The resolution of ambiguity as the basis for life: A cellular bridge between Western reductionism and Eastern holism

Abstract

Boundary conditions enable cellular life through negentropy, chemiosmosis, and homeostasis as identifiable First Principles of Physiology. Self-referential awareness of status arises from this organized state to sustain homeostatic imperatives. Preferred homeostatic status is dependent upon the appraisal of information and its communication. However, among living entities, sources of information and their dissemination are always imprecise. Consequently, living systems exist within an innate state of ambiguity. It is presented that cellular life and evolutionary development are a self-organizing cellular response to uncertainty in iterative conformity with its basal initiating parameters. Viewing the life circumstance in this manner permits a reasoned unification between Western rational reductionism and Eastern holism.

Evolution, the ‘Mechanism’ of Big History: The Grande Synthesis

“…In the case of Big History, this perspective confers a deep understanding of who and what we are conceptually. On the other hand, understanding that we have evolved biologically as an 'ambiguity' (Torday and Miller, 2017), our function being to resolve the residual dualities of the S/BB (Torday, 2018a). Seen in this light, evolution offers the organic, epistemologic context for Big History.…”

The Awareness of the Fascial System

“…Cellular morphology affects the extracellular matrix shape, influencing how the mechanometabolic resulting message will be transported: slow, fast or conditioning its direction [ 44 ]. Probably this kind of "mirror" behaviour would allow the cell to better respond to stress solicitation, improving its adaptation [ 45 ]. The cytoskeleton plays an important role for cell conformational memory, thanks to a metabolic regulator as the target of rapamycin (TOR), which acts on polymerization of actin, determining its cytoskeletal conformation [ 45 ].…”

“…Probably this kind of "mirror" behaviour would allow the cell to better respond to stress solicitation, improving its adaptation [ 45 ]. The cytoskeleton plays an important role for cell conformational memory, thanks to a metabolic regulator as the target of rapamycin (TOR), which acts on polymerization of actin, determining its cytoskeletal conformation [ 45 ]. A fundamental role played by the actomyosin complex is collecting information outside the cell and at the same time reinforcing the cell.…”

Biological Organization Principles: Biogenesis, Cognition and Evolution of Living Systems

“…Modern Biology, although it is a sophisticated experimental science, still suffers from uncertain theoretical underpinnings 2 . Thus current biological principles, although supported by a wide spectrum of ideas ranging from physical-chemistry to evolutionary theory, is in search of its own formal logic [8,9,10,11].…”