A number of high profile crises and disasters have driven the EU to increase cooperation among its member states in the area of civil protection and to enhance its capacity to conduct civil protection operations in Europe and around the world. However, in the light of recent transboundary crises in the EU, manifested by the refugee crisis, terrorist attacks, and natural disasters, it is far from clear how effective such cooperative EU arrangements can be due to differences in the way national civil protection has been organized and due to the question of whether sufficient trust exists within and between the involved organizations. In this article, drawing from a unique study of civil protection agencies in 17 EU member states, and utilizing theories on crisis management, public administration and trust, we shed light on the factors that promote national and EU-level effectiveness in civil protection and crisis management.