Reflects Clinical Outcomes in Nonvalvular Atrial Fibrillation Patients with an Initial Cardioembolic Stroke

Prestroke CHA2DS2-VASc Score and Severity of Acute Stroke in Patients with Atrial Fibrillation: Findings from RAF Study

“…Whereas, several past studies were retrospective and used only a single assessment score [2][3][4][12][13][14] .…”

“…In retrospective studies CHA2DS2-VASc score have been suggested as a predictor of severity of stroke at admission and poor outcome [2][3][4] .…”

Greater Severity of Neurological Defects in Women Admitted With Atrial Fibrillation-Related Stroke

“…Increased CHADS2 and CHA2DS2-VASc scores positively correlated with the NIHSS score at admission (ρ=0.079; P<0.001 and ρ=0.145; P<0.001, respectively). The initial neurological deficits were more severe in women than in men (NIHSS score, median [IQR] 12 [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] vs. 7 [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]; P<0.001). Multiple regression analysis revealed that higher age (β 0.153; P<0.001), female sex (β 0.112; P<0.001), dyslipidemia (β −0.064; P<0.001), congestive heart failure (β 0.029; P=0.003), vascular disease (β 0.020; P=0.041) and prior anticoagulant use (β −0.033; P=0.001) were associated with the NIHSS score at admission ( Table 2).…”

“…10, 11 The magnitude of the CHADS2 and the CHA2DS2-VASc scores is also associated with initial stroke severity and the likelihood of poor stroke outcomes. 12- 14 An association between sex and initial stroke severity in AF-related cardioembolic patients has not been clarified. The present study aimed to elucidate the association between initial stroke severity, sex difference and clinical risk factors in patients with cardioembolic stroke, based on a computerized database derived from the 94 hospitals that treated stroke patients included in the multicenter Japan Standard Stroke Registry Study (JSSRS).…”

Pre-admission CHADS2, CHA2DS2-VASc, and R2CHADS2 Scores on Severity and Functional Outcome in Acute Ischemic Stroke with Atrial Fibrillation

“…7 The pre-admission CHADS 2 score was associated with long-term mortality after stroke, 8 early neurologic deterioration in stroke patients with nonvalvular AF, 9 and severity and functional outcome of AF-related cardioembolic stroke. 10,11 Furthermore, the pre-admission CHA 2 DS 2 -VASc score was associated with a 3-month outcome in patients with ischemic stroke with AF, 12,13 whereas the CHA 2 DS 2 -VASc score was better than CHADS 2 for estimating 3-month stroke outcomes. 14 Similarly, the pre-admission R 2 CHADS 2 score is considered a good predictive tool for ischemic stroke with AF.…”