The carotid body after oxygen deficiency

Blümcke, S.; Rode, J.; Niedorf, H. R.

doi:10.1007/bf00331477

Cited by 61 publications

(15 citation statements)

References 26 publications

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“…The dense-cored vesicles of type-I cells in adults are usually scattered evenly throughout the cytoplasm (LEVER et al, 1959), whereas in the fetuses studied, they were aligned in a single layer along the cell membrane. It has been shown that the number of dense-cored vesicles decreases and that they become aggregated close to the cell membrane after exposure to hypoxia (HELLSTROM, 1977, BLUMCKE et al, 1967. Since mammalian fetuses develop in hypoxic conditions in the uterus, our findings are consistent with those of hypoxic changes in the adult carotid body.…”

Section: Newbornssupporting

confidence: 87%

Ultrastructural study on cell differentiation of the rabbit carotid body.

Kariya

Nakajima

Ozawa

1990

Archives of Histology and Cytology

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Section: Newbornssupporting

confidence: 87%

Ultrastructural study on cell differentiation of the rabbit carotid body.

Kariya

Nakajima

Ozawa

1990

Archives of Histology and Cytology

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“…Therefore, it is probable that the only amine in the type I cells is dopamine because the other amines, which are found in homogenates of carotid bodies might originate lasting (minutes) hypoxia on the number and the density of the dense core vesicles in the type I cells has been examined electron microscopically. Blimcke, Rode & Niedorf (1967) found a decrease in the number of dense core vesicles following a short exposure of rats to low oxygen tensions, but the mitochondria were swollen and the nuclei showed signs of degeneration which suggests that they were observing pathological changes, and Chen, Yates & Duncan (1969) did not find any change in the number or density of dense core vesicles in hamsters exposed to hypoxia. Al-Lami & Murray (1968), however, found in cats that the number and density of the dense core vesicles was increased by hypoxia lasting for 45 minutes.…”

Section: Discussionmentioning

confidence: 96%

The ultrastructure of the carotid body in chronically hypoxic rabbits

Møller¹,

Møllgård²,

Sørensen³

1974

The Journal of Physiology

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SUMMARY1. The ultrastructure of the carotid body in the rabbit has been examined by electron microscopy.2. A comparison was made between the ultrastructure of the carotid bodies in sea level rabbits, in rabbits which had been exposed to hypoxia equivalent to an altitude of 6000 m for 7 days and in rabbits which always had lived at an altitude of 4000-4300 m.3. We could not detect any difference in the ultrastructure between the two groups of hypoxic rabbits.4. When the hypoxic rabbits were compared with sea level rabbits there was a marked increase in the number of dense cored vesicles and mitochondria in the type I cells in the hypoxic rabbits. The Golgi region also appeared to be enlarged in the type I cells in the hypoxic rabbits.5. The finding suggests that in the rabbit the production of amines, probably dopamine, within the type I cells is increased during prolonged hypoxia which might explain the lowered ventilatory response to hypoxia observed in human high altitude residents.6. If the carotid bodies are organs of internal secretion the finding is compatible with an increased production of a hormone produced within the type I cells.

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“…It has thus become evident that the chief or glomus cells of the carotid body, without a single exception, contain catecholamines (RAHN, 1961;NIEMI and OJARA, 1964;BLUMCKE, RODE and NIEDORF, 1967;DEARNALEY, FILLENZ and WOODS 1968; UEHARA in press). Nor has an exception been found to the generalization that the chief cells of the carotid body contain more or less numerous specific dense granules first described in 1957 by LEVER and BOYD (LEVER, LEWIS and BOYD, 1959;BISCOE and STEHBENS, 1966;HESS, 1968;KOBAYASHI, 1968).…”

Section: Discussionmentioning

confidence: 99%