The CAT (COPD Assessment Test) questionnaire as a predictor of the evolution of severe COPD exacerbations

García-Sidro, Patricia; Naval, Elsa; Rivera, Carlos Martínez; Bonnin-Vilaplana, Marc; Rivero, Juan Luis García; Herrejón, Alberto; Molina, Rosa Malo de; Marcos, Pedro J.; Mayoralas-Alises, Sagrario; Ros, José Antonio; Valle, Manuel; Esquinas, Cristina; Barrecheguren, Miriam; Miravitlles, Marc

doi:10.1016/j.rmed.2015.10.011

Cited by 40 publications

(25 citation statements)

References 35 publications

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“…The suggested change of 2 units in the CAT score as a threshold of stability was considered based on the identification of the minimum clinically important difference [12]; however, Pothirat et al [25] suggested a change of 4 units as the optimum cut off point score for the detection of acute deterioration in health status with a sensitivity, specificity and accuracy of 76.8%, 83.6% and 82.4%, respectively. Similarly, a change of less than 4 units in the CAT score from admission to discharge was significantly and independently associated with increased risk of clinical failure in the three months following discharge of exacerbated COPD patients [26]. Previous work in over 3700 patients has suggested that for every 10 point worsening of CAT score there is a 28% greater risk of 2 or more exacerbations in the following year [27].…”

Section: Discussionmentioning

confidence: 97%

Evaluation of criteria for clinical control in a prospective, international, multicenter study of patients with COPD

Miravitlles

Śliwiński²,

Rhee

et al. 2018

Respiratory Medicine

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Section: Discussionmentioning

confidence: 97%

Evaluation of criteria for clinical control in a prospective, international, multicenter study of patients with COPD

Miravitlles

Śliwiński²,

Rhee

et al. 2018

Respiratory Medicine

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“…CAT impacts a patient's QOL [38], is responsive to treatment [39], and provides relevant prognostic information [40]; therefore, its use is advocated for assessing PR during AECOPD. In our study, after PR, there were significant improvements in the QOL at 4 and 12 weeks, and most patients improved above the MCID in CAT, although there were no significant differences in betweengroup comparisons.…”

Section: Discussionmentioning

confidence: 99%

Effect of high-flow nasal therapy during early pulmonary rehabilitation in patients with severe AECOPD: a randomized controlled study

et al. 2020

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Background: Chronic obstructive pulmonary disease (COPD) is airway inflammation characterized and low daily physical activity. Most pulmonary rehabilitation (PR) programs are often provided to stable patients, but fewer training programs are specific for hospitalized patients with acute exacerbation (AE). Patients with AECOPD experience increased dyspnea sensations and systemic inflammation during exercise training. High-flow nasal therapy (HFNT) reduces the minute volume, lowers the respiratory rate, and decreases the work of breathing. However, it is not clear whether HFNT is efficient during exercise training. In this study, we investigated the effects of HFNT during exercise training in an early PR program among hospitalized patients with severe AECOPD. Methods: We enrolled COPD patients hospitalized due to AE. They were randomized into two groups according to their status into HFNT PR and non-HFNT PR groups. This study collected basic data, and also assessed a pulmonary function test, 6-min walking test, blood inflammatory biomarkers, and arterial gas analysis at the baseline, and at 4 and 12 weeks of the intervention. Data were analyzed using SPSS statistical software.Result: We recruited 44 AECOPD patients who completed the 12-week PR program. The HFNT PR program produced significant improvements in exercise tolerance as assessed by the 6-min walking distance (6MWD), reduced dyspnea sensations in the modified Medical Research Council (mMRC), and decreased systemic inflammation as evidenced by the a lower C-reactive protein (CRP) level. A reduction in the length of hospitalization was achieved with PR in the 1-year follow-up in the two groups. The HFNT PR group showed better trends of reduced air trapping in the delta inspiration capacity (IC) and an increased quality of life according to the COPD assessment test (CAT) than did the non-HFNT PR group.Conclusions: HFNT during exercise training in early PR increases exercise tolerance and reduces systemic inflammation in hospitalized patients with severe AECOPD.

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“…Standard of care for patients with COPD should include measures of symptom burden, such as the CAT, to evaluate patient outcomes [34]. Physicians should consider the use of instruments such as the CAT on a continuous basis as it has been shown to be responsive to recovery from an exacerbation [32], and to predict treatment failure [35]. It is important, however, for physicians to be aware of factors that may influence the CAT score both at diagnosis and on a continual basis [36].…”

Section: Discussionmentioning

confidence: 99%

Predictors of Symptom Burden in Patients with COPD on LAMA Monotherapy: Multivariable Analysis of a Claims-Linked Survey Study

Hahn¹,

Stanford²,

Hunter

et al. 2019

Pulm Ther

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Introduction: Many patients with chronic obstructive pulmonary disease (COPD) prescribed long-acting muscarinic antagonist (LAMA) monotherapy remain symptomatic. This multivariable analysis of a previously reported claims-linked, cross-sectional survey assessed symptom burden measured by the COPD assessment test (CAT) in patients treated with LAMA monotherapy. Methods: Eligible patients aged C 40 years with COPD (C 2 International Classification of Diseases-10th Revision-Clinical Modification [ICD-Enhanced Digital Features To view enhanced digital features for this article go to https://doi.org/10.6084/ m9.figshare.8948918.

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The CAT (COPD Assessment Test) questionnaire as a predictor of the evolution of severe COPD exacerbations

Abstract: A change of ≤4 points in the CAT score at discharge compared to that obtained at admission due to a severe exacerbation of COPD, helps to predict therapeutic failure such as a new exacerbation, readmission or death in the subsequent three months.

Cited by 40 publications

References 35 publications

Evaluation of criteria for clinical control in a prospective, international, multicenter study of patients with COPD

Evaluation of criteria for clinical control in a prospective, international, multicenter study of patients with COPD

Effect of high-flow nasal therapy during early pulmonary rehabilitation in patients with severe AECOPD: a randomized controlled study

Predictors of Symptom Burden in Patients with COPD on LAMA Monotherapy: Multivariable Analysis of a Claims-Linked Survey Study

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