The cardiac fibroblast: Origin, identity and role in homeostasis and disease

Furtado, Milena B.; Costa, Mauro W.; Rosenthal, Nadia

doi:10.1016/j.diff.2016.06.004

Cited by 37 publications

(46 citation statements)

References 91 publications

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“…Cardiac fibroblasts (CFs) play key roles in myocardium homeostasis and in response to injury. CFs are the main cell type involved in the synthesis and turnover of extracellular matrix (ECM) and they function as local immune modulators, and are part of the cardiac electrophysiology network . Upon myocardial injury and other cardiac pathologies, CFs undergo activation (differentiation to myofibroblasts), proliferate, and produce an excess of ECM, a process referred to as fibrosis.…”

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confidence: 99%

“…Upon myocardial injury and other cardiac pathologies, CFs undergo activation (differentiation to myofibroblasts), proliferate, and produce an excess of ECM, a process referred to as fibrosis. Fibrotic tissue is stiffer and less conductive, which leads to impaired normal heart function, with increased tissue workload and arrhythmias . Fibrosis is a pathological feature present in numerous forms of heart diseases: it is estimated that about 45% of all deaths in the developed world involve cardiac fibrosis …”

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“…Due to their central role in cardiac fibrosis, a lot of attention has been drawn to the study of CFs. Although some progress was made recently, the lack of a proper molecular definition enabling an accurate identification of these cells has been one of the major impediments to CF research. Some of the most commonly used markers for CFs characterization are collagens, vimentin, discoidin domain receptor (DDR2), Thy1 antigen (CD90), and smooth muscle actinin (SMA).…”

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confidence: 99%

“…Some of the most commonly used markers for CFs characterization are collagens, vimentin, discoidin domain receptor (DDR2), Thy1 antigen (CD90), and smooth muscle actinin (SMA). None of these molecules are either expressed by all CFs or unique for this cell type . Recently, a novel antibody mEF‐SK4 (unknown antigen) has been identified as a robust fibroblast marker of the adult mice heart, but unfortunately, this antibody is not suitable for human cells …”

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Unveiling Human Cardiac Fibroblast Membrane Proteome

et al. 2018

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Cardiac fibroblasts (CFs) are one of the main cell populations in the heart and play important roles in tissue homeostasis and myocardial fibrosis. The study of these cells has been hampered by the lack of reliable membrane markers: none of the antigens currently used for characterization and isolation of CFs is unique for this cell type. This issue has also raised doubts regarding a distinct identity of cardiac fibroblasts when compared to other myocardium cell populations with similar morphologies. In this work, we report a comprehensive description and functional analysis of human CFs (hCFs) membraneenriched fraction proteome by advanced mass spectrometry-based proteomic tools. A total number of 1478 proteins were identified, including 774 membrane proteins (52%). We also report the identification of a subset of 30 membrane proteins that in this workflow were only identified in hCFs by comparison with the membrane-enriched proteome lists of human cardiac stem cells, human mesenchymal stem cells, and human dermal fibroblasts. The data reported in this work are a valuable source of information for further studies aiming at defining a membrane molecular signature of human cardiac fibroblasts (hCFs), and a step forward in research regarding membrane proteins with key roles in hCF function in homeostasis and disease.

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Unveiling Human Cardiac Fibroblast Membrane Proteome

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“…As proliferative activity in the myocardium is limited, remodeling is largely based on conformational changes of the myocyte (66). The process also involves changes of the extracellular matrix due to fibroblast activity as well as changes in cellular homeostasis (67). The mechanisms of cellular growth are not completely clear, but it is believed that aspects of mechanotransduction, when myocytes and extracellular matrix stretch, are involved (66).…”

Section: Cardiac Remodeling and Hypertrophymentioning

confidence: 99%

Blood flow specific assessment of ventricular function: Visualization and quantification using 4D flow CMR

Fredriksson¹

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Development of the Myocardial Interstitium

Pogontke

Guadix

Ruiz‐Villalba

et al. 2018

The Anatomical Record

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The space between cardiac myocytes is commonly referred‐to as the cardiac interstitium (CI). The CI is a unique, complex and dynamic microenvironment in which multiple cell types, extracellular matrix molecules, and instructive signals interact to crucially support heart homeostasis and promote cardiac responses to normal and pathologic stimuli. Despite the biomedical and clinical relevance of the CI, its detailed cellular structure remains to be elucidated. In this review, we will dissect the organization of the cardiac interstitium by following its changing cellular and molecular composition from embryonic developmental stages to adulthood, providing a systematic analysis of the biological components of the CI. The main goal of this review is to contribute to our understanding of the CI roles in health and disease. Anat Rec, 302:58–68, 2019. © 2018 Wiley Periodicals, Inc.

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The cardiac fibroblast: Origin, identity and role in homeostasis and disease

Cited by 37 publications

References 91 publications

Unveiling Human Cardiac Fibroblast Membrane Proteome

Unveiling Human Cardiac Fibroblast Membrane Proteome

Blood flow specific assessment of ventricular function: Visualization and quantification using 4D flow CMR

Development of the Myocardial Interstitium

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