The catalytic thermo-oxidative decomposition of glimepiride using the isoconversional method

Abstract

Applying the isoconversional method to data obtained from thermogravimetric analysis (TGA) can provide vital kinetic information. In this work, the thermal decomposition and oxidation of the antidiabetic drug glimepiride is analyzed in the presence of N2 and O2. The study was done with and without metal oxide catalysts to explore their potential application in solid wastewater upgrading. The analysis was conducted using thermogravimetric analysis. The isoconversional methods of Kissinger–Akahira–Sunose and Friedman were used to estimate the effective activation energies as a function of the extent of conversion (α). Density functional calculations were used to estimate the bond dissociation energies in glimepiride. The Ea values obtained from the Friedman method and the DFT calculations indicate an initial S–N bond breaking in glimepiride. The pre-exponential factor (A) and the kinetic triplet (ΔH‡, ΔS‡, and ΔG‡) are also discussed. When glimepiride oxidation was studied in the presence of the metal oxides, the catalyst activity was found to follow the order $${\text{VO}}_{{2}} > {\text{ CuO }} > {\text{ MnO}}_{{2}} > {\text{ Al}}_{{2}} {\text{O}}_{{3}} > {\text{ TiO}}_{{2}}$$ VO 2 > CuO > MnO 2 > Al 2 O 3 > TiO 2 .

The mechanism of fluorescence quenching of naphthalimide A/C leak detector by copper (II)

“…The QTAIM calculations were done using the ADF engine in Amsterdam Modeling Suite (AMS) 2022 [33][34][35]. Further details on the calculations used in this work were reported in previous publications [36][37][38][39][40][41].…”

Efficient Multi‐walled Carbon Nanotubes/Iron Oxide Nanocomposite for the Removal of the Drug Ketoprofen for Wastewater Treatment Applications

“…Traditionally, several wastewater techniques such as coagulation and flocculation, centrifugation, advanced oxidation, aerobic and anaerobic treatments are employed. But because PPCP cannot be eliminated using conventional approaches, new technologies are required to satisfy the ZLD and MLD standards [3,14–16] …”