The Cerebellar Cognitive Affective Syndrome—a Meta-analysis

Ahmadian, Narjes; Baarsen, Kirsten van; Zandvoort, Martine van; Robe, Pierre A.

doi:10.1007/s12311-019-01060-2

Cited by 89 publications

(60 citation statements)

References 47 publications

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“…All participants provided written informed consent for participation in this study. The study was approved by the Medical Research Ethics Board, University of Oldenburg, Germany (2017-059) and was preregistered with the German Clinical Trials Register (DRKS00012791) 1 . MR images of the entire brain were acquired in the Neuroimaging Unit, School of Medicine and Health Sciences, University of Oldenburg 2 , on a research-only Siemens MAG-NETOM Prisma whole-body scanner (Siemens, Erlangen, Germany) at 3 Tesla with a 64-channel head/neck receivearray coil.…”

Section: Methodsmentioning

confidence: 99%

“…Long-term reproducibility, finally, is assessed by analyzing two MRI scans of the same participant in a longitudinal study. We decided to test the following three software packages: (1) FreeSurfer, an established and widely used approach of subcortical segmentation, based on a probabilistic atlas, which performs cerebellar segmentation, but not parcellation (23), (2) CERES, a recent segmentation and parcellation method based on a multiatlas label fusion technique (20), the most accurate software tool in the comparison by Carass et al (19), and (3) ACA-PULCO, a very recent and promising parcellation approach based on convolutional neural networks (24), not included in the comparison by Carass et al (19). In a separate paper, the developers of ACAPULCO demonstrated comparable accuracy of their software relative to CERES for adult data and even superior accuracy in several regions for pediatric data (24).…”

Section: Introductionmentioning

confidence: 99%

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Replicability, repeatability, and long-term reproducibility of cerebellar morphometry

Sörös

Wölk

Bantel

et al. 2020

Preprint

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To identify robust and reproducible methods of cerebellar morphometry that can be used in future large-scale structural MRI studies, we investigated the replicability, repeatability, and long-term reproducibility of three fully-automated software tools: FreeSurfer, CERES, and CNN. Replicability was defined as computational replicability, determined by comparing two analyses of the same high-resolution MRI data set performed with identical analysis software and computer hardware. Repeatability was determined by comparing the analyses of two MRI scans of the same participant taken during two independent MRI sessions on the same day for the Kirby-21 study. Long-term reproducibility was assessed by analyzing two MRI scans of the same participant in the longitudinal OASIS-2 study. We determined percent difference, the image intraclass correlation coefficient, the coefficient of variation, and the intraclass correlation coefficient between two analyses. Our results show that CERES and CNN use stochastic algorithms that result in surprisingly high differences between identical analyses for CNN and small differences for CERES. Changes between two consecutive scans from the Kirby-21 study were less than ±5% in most cases for FreeSurfer and CERES (i.e., demonstrating high repeatability). As expected, long-term reproducibility was lower than repeatability for all software tools. In summary, CERES is an accurate, as demonstrated before, and reproducible tool for fully-automated segmentation and parcellation of the cerebellum. We conclude with recommendations for the assessment of replicability, repeatability, and long-term reproducibility in future studies on cerebellar structure.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Replicability, repeatability, and long-term reproducibility of cerebellar morphometry

Sörös

Wölk

Bantel

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

Section: Replicability: Chropain2 Studymentioning

confidence: 99%

“…Physiology and pathophysiology of the cerebellum have received growing attention in basic and clinical neurosciences [1][2][3]. Early nineteenth century neuroscientists, especially Luigi Rolando and Pierre Flourens, have established the crucial role of the cerebellum in motor control [4] and, more specifically, motor coordination [5].…”

