The Centrilobular Form of Hypertrophic Emphysema and its Relation to Chronic Bronchitis

Leopold, J. G.; Gough, J.

doi:10.1136/thx.12.3.219

Cited by 296 publications

(134 citation statements)

References 10 publications

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“…The tobacco-induced chronic inflammatory reaction may spread centrifugally from the small airways to the adjacent parenchyma and lead to progressive destruction of peribronchiolar alveoli [10]. Some support for this concept has come from the demonstration of a relationship between bronchiolar disease and centriacinar emphysema in previous pathological studies [6,9,11,12]. In addition, physiological studies have shown a link between tobacco-associated bronchiolar disease such as RB and functional abnormalities of the small airways [13,14].…”

Section: Discussionmentioning

confidence: 84%

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Respiratory bronchiolitis in smokers with spontaneous pneumothorax

Cottin

Streichenberger²,

Jp³

et al. 1998

Eur Respir J

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Respiratory bronchiolitis (RB) is defined by the accumulation of pigmented macrophages in the lumen and wall of respiratory and membranous bronchioles of smokers. The aim of this study was to determine whether spontaneous pneumothorax was associated with a high prevalence of RB. Seventy-nine consecutive patients who underwent a surgical procedure (thoracotomy or thoracoscopy) for recurrence or persistence of primary spontaneous pneumothorax despite thoracic drainage were studied retrospectively. RB was found in 70 of 79 (88.6%) smokers operated for spontaneous pneumothorax. Associated interstitial pathological abnormalities were present in 53 of 79 cases (67.1%). In nine patients, the pathological lesions were severe and resembled desquamative interstitial pneumonia. Emphysematous lesions were present in about one-third of the patients. Although the possible pathophysiological consequences of respiratory bronchiolitis remain speculative, this study demonstrates the high prevalence of this pathological abnormality in patients with pneumothorax requiring surgical treatment.

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Section: Discussionmentioning

confidence: 84%

“…Peripheral airway lesions such as RB may be the precursor of more severe anatomical lesions such as centriacinar emphysema [9]. The tobacco-induced chronic inflammatory reaction may spread centrifugally from the small airways to the adjacent parenchyma and lead to progressive destruction of peribronchiolar alveoli [10].…”

Section: Discussionmentioning

confidence: 99%

Respiratory bronchiolitis in smokers with spontaneous pneumothorax

Cottin

Streichenberger²,

Jp³

et al. 1998

Eur Respir J

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“…Thus, chronic particle retention and tissue remodel-ing is common in the central acinus, where centriacinar (or centrilobular) emphysema develops in smokers. 5 Particles Յ0.1 m diameter are referred to as ultrafine and aerodynamically are too small to sediment out during normal breathing; however, they are deposited on alveolar walls by diffusion or are breathed back out again without deposition. They are rapidly removed by a combination of phagocytosis, lymphatic flow toward hilar nodes, and capillary blood flow, and they appear to not be retained in large numbers in the lung parenchyma.…”

Section: Effect Of Differently Sized Particulates On Deposition and Rmentioning

confidence: 99%

Relative Effects of Air Pollution on Lungs and Heart

Johnson

2004

Circulation

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“…It is best classified in relation to the nature of invo1vement of the acinus. bronchioles are quite often narrowed but may be normal (67). It is generally associated with chronic bronchitis when the disease becomes more severe, and it is difficult to appreciate the centrilobular origins of the disease.…”

Section: Classificationmentioning

confidence: 99%

“…-7-Longacre and Johansmann (67), in 1940, reported the effects of pneumonectomy on the residual lung of three young and two adult dogs.…”

Section: Histological Reviewmentioning

confidence: 99%

Experimental Pulmonary Emphysema in Dogs

1963

JAMA

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ABS'IBAC,!:EXPERn~TAL PULMONARY EMPHYSEMA IN DOGS by RUNGSUN PUSHPAKOM, M.D.Varying degrees of panlobular emphysem were produced in 10 dogs by intratracheal injection of papain. Pulmonary function was studied before and after the development of emphyserna. The production of emphysema led to an increase in ERC, RV and TIC of 23%, 24%, and 16% respectively.'fhe arterial oxygen saturation decreased by 8% and the Pao2 by 19 mrnHg.There was no significant effect on the Paco2' pH and bicarbonate. Steady state diffusing capa city was reduced by 55%, compliance increased by 63% Mr. L. Bartett's technical advice in designing and setting up the equipment for measuring the diffusing capacity was invaluable.Other technical help was provided by Mrs. L. Hoolwere, and Mrs. J.Pedneault who performed the blood gas analyses and Miss L. Lafontaine for preparing histological sections and Miss M. Charbonneau for preparing paper mounted whole lung sections. Miss G. E. Angus was responsible for the assessment of the internal surface area of the lung. The illustrations were done by Mr. M. Wanngeon.Very special thanks are extended to Mr. S. Vongpaisal and Mr.S. Nepszy for their assistance in so many ways to complete this thesis.Finally, thanks are due to Miss J. Lukjaniec for the many pains taken during the task of typing this thesis.(ii) ABSTRACT Varying degrees of pan1obu1ar emphysema was produced in 10 dogs by intratrachea1 injection of papain. Pu1monary function was studied before and after the deve10pment of emphysema. The production of emphysema 1ed to an increase FRC, RV and TLC of 23%, 24%, 16% respective1y. The arteria1 oxygen saturation decreased by 8% and the Pao 2 by 19 mmHg. There was no significant effect on the Paco 2 , pH and bicarbonate. Steady state diffusing capacity was reduced by 55, comp1iance increased by 63% and there was a shift in the static pressure volume curve of the 1ung upward and to the 1eft. The re1ationship between pu1monary resistance, ~, and 1ung volume was not significant1y changed. However, fo11owing excision of the 1ungs, ~ was partitioned by the retrograde catheter technique and the periphera1 resistance was abnorma11y high accounting from 33 to 84 of~. There was a decrease in the resistance of the central airways exp1aining the preservation of a norma1~. Trivial to moderate pan1obu1ar emphysema was found in the anima1s and was usua11y fair1y loca1ized in 2xtent. Mean 1inear intercept ranged from 0.124 to 0.258 (normal 0.009 -0.149). The a1veo1ar surface area at a standard 1ung volume was reduced to 33.0 -57.0 (normal 59 -71). With exception of the FRC there was no significant corre1a-tian between any of the function tests and the degree of emphysema. The data presented in this thesis represents an attempt ta crea te such a model in the dog.-2- Histological ReviewSince vesicu1ar and interstitial emphysema was first recognized and described by Laennec (66), in 1819, a number of studies on the disease have been reported. Many attempts to produce emphysema experimenta11y have been carried out on a...

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The Centrilobular Form of Hypertrophic Emphysema and its Relation to Chronic Bronchitis

Cited by 296 publications

References 10 publications

Respiratory bronchiolitis in smokers with spontaneous pneumothorax

Respiratory bronchiolitis in smokers with spontaneous pneumothorax

Relative Effects of Air Pollution on Lungs and Heart

Experimental Pulmonary Emphysema in Dogs

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