The cementum–dentin junction also contains glycosaminoglycans and collagen fibrils

Ho, Sunita P.; Sulyanto, Rosalyn; Marshall, Sally J.; Marshall, Grayson W.

doi:10.1016/j.jsb.2005.05.003

Cited by 52 publications

(47 citation statements)

References 39 publications

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“…The soft constituents are fibrous protein (collagen), and polyanionic molecules (glycosaminoglycans (GAGs)), that absorb water molecules. It is thought that the collagen-GAG interaction with water molecules contributes to the extracellular matrix swelling pressure or hydrostatic pressure which, in part can resist mechanical loads [18]. The hard constituent, mineral, (adjacent or within the collagen fibers) could provide an additional reinforcement, thus increasing the mechanical resistance of tissues.…”

Section: Discussionmentioning

confidence: 99%

The tooth attachment mechanism defined by structure, chemical composition and mechanical properties of collagen fibers in the periodontium

et al. 2007

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In this study, a comparison between structure, chemical composition and mechanical properties of collagen fibers at three regions within a human periodontium, has enabled us to define a novel tooth attachment mechanism. The three regions include 1) the enthesis region: insertion site of periodontal ligament fibers (collagen fibers) into cementum at the root surface, 2) bulk cementum and 3) the cementum dentin junction (CDJ). Structurally, continuity in collagen fibers was observed from the enthesis, through bulk cementum and CDJ. At the CDJ the collagen fibers split into individual collagen fibrils and intermingled with the extracellular matrix of mantle dentin. Under wet conditions, the collagen fibers at the three regions exhibited significant swelling suggesting a composition rich in polyanionic molecules such as glycosaminoglycans. Additionally, site-specific indentation illustrated a comparable elastic modulus between collagen fibers at the enthesis (1 -3 GPa) and the CDJ (2 -4 GPa). However, the elastic modulus of collagen fibers within bulk cementum was higher (4 -7 GPa) suggesting presence of extrafibrillar mineral.It is known that the tooth forms a fibrous joint with the alveolar bone which is termed a gomphosis. Although narrower in width than the periodontal ligament space, the hygroscopic CDJ can also be termed as a gomphosis; a fibrous joint between cementum and root dentin capable of accommodating functional loads similar to that between cementum and alveolar bone. From an engineering perspective, it is proposed that a tooth contains two fibrous joints that accommodate the masticatory cyclic loads. These joints are defined by the attachment of dissimilar materials via graded stiffness interfaces, such as; 1) alveolar bone attached to cementum with the PDL and 2) cementum to root dentin with the CDJ. Thus, through variations in concentrations of basic constituents, distinct regions with characteristic structures and graded properties allow for attachment and the load bearing characteristics of a tooth.

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Section: Discussionmentioning

confidence: 99%

The tooth attachment mechanism defined by structure, chemical composition and mechanical properties of collagen fibers in the periodontium

et al. 2007

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“…Others have shown that enamel crystals are formed at a given distance from the dentine surface (Simmer and Fincham 1995;Diekwisch et al 1995;Aoba 1996;Bodier-Houllé et al 2000) and could either reach dentine crystals by a subsequent growth (Takano et al 1996) or remain distant (Bodier-Houllé et al 2000;Dong and Warshawsky 1996). In addition, there are both a cementum-enamel junction (CEJ) (Wang et al 2006b), which is quite similar to DEJ, and a cementumdentine junction (CDJ) (Ho et al 2004(Ho et al , 2005Jang et al 2014).…”

Section: Teethmentioning

confidence: 99%

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Dorozhkin¹

2017

Morphologie

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“…37 It was reported that collagenase from C. histolyticum could attack collagen chains at several positions, thereby accelerating the degradation of collagen brils. 38 Hence, bacterial collagenase was selected to challenge the adhesivedentin interface in the present study. Our study found that onemonth collagenase storage reduced the bonding strength of the control group (an approximately 31% reduction from a mean of 37.84 to 26.18) in the absence of quercetin pretreatment (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Quercetin as a simple but versatile primer in dentin bonding

Yang

Yan

et al. 2017

RSC Adv.

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Poor bonding stability remains the "Achilles' heel" of dentin bonding, a simple and effective approach to inhibit the activities of both exogenous collagenases and endogenous MMPs, and prevention of the growth of bacterial biofilm is therefore highly demanded. In the present study, a quercetin/ethanol solution was developed as a multifunctional primer to pretreat the dentin surface during adhesive restoration. The results showed that pretreatment with quercetin/ethanol solutions (0.5 and 1.0 wt%) on the dentin surface effectively preserved the bonding strength after one-month of collagenase aging (p < 0.05). Irrespective of aging, lower nanoleakage expression and less cohesive failure in dentin were observed in the quercetin-treated groups (p < 0.05). Compared with the control group, the in situ zymography test revealed that the 0.5 and 1.0 wt% quercetin-treated dentin effectively inhibited MMP activity, while their contact angles significantly increased. Live/dead bacterial staining and the MTT assay demonstrated that the 0.5 and 1.0 wt% quercetin groups exerted significant bactericidal effects while inhibiting biofilm growth of Streptococcus mutans (p < 0.05). We believe that a quercetin/ethanol solution might serve as a simple but versatile primer to provide dentists with a promising approach to obtain desirable bonding stability and to prevent secondary caries, thereby preventing the frequent replacement of resin-based restorations.

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The cementum–dentin junction also contains glycosaminoglycans and collagen fibrils

Cited by 52 publications

References 39 publications

The tooth attachment mechanism defined by structure, chemical composition and mechanical properties of collagen fibers in the periodontium

The tooth attachment mechanism defined by structure, chemical composition and mechanical properties of collagen fibers in the periodontium

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Quercetin as a simple but versatile primer in dentin bonding

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