Section: Introductionmentioning

confidence: 99%

Replicability, Repeatability, and Long-term Reproducibility of Cerebellar Morphometry

et al. 2021

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To identify robust and reproducible methods of cerebellar morphometry that can be used in future large-scale structural MRI studies, we investigated the replicability, repeatability, and long-term reproducibility of three fully automated software tools: FreeSurfer, CEREbellum Segmentation (CERES), and automatic cerebellum anatomical parcellation using U-Net with locally constrained optimization (ACAPULCO). Replicability was defined as computational replicability, determined by comparing two analyses of the same high-resolution MRI data set performed with identical analysis software and computer hardware. Repeatability was determined by comparing the analyses of two MRI scans of the same participant taken during two independent MRI sessions on the same day for the Kirby-21 study. Long-term reproducibility was assessed by analyzing two MRI scans of the same participant in the longitudinal OASIS-2 study. We determined percent difference, the image intraclass correlation coefficient, the coefficient of variation, and the intraclass correlation coefficient between two analyses. Our results show that CERES and ACAPULCO use stochastic algorithms that result in surprisingly high differences between identical analyses for ACAPULCO and small differences for CERES. Changes between two consecutive scans from the Kirby-21 study were less than ± 5% in most cases for FreeSurfer and CERES (i.e., demonstrating high repeatability). As expected, long-term reproducibility was lower than repeatability for all software tools. In summary, CERES is an accurate, as demonstrated before, and reproducible tool for fully automated segmentation and parcellation of the cerebellum. We conclude with recommendations for the assessment of replicability, repeatability, and long-term reproducibility in future studies on cerebellar structure.

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“…The cerebellar midline region, including the fastigial nucleus, has been recognized to be critically involved in the cerebellar cognitive affective syndrome, a heterogeneous clinical condition described after cerebellar injuries in adults concerning the cognitive-associative, visuospatial, and affective domain [1,2]. This anatomical region is also discussed in the context of the cerebellar mutism syndrome, which is observed in children after posterior fossa midline tumor resection, and certain neuropsychiatric disorders, including autism spectrum disorders and schizophrenia [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Regulation of Neural Transmission after Cerebellar Fastigial Nucleus Lesions in Juvenile Rats

et al. 2021

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Structural and functional abnormalities in the cerebellar midline region, including the fastigial nucleus, have been reported in neuropsychiatric disorders, also comprising the cerebellar cognitive affecting syndrome. In rats, early fastigial lesions reduce social interaction during development and lead to cognitive and emotional deficits in adults, accompanied by compromised neuronal network activity. Since epigenetic mechanisms are implicated in the etiology of neuropsychiatric disorders, we investigated whether fastigial nucleus lesions in juvenile rats would impact epigenetic regulation of neural transmission. The fastigial nucleus was lesioned bilaterally in 23-day-old male rats. Sham-lesion and naïve rats served as controls. DNA methylation was investigated for target genes of the GABAergic, dopaminergic, glutamatergic and oxytocinergic systems in brain regions with anatomic connections to the fastigial nucleus, i.e., medial prefrontal cortex, nucleus accumbens, striatum, thalamus, and sensorimotor cortex. Protein expression was examined for the respective target genes in case of altered DNA methylation between lesion and control groups. Lesioning of the fastigial nucleus led to significant differences in the epigenetic regulation of glutamate decarboxylase 1 and the oxytocin receptor in the nucleus accumbens and the prefrontal cortex. No differences were found for the other target genes and brain regions. Our findings indicate that epigenetic dysregulation after lesioning of the fastigial nucleus may influence long-term recovery and the emergence of behavioral changes. Together with previous behavioral and electrophysiological investigations of this rat model, these observations can play a role in the cerebellar cognitive affective syndrome and other neuropsychiatric disorders.

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The Cerebellar Cognitive Affective Syndrome—a Meta-analysis

Cited by 89 publications

References 47 publications

Replicability, repeatability, and long-term reproducibility of cerebellar morphometry

Replicability, repeatability, and long-term reproducibility of cerebellar morphometry

Replicability, Repeatability, and Long-term Reproducibility of Cerebellar Morphometry

Epigenetic Regulation of Neural Transmission after Cerebellar Fastigial Nucleus Lesions in Juvenile Rats

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