The cervical spinal cord in neuromyelitis optica patients: A comparative study with multiple sclerosis using diffusion tensor imaging

Pessôa, Fernanda Miraldi Clemente; Lopes, Fernanda Cristina Rueda; Costa, João Victor Altamiro; Leon, Soniza Vieira Alves; Domingues, Romeu Côrtes; Gasparetto, Emerson L.

doi:10.1016/j.ejrad.2011.11.026

Cited by 16 publications

(12 citation statements)

References 19 publications

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“…LESCLs in anti‐AQP4 antibody‐seropositive NMO cases were preferentially present in the central gray matter on MRI , which is explained by the greater abundance of AQP4 antigen in the gray matter compared with the white matter . However, diffusion tensor imaging of the spinal cord demonstrated white matter damage . Our 3‐tesla MRI study of the fine distribution of early LESCLs demonstrated that the spinal white matter, especially the PC and LC, can be involved as frequently as the gray matter in the relatively early stages of disease, regardless of anti‐AQP4 antibody status, whereas gray matter involvement was more common in anti‐AQP4 antibody‐seropositive LESCLs than in seronegative LESCLs.…”

Section: Discussionmentioning

confidence: 77%

Early and extensive spinal white matter involvement in neuromyelitis optica

Hayashida¹,

Kitajima²,

Yonekawa³

et al. 2016

Brain Pathology

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Section: Discussionmentioning

confidence: 77%

Early and extensive spinal white matter involvement in neuromyelitis optica

Hayashida¹,

Kitajima²,

Yonekawa³

et al. 2016

Brain Pathology

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“…Nontraumatic pathology affecting the spinal cord can lead to symptoms of ataxia because of a disturbance in proprioception and motor function. Processes include inflammatory and demyelinating diseases [94], such as multiple sclerosis [95][96][97][98][99][100][101][102][103][104], neuromyelitis optica [105][106][107][108][109][110][111][112], and acute disseminated encephalomyelitis [54]. Other inflammatory causes, such as neurosarcoidosis [113]; neoplasms such as lymphoma [114] and metastases as well as paraneoplastic syndromes [115]; nutritional deficiencies, such as B12 deficiency [116] and copper deficiency; infections affecting the cord, such as neurosyphilis; degenerative changes in the vertebral bodies and discs [117,118]; or ossification of the posterior longitudinal ligament [119] that lead to cord compression and edema.…”

Section: Discussion Of Procedures By Variantmentioning

confidence: 99%

ACR Appropriateness Criteria® Ataxia

Juliano

Policeni

Agarwal

et al. 2019

Journal of the American College of Radiology

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Ataxia can result from an abnormality in the cerebellum, spinal cord, peripheral nerves, and/or vestibular system. Pathology involving the brain, such as infarct or hydrocephalus, can also present with ataxia as part of the symptom constitution, or result in symptoms that mimic ataxia. Clinical evaluation by history and careful neurological examination is important to help with lesion localization, and helps determine where imaging should be focused. In the setting of trauma with the area of suspicion in the brain, a head CT without intravenous contrast is the preferred initial imaging choice. If vascular injury is suspected, CTA of the neck can be helpful. When the area of suspicion is in the spine, CT or MRI of the spine can be considered to assess for bony or soft-tissue injury, respectively. In the setting of ataxia unrelated to recent trauma, MRI is the preferred imaging modality, tailored to assess the brain or spine depending on the area of suspected pathology. The use of intravenous contrast is generally helpful.

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“…3,4 Therefore, the anterior horn is damaged and neuronopathy occurs. 5 The dysfunction in NMO is more severe than that in MS because of the severe disorganization and greater extent of the lesion. 2,4 This case presented with an extensive MRI lesion spanning most of the spinal cord in the acute phase and from T6 to T10 level in the chronic phase.…”

Section: Discussionmentioning

confidence: 99%

Rehabilitation for paraplegia caused by neuromyelitis optica: a case report

et al. 2014

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Study design: Single case report.Objective: We present a case of paraplegia due to neuromyelitis optica (NMO) with poor rehabilitation outcome. Setting: University hospital, Japan. Case report: A 27-year-old woman with NMO presented with T5 paraplegia of ASIA impairment scale grade A. Spinal cord magnetic resonance imaging revealed a lesion spanning C3 to L1 level. After acute phase treatment, flaccid paraplegia below T5 and a T2-weighted hyperintense lesion from T6 to T10 level remained. Rehabilitation aimed at independence of activities of daily living with wheelchair assistance, including transfer activity, was provided for 19 months. However, flaccid paralysis of the trunk and limbs persisted, and safe independent transfer was not achieved. Conclusion: Spinal lesions spanning many vertebral segments, a characteristic of NMO, can cause extensive flaccid paralysis of the trunk and limbs. Rehabilitation may achieve poorer functional recovery than that for spinal cord injury.

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The cervical spinal cord in neuromyelitis optica patients: A comparative study with multiple sclerosis using diffusion tensor imaging

Cited by 16 publications

References 19 publications

Early and extensive spinal white matter involvement in neuromyelitis optica

Early and extensive spinal white matter involvement in neuromyelitis optica

ACR Appropriateness Criteria® Ataxia

Rehabilitation for paraplegia caused by neuromyelitis optica: a case report

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