The Catalase –262C/T Promoter Polymorphism and Diabetic Complications in Caucasians with Type 2 Diabetes

Santos, Kátia Gonçalves dos; Canani, Luís Henrique Santos; Gross, Jorge Luiz; Tschiedel, Balduíno; Souto, Kátia Elisabete Pires; Roisenberg, Israel

doi:10.1155/2006/983408

Cited by 41 publications

(27 citation statements)

References 19 publications

(36 reference statements)

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“…Moreover other study from India was reported that GPx1 'C' allele indicated a 1.362 times higher risk of T2DM. Additionally other study from china was reported that there was no statistically significant association between the GPX1-198C/T gene polymorphisms and the risk of DR [18,20,[21][22][23][24][25][26][27][28][29][30]. Serum anti-oxidant activity (GPx) was significantly lower among DR (P=0.001), compared with DNR individuals.…”

Section: N=60 N=70mentioning

confidence: 99%

“…Free radicals formation in diabetes mellitus and increase over time may play a role in the development of diabetic retinopathy, which is an important complication of the disease [26]. Oxidative stress can influence the expression of multiple genes, including signalling molecules; over expression of these genes may cause mitochondrial dysfunction and peroxidization of the lipid and protein structure, which induce a variety of cellular dysfunctions leading to retinopathy [23]. Elvated oxidized lipids, DNA and protein in diabetics, represent a diminished capacity to decrease toxic reactive oxygen [26].…”

Section: N=60 N=70mentioning

confidence: 99%

“…Finally, poor glycemic control increases the risk for diabetic retinopathy. Moreover, a limited period of poor glycemic control can have a prolonged effect on the incidence of diabetic retinopathy ("metabolic memory") as demonstrated by the Epidemiology of Diabetes Interventions and Complications (EDIC) cohort follow-up [23]. The association between serum lipid levels and DR has been investigated in many studies, several studies have shown that the serum cholesterol level was associated with increased risk and severity of retinal hard exudates [18,26].…”

Section: N=60 N=70mentioning

confidence: 99%

“…The association between serum lipid levels and DR has been investigated in many studies, several studies have shown that the serum cholesterol level was associated with increased risk and severity of retinal hard exudates [18,26]. Treatment of hard exudates by atorvastatin has a significant associated with reduction in the severity and decrease the risk of the lipid in clinically significant macular edema [18,23]. The present study observed that, there was significant association between hyperlipidemia and DR [18].…”

Section: N=60 N=70mentioning

confidence: 99%

“…This agrees with result obtained from Wisconsin Epidemiologic Study. The results should be compared with those of the Wisconsin Epidemiologic Study of diabetic retinopathy and its relation to various risk factors [18,23] The Wisconsin study reported that the glycated hemoglobin is associated with increased risk of incidence of PDR. Also, the result of present study show that there was significant different in main concentration of serum GPX antioxidant enzymes of DR in compared with DNR with (p=0.001).…”

Section: N=60 N=70mentioning

confidence: 99%

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Association 0f Gpx-198C/T Gene Polymorphism (rs1050450-198C/T) in Sudanese with Diabetic Retinopathy

Nmn¹,

Ea²,

Am³

et al. 2017

J Blood Lymph

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Background: Diabetic retinopathy is the common micro-vascular complication of diabetes mellitus. It is the main cause of blindness among young adults worldwide. Poor glycemic control in addition to longer diabetic duration is the main risk factors for diabetic retinopathy. Many genes have been postulated as candidates for diabetic retinopathy. Little is known about anti-oxidative enzyme gene polymorphism and its association with diabetic retinopathy, mainly for catalase enzyme and manganese superoxide dismutase and glutathone genes. The study aims to assess the role of glutathone GPX-198C/T (rs1050450) gene polymorphism in diabetic retinopathy Sudanese patients and its relation with GPX level. In addition to determine the association of FBS, HbA1c and lipid in the pathogenesis of diabetic retinopathy. Methodology:The number of subjects involved were 130 which were classified into (n 60) clinically diagnosed as diabetic retinopathy and (n 70) diabetes mellitus without retinopathy as control group, age ranged from 22 to 80 years old, from Makkah Eye Complex. DNA was extracted and PCR product for GPX, gene segment were digested by Aba1 enzymes, moreover gene polymorphisms were determined. Serum GPX, activity and FBS, TG, CHOL and HbA1c level were analyzed using Cobas Int 400 using absorption photometer and immunoassay methods respectively. Results:The results revealed that, retinopathy is common in female than male by approximately 2 fold =1.9:1. Type II is more common in our population that type 1. The majority of the patients had type II diabetes (128, 98.5%) and only 2(1.5%) patients were type I diabetes mellitus. The activity of GPX, was significantly higher in DNR when compared with DR (p=0.003). Mean HbA1c and FBG concentration were significantly higher among DR than DNR p=0.001 and p=0.001 respectively. In contrast, mean serum CHOL and TG level revealed insignificant differences when compared DR with DNR. The genotyping for GPX-198C/T showed that, the frequency of CC was observed in 33(47%) in control higher than cases 13(22%), theses Associations for CCs, GPX-198C/T SNP rs1050450, decreased risk after correction for multiple testing (OR=0.310, 95% CI=0.176-0.486, p=0.001), While TT genotype was detected in 25(42%) cases and only 14(20%) in controls, these Associations for SNPs, TTs, GPX-198C/T SNP rs1050450, increased risk after correction for multiple testing (OR=2.4, 95% CI=1.10-5.90, p=0.004). The frequency of the allele C protective allele was found to be 48% among cases group while allele T-risky allele was higher among cases group 72%, OR=0.357 (0.216-0.433), p=0.001. Conclusion:The study concludes that there is a significant association between GPX-198C/T (rs1050450) gene polymorphism and the occurrence of diabetic retinopathy in Sudanese population. There is a significant decrease in GPX levels and glycemic control in patients with the mutant allele T. complications as retinopathy [6,7]. ROS reactive oxygen species are most common processes to develop vascular complications. Journal of Blood...

