Replicability, Repeatability, and Long-term Reproducibility of Cerebellar Morphometry

Sörös, Peter; Wölk, Louise; Bantel, Carsten; Bräuer, Anja U.; Klawonn, Frank; Witt, Karsten

doi:10.1007/s12311-020-01227-2

Cited by 16 publications

(8 citation statements)

References 60 publications

(103 reference statements)

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“…For a larger replication study we recommend to cross-validate effects with different, well-established analysis approaches. The reproducibility of these analysis approaches should be investigated as recommended previously ( Sörös et al, 2021 ). One way to test the repeatability of the experiment and the analysis is to acquire two runs of the same paradigm and to compare the average of single runs before performing the grand average of all runs.…”

Section: Discussionmentioning

confidence: 99%

Functional MRI of Native and Non-native Speech Sound Production in Sequential German-English Bilinguals

Treutler

Sörös

2021

Front. Hum. Neurosci.

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Bilingualism and multilingualism are highly prevalent. Non-invasive brain imaging has been used to study the neural correlates of native and non-native speech and language production, mainly on the lexical and syntactic level. Here, we acquired continuous fast event-related FMRI during visually cued overt production of exclusively German and English vowels and syllables. We analyzed data from 13 university students, native speakers of German and sequential English bilinguals. The production of non-native English sounds was associated with increased activity of the left primary sensorimotor cortex, bilateral cerebellar hemispheres (lobule VI), left inferior frontal gyrus, and left anterior insula compared to native German sounds. The contrast German > English sounds was not statistically significant. Our results emphasize that the production of non-native speech requires additional neural resources already on a basic phonological level in sequential bilinguals.

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Section: Discussionmentioning

confidence: 99%

Functional MRI of Native and Non-native Speech Sound Production in Sequential German-English Bilinguals

Treutler

Sörös

2021

Front. Hum. Neurosci.

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“…We examined volume of the total cerebellum, corpus medullare, 5 vermal regions, and 11 lateralized lobules (left-right averaged), for a total of 18 cerebellar ROIs. We also conducted analyses for the subset of participants with longitudinal data (2 time points) through ACAPULCO version 0.3.0, further optimized for longitudinal analysis …”

Section: Methodsmentioning

confidence: 99%

“…We also conducted analyses for the subset of participants with longitudinal data (2 time points) through ACAPULCO version 0.3.0, further optimized for longitudinal analysis. 4,45 DTI data for 28 ROIs were processed as detailed in our previous publication. 27 Briefly, we used the ENIGMA-DTI pipeline 46 , a modified tract-based spatial statistics approach 47 resulting in FA and other metrics averaged within ROIs from the Johns Hopkins University atlas.…”

Section: Image Acquisition Processing and Quality Controlmentioning

confidence: 99%

Multimodal Analysis of Secondary Cerebellar Alterations After Pediatric Traumatic Brain Injury

Keleher,

Lindsey,

Kerestes

et al. 2023

JAMA Netw Open

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ImportanceTraumatic brain injury (TBI) is known to cause widespread neural disruption in the cerebrum. However, less is known about the association of TBI with cerebellar structure and how such changes may alter executive functioning.ObjectiveTo investigate alterations in subregional cerebellum volume and cerebral white matter microstructure after pediatric TBI and examine subsequent changes in executive function.Design, Setting, and ParticipantsThis retrospective cohort study combined 12 data sets (collected between 2006 and 2020) from 9 sites in the Enhancing Neuroimaging Genetics Through Meta-Analysis Consortium Pediatric TBI working group in a mega-analysis of cerebellar structure. Participants with TBI or healthy controls (some with orthopedic injury) were recruited from trauma centers, clinics, and institutional trauma registries, some of which were followed longitudinally over a period of 0.7 to 1.9 years. Healthy controls were recruited from the surrounding community. Data analysis occurred from October to December 2022.ExposureAccidental mild complicated-severe TBI (msTBI) for those in the TBI group. Some controls received a diagnosis of orthopedic injury.Main Outcomes and MeasuresVolume of 18 cerebellar lobules and vermal regions were estimated from 3-dimensional T1-weighted magnetic resonance imaging (MRI) scans. White matter organization in 28 regions of interest was assessed with diffusion tensor MRI. Executive function was measured by parent-reported scores from the Behavior Rating Inventory of Executive Functioning.ResultsA total of 598 children and adolescents (mean [SD] age, 14.05 [3.06] years; range, 5.45-19.70 years; 386 male participants [64.5%]; 212 female participants [35.5%]) were included in the study, with 314 participants in the msTBI group, and 284 participants in the non-TBI group (133 healthy individuals and 151 orthopedically injured individuals). Significantly smaller total cerebellum volume (d = −0.37; 95% CI, −0.52 to −0.22; P &lt; .001) and subregional cerebellum volumes (eg, corpus medullare; d = −0.43; 95% CI, −0.58 to −0.28; P &lt; .001) were observed in the msTBI group. These alterations were primarily seen in participants in the chronic phase (ie, &gt;6 months postinjury) of injury (total cerebellar volume, d = −0.55; 95% CI, −0.75 to −0.35; P &lt; .001). Smaller cerebellum volumes were associated with higher scores on the Behavior Rating Inventory of Executive Functioning Global Executive Composite score (β = −208.9 mm3; 95% CI, −319.0 to −98.0 mm3; P = .008) and Metacognition Index score (β = −202.5 mm3; 95% CI, −319.0 to −85.0 mm3; P = .02). In a subset of 185 participants with longitudinal data, younger msTBI participants exhibited cerebellum volume reductions (β = 0.0052 mm3; 95% CI, 0.0013 to 0.0090 mm3; P = .01), and older participants slower growth rates. Poorer white matter organization in the first months postinjury was associated with decreases in cerebellum volume over time (β=0.52 mm3; 95% CI, 0.19 to 0.84 mm3; P = .005).Conclusions and RelevanceIn this cohort study of pediatric msTBI, our results demonstrated robust cerebellar volume alterations associated with pediatric TBI, localized to the posterior lobe. Furthermore, longitudinal cerebellum changes were associated with baseline diffusion tensor MRI metrics, suggesting secondary cerebellar atrophy. These results provide further understanding of secondary injury mechanisms and may point to new opportunities for intervention.

