The caper (Capparis L.): Ethnopharmacology, phytochemical and pharmacological properties

Tlili, Nizar; Elfalleh, Walid; Saadaoui, Ezzeddine; Khaldi, Abdelhamid; Triki, Saïda; Nasri, Nizar

doi:10.1016/j.fitote.2010.09.006

Cited by 139 publications

(127 citation statements)

References 91 publications

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“…Its fruit, roots, and barks are used for medical purposes. In traditional medicine, this plant is used as a diuretic and for the treatment of gout, rheumatism, and liver disease (4). Previously, the analgesic, anti-inflammatory, antihepatotoxicity, hypolipidemic, and anti-allergic effects of this plant have been reported (5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of the Hydroalcoholic Extract of Capparis spinosa L. Against Cyclophosphamide-Induced Nephrotoxicity in Mice

Kalantar

Goudarzi

Khodayar

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: Cyclophosphamide (CP) is one of the most popular alkylating anticancer drugs despite its toxic side effects, including nephrotoxicity, hematotoxicity, mutagenicity, and immunotoxicity. Capparis spinosa is a multipurpose plant that contains a number of chemically active and diverse secondary metabolites, particularly flavonoids. Rutin and quercetin are two major flavonoids in the caper plant. Objectives: This study was undertaken to investigate the protective effect of Capparis spinosa L. extract on nephrotoxicity induced by cyclophosphamide in mice. Methods: In this experimental study, 40 male Swiss albino mice (20 -25 g) were randomly divided into five groups with each group consisting of eight mice. Mice were pretreated with C. spinosa extract (CSE) orally in doses of 100, 200 and 400 mg/kg for five consecutive days, and CP (200 mg/kg, ip) was administrated on the fifth day 1 hour after the last dose of extract. The animals were sacrificed on the sixth day. Blood samples were collected to determine the serum creatinine (Cr) and blood urea nitrogen (BUN) levels. The malondialdehyde (MDA) and glutathione (GSH) levels were assayed in kidney tissue. The right kidney was maintained in 10% formalin for hematoxylin and eosin staining and histological examination. Results: Different plant parts (fruit, leaves, and petals) were examined for antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl assay, and leaf extract was used to determine nephroprotective effects. Results showed a significant increase in the levels of MDA, Cr, and BUN and a reduction of GSH by CP administration. Pre-treatment with CSE decreased the levels of MDA, Cr, and BUN. GSH increased in all doses, but the most significant alteration was observed in the doses of 200 and 400 mg/kg (P < 0.05). The nephroprotective effect of the CSE was confirmed by the histological examination of the kidneys. Conclusions: Our results indicate that CSE ameliorates biochemical indices and oxidative stress parameters against CP-induced nephrotoxicity.

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Section: Introductionmentioning

confidence: 99%

Protective Effects of the Hydroalcoholic Extract of Capparis spinosa L. Against Cyclophosphamide-Induced Nephrotoxicity in Mice

Kalantar

Goudarzi

Khodayar

et al. 2016

Jundishapur J Nat Pharm Prod

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“…Biyolojik çalışmalar önemli antimikrobiyal, antioksidan, anti-inflamatuar ve antiviral özellikleri olduğunu göstermiştir. Çeşitli hastalıkların tedavisinde geleneksel ilaç olarak kullanılmıştır (12). Capparis spinosa'nın kimyasal bileşimi ile ilgili çalışmalarda alkaloidler, lipidler, polifenoller, flavonoidler ve glukosinolatlar varlığı tespit edilmiştir.…”

