The cardioprotective effect of isosteviol on rats with heart ischemia-reperfusion injury

Gene and protein expression changes in response to normoxic perfusion in mouse hearts

“…Karaca studied the expression alteration of lactate dehydrogenase gene, induced by ischemia-reperfusion. They previously proved that the expression of ldh gene rises in response to ischemia (Karaca et al, 2006;Xu et al, 2006), but at the same time our results have shown that in response to normoxic perfusion LDH was down- Hemodynamic parameters, like coronary flow and heart rate were also measured. None of these parameters changed in the perfused groups when compared to controls.…”

The effect of isosteviol on hyperglycemia and dyslipidemia induced by lipotoxicity in rats fed with high-fat emulsion

“…1) is an acid hydrolysate of stevioside. We have reported that isosteviol can alleviate the injury induced by ischemia-reperfusion in isolated perfused guinea pig heart (Xu et al, 2007b), rat heart in vivo (Xu et al, 2007a) and rat brain in vivo (Xu et al, 2008). We also found that isosteviol was able to reduce plasma glucose concentrations but did not have an impact on plasma insulin levels during an intravenous glucose tolerance test in Zucker diabetic fatty rats (Ma et al, 2007).…”

A labdane diterpene exerts ex vivo and in vivo cardioprotection against post-ischemic injury: Involvement of AKT-dependent mechanisms

“…Diverse labdane-type diterpenes with anti-inflammatory properties have been described in the literature [13,17,[30][31][32][33]. In addition, some labdane diterpenes exert cytoprotective activities, although few studies have evaluated the therapeutic potential of terpenes in cardioprotection [16,29,34,35]. In the context of drug discovery, development of new compounds targeting different pathways and acting as multi-target inhibitors may provide new strategies for cardiovascular therapy [36].…”