The cardiovascular effects of dexmedetomidine given by continuous infusion during isoflurane anesthesia in dogs

Hemodynamic effects of dexmedetomidine in isoflurane-anesthetized cats

“…Therefore, it appears that the use of dexmedetomidine as an anesthetic adjunct in cats will worsen inhalant-induced cardiovascular depression, despite the decrease in anesthetic requirements. This is in disagreement with findings in dogs, in which an intravenous loading dose of 0.5 lg kg )1 followed by a constant rate intravenous infusion of 0.5 lg kg )1 hour )1 produced close to a 20% decrease in the MAC of isoflurane, with minimal cardiopulmonary effects (Pascoe 2005).…”

The hemodynamic effects of medetomidine continuous rate infusions in the dog

“…Bradycardia was demonstrated in all treatments as was expected with the administration of an alpha-2 agonist (Bloor et al 1992;Flacke et al 1993;Pypendop & Verstegen 1998;Ko et al 2000;Kuusela et al 2000;Kuo & Keegan 2004;Grimm et al 2005;Pascoe 2005;Pascoe et al 2006). Medetomidine increases systemic vascular resistance, as also demonstrated in the study, and this was thought to lead to an autonomic reflex induced bradycardia (Flacke et al 1990).…”

“…These results are supported in other studies of medetomidine bolus dosing (Bloor et al 1992;Flacke et al 1993;Pypendop & Verstegen 1998) and another study evaluating dexmedetomidine CRIs in the dog (Pascoe 2005). In addition, Grimm et al (2005) evaluated the hemodynamic effects of medetomidine given alone as a CRI at 1.5 lg kg )1 hour )1 as well as in combination with a fentanyl bolus and demonstrated decreased HR and CI and increased left atrial pressure in dogs receiving the medetomidine CRI.…”

Cardiovascular, respiratory, electrolyte and acid–base balance during continuous dexmedetomidine infusion in anesthetized dogs

“…Low dose dexmedetomidine infusions in the range of 0.1–3 μg kg −1 hour −1 have been previously investigated and reported on in the literature (Pascoe ; Braz et al. ; Lin et al.…”