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“…Brain morphometry (structural imaging) will be performed using FreeSurfer [ 68 , 69 ] to determine brain total volume, total white matter volume and total grey matter volume. Cerebellum morphometry, performed using ACAPULCO [ 70 ], to determine the total cerebellar volume while SUIT [ 71 ] will be used to calculate the volume of left and right cerebellar peduncles. Brain DTI data will be analysed using FMRIB Software Library (FSL) [ 69 , 72 ] to determine the fractional anisotropy (FAn) and mean, axial and radial diffusivity (MD, AD, RD) of the left and right SCP.…”

Section: Methods and Analysismentioning

confidence: 99%

A natural history study to track brain and spinal cord changes in individuals with Friedreich’s ataxia: TRACK-FA study protocol

et al. 2022

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Introduction Drug development for neurodegenerative diseases such as Friedreich’s ataxia (FRDA) is limited by a lack of validated, sensitive biomarkers of pharmacodynamic response in affected tissue and disease progression. Studies employing neuroimaging measures to track FRDA have thus far been limited by their small sample sizes and limited follow up. TRACK-FA, a longitudinal, multi-site, and multi-modal neuroimaging natural history study, aims to address these shortcomings by enabling better understanding of underlying pathology and identifying sensitive, clinical trial ready, neuroimaging biomarkers for FRDA. Methods 200 individuals with FRDA and 104 control participants will be recruited across seven international study sites. Inclusion criteria for participants with genetically confirmed FRDA involves, age of disease onset ≤ 25 years, Friedreich’s Ataxia Rating Scale (FARS) functional staging score of ≤ 5, and a total modified FARS (mFARS) score of ≤ 65 upon enrolment. The control cohort is matched to the FRDA cohort for age, sex, handedness, and years of education. Participants will be evaluated at three study visits over two years. Each visit comprises of a harmonized multimodal Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) scan of the brain and spinal cord; clinical, cognitive, mood and speech assessments and collection of a blood sample. Primary outcome measures, informed by previous neuroimaging studies, include measures of: spinal cord and brain morphometry, spinal cord and brain microstructure (measured using diffusion MRI), brain iron accumulation (using Quantitative Susceptibility Mapping) and spinal cord biochemistry (using MRS). Secondary and exploratory outcome measures include clinical, cognitive assessments and blood biomarkers. Discussion Prioritising immediate areas of need, TRACK-FA aims to deliver a set of sensitive, clinical trial-ready neuroimaging biomarkers to accelerate drug discovery efforts and better understand disease trajectory. Once validated, these potential pharmacodynamic biomarkers can be used to measure the efficacy of new therapeutics in forestalling disease progression. Clinical trial registration ClinicalTrails.gov Identifier: NCT04349514.

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Replicability, Repeatability, and Long-term Reproducibility of Cerebellar Morphometry

Cited by 16 publications

References 60 publications

Functional MRI of Native and Non-native Speech Sound Production in Sequential German-English Bilinguals

Functional MRI of Native and Non-native Speech Sound Production in Sequential German-English Bilinguals

Multimodal Analysis of Secondary Cerebellar Alterations After Pediatric Traumatic Brain Injury

A natural history study to track brain and spinal cord changes in individuals with Friedreich’s ataxia: TRACK-FA study protocol

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