The CC chemokine ligand 2 (CCL2) polymorphism −2518A/G is associated with gout in the Chinese Han male population

Abstract

Gout is usually characterized by uric acid-induced recurrent attacks of acute inflammatory arthritis. CC chemokine ligand 2 (CCL2), a chemokine involved in the recruitment and migration of monocytes/macrophages, has previously been shown to be increased in the plasma of gout patients. In this study, we examined whether the CCL2 -2518A/G (rs1024611) single nucleotide polymorphism (SNP) affects susceptibility to gout in a Chinese Han male population. Genomic DNA from gout patients (n = 1,109) and ethnically matched gout-free controls (n = 1,034) was genotyped for the CCL2 -2518A/G SNP using polymerase chain reaction-restriction fragment length polymorphism. The Chi-square test was performed to investigate the association of genotypic and allelic frequencies between cases and controls, and the -2518G allele was shown to be associated with a significantly increased risk of gout development [P = 0.007, odds ratio 1.182, 95% confidence interval 1.047-1.335]. The GG genotypic distribution was also significantly different between cases and controls (adjusted P = 0.021). However, genotypic distributions and allelic frequencies did not indicate significant associations (P = 0.150 and P = 0.050, respectively) between tophi and non-tophi patients. Our findings support a key role for the CCL2 SNP -2518A/G in association with gout susceptibility in the Chinese Han male population. However, additional studies in other populations should be carried out to confirm this finding.

Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout

“…Monocyte Chemoattractant Protein 1 (MCP-1), also known as CCL2 (CC chemokine ligand 2) is an important member of the C-C (Cysteine-Cysteine) chemokine family and plays a crucial role in the recruitment of monocytes, memory T cells, and basophils into inflamed tissues. A functional SNP in CCL2 gene promoter region, rs1024611 (-2518A/G) was associated with gout in a study of a Chinese male cohort [ 131 ]. This SNP was reported to impact CCL2 expression in patients with Systemic Sclerosis (SSc) [ 132 ].…”