The cell's self-generated “electrome”: The biophysical essence of the immaterial dimension of Life?

Loof, Arnold De

doi:10.1080/19420889.2016.1197446

Cited by 63 publications

(61 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In order to present a complimentary view to existing theories, a versatile approach to the problem is presented, based on the embedding of proteins in an integral cellular context. This includes, apart from the known genome and proteome modalities, a well defined "electrome" aspect [7]. We consider the protein molecule as being influenced by the various long and short distance force fields of nature such as gravity, electromagnetism, and zero-point energy, in addition to intrinsic vibratory states of macromolecules that generate coherent excitations in the cell.…”

Section: Alternatives For Classical Approachesmentioning

confidence: 99%

“…">Alternatives for Classical ApproachesThe present study aims at creating a systematic overview of a wide spectrum of EM frequencies that may influence protein folding, in order to unravel the mechanisms by which proteins obtain their functional conformation as parts of integral vibratory networks for inter-and intra-cellular communication.In order to present a complimentary view to existing theories, a versatile approach to the problem is presented, based on the embedding of proteins in an integral cellular context. This includes, apart from the known genome and proteome modalities, a well defined "electrome" aspect [7]. We consider the protein molecule as being influenced by the various long and short distance force fields of nature such as gravity, electromagnetism, and zero-point energy, in addition to intrinsic vibratory states of macromolecules that generate coherent excitations in the cell.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Guided Folding of Life’s Proteins in Integrate Cells with Holographic Memory and GM-Biophysical Steering

Meijer¹,

Geesink²

2018

OJBIPHY

View full text Add to dashboard Cite

The current geometric and thermodynamic approaches in protein folding studies do not provide a definite solution to understanding mechanisms of folding of biological proteins. A major problem is that the protein is first synthesized as a linear molecule that subsequently must reach its native configuration in an extremely short time. Hydrophobicity-hydrophilicity models and random search mechanism cannot explain folding to the 3-D functional form in less than 1 second, as it occurs in the intact cell. We propose an integral approach, based on the embedding of proteins in the whole cellular context under the postulate: a life protein is never alone. In this concept the protein molecule is influenced by various long and short distance force fields of nature such as coherent electromagnetic waves and zero-point energy. In particular, the role of solitons is reviewed in relation to a novel GM-scale biophysical principle, revealed by us. This recent finding of a set of discrete EM frequency bands, that either promote or endanger life conditions, could be a key in further studies directed at the morphogenetic aspects of protein folding in a biological evolutionary context. In addition, an alternative hypothesis is presented in which each individual cell may store integral 3-D information holographically at the virtual border of a 4-D hypersphere that surrounds each living cell, providing a field receptive memory structure that is instrumental in guiding the folding process towards coherently oscillating protein networks that are crucial for cell survival.(hydrophobic-hydrophilic) model, is extremely complex (i.e., generally requires an enormous number of steps [2]. Levinthal concluded rightfully that a random search can only be performed in an unrealistic timeframe of billions of years [1]. Thus two major questions remain: what are the actual folding mechanisms and how can this ultra-rapid process be realized in the whole, intact, cell structure?Martinez noted that the current folding models had weak predictive ability [3]. Natural proteins consist of 100 to 500 building blocks (alpha-amino-acids), but a random search mechanism cannot provide real-time folding on the order of 1 sec. for these proteins. In the framework of a funnel-like energy landscape, the author considers a simple kinetic model of protein folding. However, this kinetic model assumes that once a domain reaches the correct state, it stays there. However, it remains unclear how the domain "knows" that it reached the correct state. After all, an intermediate state is not the minimum energy a state-the minimum is only expected for the whole structure. In the current geometric and thermodynamic approaches in protein folding mechanisms, impressive progress was made, as for instance exemplified by recent papers [4] [5], yet such bottom up approaches fail to provide a satisfactory and generally predictive solution.Munoz and Cerminara recently reviewed current generation of thermodynamic methods to map ultrafast folding landscapes, interaction networks and var...

show abstract

Section: Alternatives For Classical Approachesmentioning

confidence: 99%

mentioning

confidence: 99%

Guided Folding of Life’s Proteins in Integrate Cells with Holographic Memory and GM-Biophysical Steering

Meijer¹,

Geesink²

2018

OJBIPHY

View full text Add to dashboard Cite

show abstract

“…The particular cellular sensors are composed of flexible three dimensional structures of proteins, oligo-nucleotides and elements of the cell skeleton, that mutually communicate through discrete wave resonances and are sensitive to fluxes of photons, phonons, excitons and related quasi particles such as polarons (solitons) and polaritons. This biosensing apparatus, situated in an apparently electromagnetic cell, was tentatively called electrome (de Loof, 2016), and is under the continuous influence of natural occurring internal as well as external electromagnetic fields (Meijer and Geesink, 2017).…”