Section: Discussionunclassified

Effectiveness of the Capparis spinosa Treatment in Vitiligo

EMIROGLU¹,

CENGİZ²,

BAHALI³

et al. 2018

Bezmialem Science

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Objective: We aim to compare the efficacy of topical steroids and Capparis spinosa extract in the treatment of vitiligo. Methods: Patients were retrospectively identified from those treated by the Department of Dermatology. 60 vitiligo patients were included in the study. 30 of them were given topical steroids, and 30 of them were treated with Capparis spinosa extract. VASI (Vitiligo Area Scoring Index) were calculated statistically before treatment and during the 6. month of treatment. Results: Although the VASI value of patients who treated with topical corticosteroids decreased statistically, no statistically significant changes were observed in patients who treated with with Capparis spinosa extract. After treatment, VASI values were significantly lower in patients with treated topical corticosteroids than treated with Capparis spinosa extract (p<0.05). Discussion: In this study, topical corticosteroids were more effective than Capparis spinosa in the treatment of vitiligo. Although there was not statistically difference of VASI values in patients treated with Capparis spinosa. repigmentation was observed after treatment. Therefore Capparis spinosa is not enough alone but maybe it can be used in combination therapy of vitiligo. Keywords: Vitiligo, treatment, Capparis spinosa ÖZ Amaç: Vitiligoda Capparis spinosa ekstresinin etkinliğini ve bu etkinliği topikal steroid tedavisi ile kıyaslanmayı amaçladık. Yöntemler: Cildiye Polikliniğinde muayene edilen vitiligolu bireylerin tedavisi retrospektif olarak tarandı. Altmış vitiligolu hasta çalış-maya dahil edildi. Otuzuna topikal kortikosteroid, 30'una ise topikal Capparis spinosa ekstresi verildi. Hastaların tedavi öncesi ve tedavinin 6. ayındaki VASI'si (Vitiligo Area Scoring Index) hesaplandı ve istatistiksel olarak kıyaslandı. Bulgular: Topikal Capparis spinosa tedavisi alan hastaların VASI değerlerinde, tedavi sonrası tedavi öncesine göre istatistiksel olarak anlamlı bir değişiklik gözlenmedi (p>0.05). Topikal kortikosteroid tedavisi alan hastaların tedavi sonrası VASI'lerinde anlamlı bir azalma görüldü (p<0.05). Tedavi sonrasında topikal kortikosteroid tedavisi alan hastaların VASI değerleri topikal Capparis spinosa tedavisi alanlara göre anlamlı olarak düşüktü (p<0.05). Sonuç: Bu çalışmada vitiligo tedavisinde yeni bir seçenek olan olan Capparis spinosa ekstresinin etkinliğini topikal kortikosteroidler ile karşılaştırdığımızda topikal kortikosteroidler daha etkin görülmekteydi ancak Capparis spinosa kullanan hastalarda da repigmentasyon izlenmesi tek başına olmasa bile kombinasyon tedavilerinde kullanılabilecek bir ajan olduğunu düşündürdü. Anahtar Kelimeler: Vitiligo, tedavi, Capparis spinosa Nazan EMİROĞLU, Fatma Pelin CENGİZ, Anıl GÜLSEL BAHALI, Dilek BIYIK ÖZKAYA, Özlem SU, Nahide ONSUN Department of Dermatology, Bezmialem Vakıf University School of Medicine, İstanbul, Turkey GirişVitiligo nedeni bilinmeyen, edinilmiş, deride fonksiyonel melanositlerde kayıp görülen klinik olarak depigmente makül ve yamalarla seyreden bir hastalıktır. Toplumda gö...

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“…26 It has been used in traditional medicine for the treatment of various diseases. It possesses antioxidant, anti-inflammatory, antimicrobial, antiviral, and immunomodulatory properties.…”

Section: Capparis Spinosa Lmentioning

confidence: 99%

“…It possesses antioxidant, anti-inflammatory, antimicrobial, antiviral, and immunomodulatory properties. 26 Bonina et al 27 conducted an in vitro study showing that CS does possess antioxidant properties. They then evaluated the ability of topically applied lyophilized extract of CS (LECS) to reduce UVB induced skin erythema in six healthy subjects of both sexes, aged 25-35 years.…”

Section: Capparis Spinosa Lmentioning

confidence: 99%

Systematic Review of Oral and Topical Botanicals in Reducing Photosensitivity

Saric¹,

Clark²,

Sivamani³

2017

Dermatol Open J

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CitationSaric S, Clark AK, Sivamani RK. Systematic review of oral and topical botanicals in reducing photosensitivity. Dermatol Open J. 2017; 2(2): 21-30. doi: 10.17140/DRMTOJ-2-124 ABSTRACT Objectives: Various treatment options are available for the management of photosensitivity. The objective of this review is to evaluate the use of botanicals rich in antioxidants for photosensitivity reduction. Design: Embase and Ovid/MEDLINE databases were searched for clinical studies evaluating antioxidants from botanical sources in the management of photosensitivity. Results: Of 339 citations, 10 met the inclusion criteria. Four studies evaluated Polypodium leucotomos, two evaluated Camelia sinensis, while Hamamelis, Pistacia vera L., Citrus sinensis varieties Moro, Tarocco and Sanguinello, and Capparis spinosa were investigated in one study each. Five studies evaluated oral supplementation, four evaluated topical formulations, and one study evaluated both oral and topical antioxidants. Main results were summarized. Conclusions: There is some evidence that antioxidants derived from botanical sources may be beneficial in reducing skin erythema and photosensitivity. However, the studies included in this review have methodological limitations and large scale randomized, placebo controlled trials are needed to further evaluate the efficacy and safety of botanical antioxidants in photosensitivity reduction.

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The caper (Capparis L.): Ethnopharmacology, phytochemical and pharmacological properties

Cited by 139 publications

References 91 publications

Protective Effects of the Hydroalcoholic Extract of Capparis spinosa L. Against Cyclophosphamide-Induced Nephrotoxicity in Mice

Protective Effects of the Hydroalcoholic Extract of Capparis spinosa L. Against Cyclophosphamide-Induced Nephrotoxicity in Mice

Effectiveness of the Capparis spinosa Treatment in Vitiligo

Systematic Review of Oral and Topical Botanicals in Reducing Photosensitivity

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