Pre-admission CHADS2, CHA2DS2-VASc, and R2CHADS2 Scores on Severity and Functional Outcome in Acute Ischemic Stroke with Atrial Fibrillation

Tanaka, Kõji; Yamada, Takeshi; Torii, Takako; Furuta, Konosuke; Matsumoto, Shoji; Yoshimura, Teizo; Takase, Kei‐ichiro; Wakata, Yoshifumi; Nakashima, Naoki; Kira, Jun Ichi; Murai, Hiroyuki

doi:10.1016/j.jstrokecerebrovasdis.2015.03.036

Cited by 29 publications

(26 citation statements)

References 32 publications

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“…These risk stratification schemes may also be useful for predicting clinical outcomes in ischemic stroke or transient ischemic attack (TIA) patients with AF. In fact, we [4, 5] and others [6-9] have reported positive associations between pre-admission CHADS 2 and CHA 2 DS 2 -VASc scores and poor clinical outcomes in ischemic stroke patients with AF. In these studies, however, clinical outcomes were assessed at ≤3 months.…”

Section: Introductionmentioning

confidence: 90%

Associations between Pre-Admission Risk Scores and Two-Year Clinical Outcomes in Ischemic Stroke or Transient Ischemic Attack Patients with Non-Valvular Atrial Fibrillation

et al. 2018

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Background: We aimed to clarify associations between pre-admission risk scores (CHADS₂, CHA₂DS₂-VASc, and HAS-BLED) and 2-year clinical outcomes in ischemic stroke or transient ischemic attack (TIA) patients with non-valvular atrial fibrillation (NVAF) using a prospective, multicenter, observational registry. Methods: From 18 Japanese stroke centers, ischemic stroke or TIA patients with NVAF hospitalized within 7 days after onset were enrolled. Outcome measures were defined as death/disability (modified Rankin Scale score ≥3) at 2 years, 2-year mortality, and ischemic or hemorrhagic events within 2 years. Results: A total of 1,192 patients with NVAF (527 women; mean age, 78 ± 10 years), including 1,141 ischemic stroke and 51 TIA, were analyzed. Rates of death/disability, mortality, and ischemic or hemorrhagic events increased significantly with increasing pre-admission CHADS₂ (p for trend <0.001 for death/disability and mortality, p for trend = 0.024 for events), CHA₂DS₂-VASc (p for trend <0.001 for all), and HAS-BLED (p for trend = 0.004 for death/disability, p for trend <0.001 for mortality, p for trend = 0.024 for events) scores. Pre-admission CHADS₂ (OR per 1 point, 1.52; 95% CI 1.35–1.71; p <0.001 for death/disability; hazard ratio (HR) per 1 point, 1.23; 95% CI 1.12–1.35; p <0.001 for mortality; HR per 1 point, 1.14; 95% CI 1.02–1.26; p = 0.016 for events), CHA₂DS₂-VASc (1.55, 1.41–1.72, p < 0.001; 1.21, 1.12–1.30, p < 0.001; 1.17, 1.07–1.27, p < 0.001; respectively), and HAS-BLED (1.33, 1.17–1.52, p < 0.001; 1.23, 1.10–1.38, p < 0.001; 1.18, 1.05–1.34, p = 0.008; respectively) scores were independently associated with all outcome measures. Conclusions: In ischemic stroke or TIA patients with NVAF, all pre-admission risk scores were independently associated with death/disability at 2 years and 2-year mortality, as well as ischemic or hemorrhagic events within 2 years.

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Section: Introductionmentioning

confidence: 90%

Associations between Pre-Admission Risk Scores and Two-Year Clinical Outcomes in Ischemic Stroke or Transient Ischemic Attack Patients with Non-Valvular Atrial Fibrillation

et al. 2018

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“…Whereas, several past studies were retrospective and used only a single assessment score [2][3][4][12][13][14] .…”

Section: Discussionmentioning

confidence: 99%

Prestroke CHA2DS2-VASc Score and Severity of Acute Stroke in Patients with Atrial Fibrillation: Findings from RAF Study

Acciarresi

Paciaroni

Agnelli

et al. 2017

Journal of Stroke and Cerebrovascular Diseases

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Acciarresi, M. et al. (2017) Prestroke CHA2DS2-VASc score and severity of acute stroke in patients with atrial fibrillation: findings from RAF study. Journal of Stroke and Cerebrovascular Diseases, 26(6), pp. 1363-1368. (10.1016/j.jstrokecerebrovasdis.2017 There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.http://eprints.gla.ac.uk/138063/ AbstractBackground and Purpose: The aim of this study was to investigate for a possible

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“…The present study used a prospective, observational, multicenter database, which is part of the broad‐area, network‐based, project to drive clinical research at Kyushu University Hospital. The methods of this study have been previously described in detail . Briefly, this study enrolled consecutive patients with ischemic stroke admitted to three affiliated hospitals with a stroke unit (Saiseikai Fukuoka General Hospital, Fukuoka City Hospital and Iizuka Hospital) within 7 days of symptom onset.…”

Section: Methodsmentioning

confidence: 99%

Clinical characteristics of atrial fibrillation‐related cardioembolic stroke in patients aged 80 years or older

Tanaka

Yamada

Torii

et al. 2016

Geriatrics Gerontology Int

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Pre-admission CHADS2, CHA2DS2-VASc, and R2CHADS2 Scores on Severity and Functional Outcome in Acute Ischemic Stroke with Atrial Fibrillation

Cited by 29 publications

References 32 publications

Associations between Pre-Admission Risk Scores and Two-Year Clinical Outcomes in Ischemic Stroke or Transient Ischemic Attack Patients with Non-Valvular Atrial Fibrillation

Associations between Pre-Admission Risk Scores and Two-Year Clinical Outcomes in Ischemic Stroke or Transient Ischemic Attack Patients with Non-Valvular Atrial Fibrillation

Prestroke CHA2DS2-VASc Score and Severity of Acute Stroke in Patients with Atrial Fibrillation: Findings from RAF Study

Clinical characteristics of atrial fibrillation‐related cardioembolic stroke in patients aged 80 years or older

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