Section: Electromagnetic Aspects Of Dynamic Models Of Consciousnessmentioning

confidence: 99%

Consciousness in the Universe is Scale Invariant and Implies an Event Horizon of the Human Brain

Meijer¹,

Geesink²

2017

Neuroquantology

View full text Add to dashboard Cite

Our brain is not a "stand alone" information processing organ: it acts as a central part of our integral nervous system with recurrent information exchange with the entire organism and the cosmos. In this study, the brain is conceived to be embedded in a holographic structured field that interacts with resonant sensitive structures in the various cell types in our body. In order to explain earlier reported ultra-rapid brain responses and effective operation of the meta-stable neural system, a field-receptive mental workspace is proposed to be communicating with the brain. Our integral nervous system is seen as a dedicated neural transmission and multi-cavity network that, in a non-dual manner, interacts with the proposed supervening meta-cognitive domain. Among others, it is integrating discrete patterns of eigen-frequencies of photonic/solitonic waves, thereby continuously updating a time-symmetric global memory space of the individual. Its toroidal organization allows the coupling of gravitational, dark energy, zero-point energy field (ZPE) as well as earth magnetic fields energies and transmits wave information into brain tissue, that thereby is instrumental in high speed conscious and sub-conscious information processing. We propose that the supposed field-receptive workspace, in a mutual interaction with the whole nervous system, generates self-consciousness and is conceived as operating from a 4 th spatial dimension (hyper-sphere). Its functional structure is adequately defined by the geometry of the torus, that is envisioned as a basic unit (operator) of space-time. The latter is instrumental in collecting the pattern of discrete soliton frequencies that provided an algorithm for coherent life processes, as earlier identified by us. It is postulated that consciousness in the entire universe arises through, scale invariant, nested toroidal coupling of various energy fields, that may include quantum error correction. In the brain of the human species, this takes the form of the proposed holographic workspace, that collects active information in a "brain event horizon", representing an internal and fully integral model of the self. This brain-supervening workspace is equipped to convert integrated coherent wave energies into attractor type/standing waves that guide the related cortical template to a higher coordination of reflection and action as well as network synchronicity, as required for conscious states. In relation to its scale-invariant global character, we find support for a universal information matrix, that was extensively described earlier, as a supposed implicate order as well as in a spectrum of space-time theories in current physics. The presence of a field-receptive resonant workspace, associated with, but not reducible to, our brain, may provide an interpretation framework for widely reported, but poorly understood transpersonal conscious states and algorithmic origin of life. It also points out the deep connection of mankind with the cosmos and our major responsibility for the future of our ...

show abstract

“…Physiology can thereby be viewed in an integrated manner that extends far beyond a description of metabolic intermediates, yielding to a finite set of initiating First Principles upon which any cellular component, including the crucial conformation of the cytoskeleton, depends on continuous reaction to contemporary stresses built on lifetimes of experience phylogenetically. The cytoskeleton has long been viewed purely as a cellular architectural element (Hardin, Bertoni and Kleinsmith, 2015), but in fact additionally aids and abets the collection of epigenetic marks (Trerotola et al, 2015), just as every other aspect of the cell participates (Torday and Rehan, 2017), including its prime importance for the functioning of the cognitive memory system according to De Loof (2016). These proximate markers of environmental stress must be purposed towards the long-term preservation of homeostatic status according to the ultimate primordial rules embodied within the First Principles of Physiology.…”

Section: Physical Phenomena and Cellular Requirementsmentioning

confidence: 99%

The resolution of ambiguity as the basis for life: A cellular bridge between Western reductionism and Eastern holism

Torday

Miller

2017

Progress in Biophysics and Molecular Biology

View full text Add to dashboard Cite

Boundary conditions enable cellular life through negentropy, chemiosmosis, and homeostasis as identifiable First Principles of Physiology. Self-referential awareness of status arises from this organized state to sustain homeostatic imperatives. Preferred homeostatic status is dependent upon the appraisal of information and its communication. However, among living entities, sources of information and their dissemination are always imprecise. Consequently, living systems exist within an innate state of ambiguity. It is presented that cellular life and evolutionary development are a self-organizing cellular response to uncertainty in iterative conformity with its basal initiating parameters. Viewing the life circumstance in this manner permits a reasoned unification between Western rational reductionism and Eastern holism.

show abstract

The cell's self-generated “electrome”: The biophysical essence of the immaterial dimension of Life?

Cited by 63 publications

References 42 publications

Guided Folding of Life’s Proteins in Integrate Cells with Holographic Memory and GM-Biophysical Steering

Guided Folding of Life’s Proteins in Integrate Cells with Holographic Memory and GM-Biophysical Steering

Consciousness in the Universe is Scale Invariant and Implies an Event Horizon of the Human Brain

The resolution of ambiguity as the basis for life: A cellular bridge between Western reductionism and Eastern holism

Contact Info

Product

Resources

About