The cerebral blood distribution in dogs and cats. An anatomical and functional study

Wellens, D; Wouters, L; Reese, Rita J.J. De; Beirnaert, P.; Reneman, Robert S.

doi:10.1016/0006-8993(75)90893-8

Cited by 50 publications

(23 citation statements)

References 20 publications

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“…In cats, a well-developed rete mirabile is present in the carotid circulation so that blood flowing to the cerebrum must first traverse this structure (Holmes et al 1958;Hayward & Baker, 1969;Wellens et al 1975). Direct measurements of blood flow and pressure in goats suggest that the resistance of a rete is sufficient to produce a significant pressure decrease across the rete (Lluch, Dieguez, Garcia & Gomez, 1985).…”

Section: Brain Stem Blood Flow Segmental Resistance Under Control Conmentioning

confidence: 99%

“…In many mammals, including cats, the cerebrum receives most of its blood supply via the carotid circulation, and the vertebro-basilar circulation supplies primarily the cerebellum and brain stem (Holmes, Newman & Wolstencroft, 1958;Wellens, Wouters, De Reese, Beirnaert, & Reneman, 1975). Previously, it was not possible to determine if the contribution of large arteries to the total resistance was similar in the cerebrum and brain stem.…”

Section: Brain Stem Blood Flow Segmental Resistance Under Control Conmentioning

confidence: 99%

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Role of large arteries in regulation of blood flow to brain stem in cats.

Faraci

Heistad

Mayhan

1987

The Journal of Physiology

103

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SUMMARY1. The goal of this study was to examine the regulation of resistance in the large arteries and small vessels that supply the brain stem.2. We used a new method in anaesthetized cats to measure blood flow to the medulla (microspheres) and pressure (servo-null) in branches of the basilar artery that supply the medulla. Resistance was determined during normocapnia, hypercapnia, hypocapnia and seizures (produced with intravenous bicuculline).3. Pressure in arteries that supply the medulla (150 ,sm internal diameter) was 71+4% (mean+S.E. of mean) of aortic pressure and large artery resistance was 31 + 4 % of the total resistance in the medulla. Hypercapnia and seizures decreased large artery resistance by 67 and 50 %, respectively, and hypocapnia increased large artery resistance by 58 %. Small vessel resistance decreased by 82 % during hypercapnia and by 43 % during seizures, and increased by 96 % during hypocapnia.4. Thus, resistance of the large arteries (> 150 ,um diameter) accounts for about one-third of the total vascular resistance in the brain stem. Both large arteries and small vessels respond to alterations in arterial carbon dioxide tension and seizures, and contribute to the regulation of blood flow to the brain stem.

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Section: Brain Stem Blood Flow Segmental Resistance Under Control Conmentioning

confidence: 99%

Section: Brain Stem Blood Flow Segmental Resistance Under Control Conmentioning

confidence: 99%

Role of large arteries in regulation of blood flow to brain stem in cats.

Faraci

Heistad

Mayhan

1987

The Journal of Physiology

103

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“…15 Third, the basilar artery has been shown to provide a significant amount of blood flow to the canine cerebral parenchyma. 16 The basilar artery for the canine is approximately 1 mm or less in diameter, which makes it difficult to define the region of interest for the input function in such a way where there is no partial volume effect. To keep the partial volume effects similar between C-arm CT and PCT, the spatial resolution of the reconstructions was kept as similar as possible between the 2 modalities (0.5 mm and 0.6 mm for C-arm and PCT, respectively).…”

Section: Perfusion Data Processingmentioning

confidence: 99%

C-Arm CT Measurement of Cerebral Blood Volume and Cerebral Blood Flow Using a Novel High-Speed Acquisition and a Single Intravenous Contrast Injection

Royalty¹,

Manhart

Pulfer

et al. 2013

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Assessment of perfusion parameters is important in the selection of patients who are most likely to benefit from revascularization after an acute ischemic stroke. The aim of this study was to evaluate the feasibility of measuring cerebral perfusion parameters with the use of a novel high-speed C-arm CT acquisition in conjunction with a single intravenous injection of contrast.

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“…They injected CO, saturated saline into either the vertebral or the internal maxillary artery in anesthetized cats and showed that the excitation of the central chemoreceptor was produced by the vertebral artery injection. Furthermore, Wellens et al (1975) have reported that, with the radioactive microsphere method, the medulla was predominantly perfused via the vertebral artery. Thus, there is no doubt that the central chemoreceptor for respiration located in the medulla.…”

Section: Discussionmentioning

confidence: 99%