The CD7− subset of CD4+ memory T cells is prone to accelerated apoptosis that is prevented by interleukin-15 (IL-15)

Rappl, Gunter; Abken, Hinrich; Hasselmann, Dirk O.; Tilgen, Wolfgang; Ugurel, Selma; Reinhold, Uwe

doi:10.1038/sj.cdd.4400825

Cited by 11 publications

(8 citation statements)

References 51 publications

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“…Our data indicate that oxidative stress-mediated apoptosis induced by H 2 O 2 was more prominent in T cells cultured with IL-2 than in those cultured with IL-15 ( Figure 1A). These results are similar to those shown by earlier studies highlighting anti-apoptotic characteristic of IL-15 [25-27]. However, we reasoned that for an oxidative agent such as H 2 O 2 to induce cell death differentially, differences must exist in reduced or oxidized surface molecules/proteins which could correlate to the cytokines used for pretreatment and hence the difference in susceptibility to H 2 O 2 -mediated apoptosis.…”

Section: Resultssupporting

confidence: 90%

T cells expanded in presence of IL-15 exhibit increased antioxidant capacity and innate effector molecules

et al. 2011

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Persistence of effector cytotoxic T lymphocytes (CTLs) during an immunological response is critical for successfully controlling a viral infection or tumor growth. Various cytokines are known to play an important part in regulating the immune response. The IL-2 family of cytokines that includes IL-2 and IL-15 are known to function as growth and survival factors for antigen-experienced T cells. IL-2 and IL-15 possess similar properties, including the ability to induce T cell proliferation. Whereas long term IL-2 exposure has been shown to promote apoptosis and limit CD8+ memory T cell survival and proliferation, it is widely believed that IL-15 can inhibit apoptosis and helps maintain a memory CD8+ T-cell population. However, mechanisms for superior outcomes for IL-15 as compared to IL-2 are still under investigation. Our data shows that human T cells cultured in the presence of IL-15 exhibit increased expression of anti-oxidant molecules Glutathione reductase (GSR), Thioredoxin reductase 1 (TXNDR1), Peroxiredoxin (PRDX), Superoxide dismutase (SOD). An increased expression of cell-surface thiols, intracellular glutathione, and thioredoxins was also noted in IL-15 cultured T cells. Additionally, IL-15 cultured T cells also showed an increase in cytolytic effector molecules. Apart from increased level of Granzyme A and Granzyme B, IL-15 cultured T cells exhibit increased accumulation of reactive oxygen (ROS) and reactive nitrogen (RNS) species as compared to IL-2 cultured T cells. Overall, this study suggests that T cells cultured in IL-15 show increase persistence not only due to increased anti-apoptotic proteins but also due to increased anti-oxidant levels, which is further complimented by increased cytolytic effector functions.

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Section: Resultssupporting

confidence: 90%

T cells expanded in presence of IL-15 exhibit increased antioxidant capacity and innate effector molecules

et al. 2011

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“…6 However, our in vivo studies identified a lack of FOXP3+ cells in SS and therefore excluded the use of FOXP3 as a possible tumour cell marker in SS. 7 Other groups have identified Sézary cells by loss of CD7 8,9 or CD26. [10][11][12][13] However, loss of CD26 is seen in only about half of the patients.…”

Section: Discussionmentioning

confidence: 99%

The diagnosis of Sézary syndrome on peripheral blood by flow cytometry requires the use of multiple markers

Klemke

Brade

Weckesser

et al. 2008

British Journal of Dermatology

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“…Cells of the population CD7 ) from the peripheral blood of all Se´zary syndrome patients are resistant to galectin-1-induced apoptosis. Thus, resistance of CD7 ) T cells to galectin-1-induced apoptosis may contribute to the accumulation of CD7 ) Se´zary T cells during progression of the disease [58,82].…”

Section: Cd7mentioning

confidence: 97%

Galectin-1 receptors in different cell types

et al. 2005

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Galectins are a family of animal lectins defined by two properties: shared amino acid sequences in their carbohydrate-recognizing domain, and beta-galactoside affinity. A wide variety of biological phenomena are related to galectins, i.e., development, differentiation, morphogenesis, tumor metastasis, apoptosis, RNA splicing, and immunoregulatory function. In this review, we will focus on galectin-1 receptors, and some of the mechanisms by which this lectin affects different cell types. Several galectin-1 receptors are discussed such as CD45, CD7, CD43, CD2, CD3, CD4, CD107, CEA, actin, extracellular matrix proteins such as laminin and fibronectin, glycosaminoglycans, integrins, a beta-lactosamine glycolipid, GM1 ganglioside, polypeptide HBGp82, glycoprotein 90 K/MAC-2BP, CA125 cancer antigen, and pre-B cell receptor.

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The CD7− subset of CD4+ memory T cells is prone to accelerated apoptosis that is prevented by interleukin-15 (IL-15)

Abstract: The CD7

Cited by 11 publications

References 51 publications

T cells expanded in presence of IL-15 exhibit increased antioxidant capacity and innate effector molecules

T cells expanded in presence of IL-15 exhibit increased antioxidant capacity and innate effector molecules

The diagnosis of Sézary syndrome on peripheral blood by flow cytometry requires the use of multiple markers

Galectin-1 receptors in different cell types

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