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Section: N=60 N=70mentioning

confidence: 99%

Section: N=60 N=70mentioning

confidence: 99%

Section: N=60 N=70mentioning

confidence: 99%

Section: N=60 N=70mentioning

confidence: 99%

Section: N=60 N=70mentioning

confidence: 99%

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Association 0f Gpx-198C/T Gene Polymorphism (rs1050450-198C/T) in Sudanese with Diabetic Retinopathy

Nmn¹,

Ea²,

Am³

et al. 2017

J Blood Lymph

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Association of a single nucleotide polymorphism in SOD2 with susceptibility for the development of diabetic nephropathy in patients with type 2 diabetes: A Saudi population study

Sultan,

Alharbi,

Alrayes

et al. 2023

Endocrino Diabet & Metabol

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IntroductionOne of the complications of diabetes mellitus (DM) is diabetic nephropathy (DN), which plays a significant role in the progression of end‐stage renal disease. Oxidative stress is implicated in DN pathogenesis, and genetic variations in antioxidant enzymes such as superoxide dismutase 2 (SOD2) and catalase (CAT) may contribute to the susceptibility. This study aimed to investigate the potential association between single nucleotide polymorphisms (SNPs) in antioxidant enzymes, specifically SOD2 rs4880 and CAT rs769217, and the risk of T2D and susceptibility to DN within the Saudi population.MethodsThis case–control study included 150 participants, comprising 50 patients with T2D without DN (group 1), 50 patients with T2D with DN (group 2), and 50 healthy participants (group 3). The samples were genotyped using real‐time PCR for SOD2 rs4880 and CAT rs769217 SNPs. Sanger sequencing was used for validation. Statistical analyses were performed to explore associations between these SNPs and T2D with or without DN.ResultsNo significant difference was observed in CAT rs769217 expression between the groups. However, a significant difference was observed in SOD2 rs4880 expression between the healthy controls and patients with T2D with DN (p = .028). Furthermore, SOD2 rs4880 was associated with approximately threefold increased risk of DN in patients with T2D compared to that in healthy participants (odds ratio [OR] = 2.99 [1.31–6.83]). Validation through Sanger sequencing further confirmed these findings.ConclusionsThe findings of this study provide evidence that SOD2 rs4880 SNP may contribute to inadequate defence by the antioxidant enzyme, SOD2, against DM‐induced oxidative stress and thus cause DN in Saudi patients with T2D. Therefore, SOD2 rs4880 may serve as a predictive marker to prevent the development and progression of DN in patients with T2D.

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No evidence for a major effect of three common polymorphisms of the GPx1, MnSOD, and CAT genes on PCOS susceptibility

Salahshoor

Sohrabi

Jalili

et al. 2018

J of Cellular Biochemistry

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The Catalase –262C/T Promoter Polymorphism and Diabetic Complications in Caucasians with Type 2 Diabetes

Cited by 41 publications

References 19 publications

Association 0f Gpx-198C/T Gene Polymorphism (rs1050450-198C/T) in Sudanese with Diabetic Retinopathy

Association 0f Gpx-198C/T Gene Polymorphism (rs1050450-198C/T) in Sudanese with Diabetic Retinopathy

Association of a single nucleotide polymorphism in SOD2 with susceptibility for the development of diabetic nephropathy in patients with type 2 diabetes: A Saudi population study

No evidence for a major effect of three common polymorphisms of the GPx1, MnSOD, and CAT genes on PCOS susceptibility

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