The Capacity of Manno-Oligosaccharides, Thermolysed Yeast and Active Yeast to Attenuate Aflatoxicosis

Baptista, Antonio Sampaio; Horii, Jorge; Calori‐Domingues, Maria Antonia; Glória, Eduardo Micotti da; Salgado, Jocelem Mastrodi; Vizioli, Mário Roberto

doi:10.1023/b:wibi.0000040397.48873.3b

Cited by 54 publications

(12 citation statements)

References 16 publications

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“…These results are consistent with those reported by Baptista et al (2004), who found that albino Wistar rats fed aflatoxincontaminated diets did not show a reduction in food consumption or a decrease in weight gain. These results could be explained by the fact that rats are tolerant to aflatoxin effects (Barnes and Butler 1964), even though some authors have reported that the most common clinical symptoms are anorexia, reduction in weight gain and food conversion (Dickens and Jones 1963;Edds and Bortell 1983;Huff et al 1986;Kubena et al 1990).…”

Section: Nutritional Evaluation and Relative Weight Of The Internal Osupporting

confidence: 95%

“…The hepatocytes showed signs of degeneration, retention of pigments, and necrosis. These results are in agreement with those reported by Heathcote and Hibbert (1978), Baptista et al (2004) and Celik et al (2003), who documented cellular disorganization with proliferation of the bile ducts, necrosis of the hepatic parenchyma, vacuolization, swollen hepatocytes, fat degeneration and retention of pigments in liver tissues of animals that were fed diets with aflatoxins. These data suggest that the dose of aflatoxin given and the exposure time were sufficient to cause hepatotoxicity in the animals.…”

Section: Biochemical Analysissupporting

confidence: 95%

“…No report was found in the literature about the usage of Y904 as an aflatoxicosis treatment. However, the results obtained with Y904 are similar to those obtained with yeast strain Y1026 by Stanley et al (1993), Parlat et al (2001) and Baptista et al (2004), who reported a reduction of aflatoxicosis. These data indicate that the strain of the active Saccharomyces cerevisiae cells used is perhaps not the most important factor to prevent aflatoxicosis, since studies utilizing different strains of yeast cells revealed similar positive results.…”

Section: Biochemical Analysissupporting

confidence: 92%

“…On the other hand, Stanley et al (1993) reported that the relative weights of the internal organs (liver, heart and kidneys) from chickens fed contaminated diets containing 5 mg kg -1 of aflatoxins for 28 days were greater than those from chickens fed an aflatoxin-free diet for the same period. These differences could be caused by two factors: (1) different quantities of aflatoxins given to the animals, i.e., in the study conducted by Stanley et al (1993), chickens were fed diets containing 5 mg of aflatoxins per kg of diet, while in this study, Wistar rats were fed diets containing 400 lg of aflatoxins per kg of diet, and (2) rats have a different sensitivity to aflatoxin than chickens, since Baptista et al (2004), using Wistar rats, observed similar results to this study.…”

Section: Nutritional Evaluation and Relative Weight Of The Internal Omentioning

confidence: 99%

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Utilization of diets amended with yeast and amino acids for the control of aflatoxicosis

Baptista¹,

Abdalla²,

Aguiar³

et al. 2008

World J Microbiol Biotechnol

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Although the effects of aflatoxin on animal performance have been well established in previous studies, there are few studies reporting on the relationship between aflatoxin and Saccharomyces cerevisiae. The ability of Saccharomyces cerevisiae to minimize aflatoxicosis was evaluated. An aflatoxin-free diet and six contaminated diets (400 lg kg -1 aflatoxin) were formulated with five diets containing the viable yeast (Y1026 or Y904). A 28-day bioassay using 21-day-old and 60-g body weight Wistar rats was conducted. The results showed that there were no significant (P [ 0.05) differences for: food consumption; daily weight gain; food conversion, and enzyme activity. Hepatic tissues from the aflatoxin control group suffered from hepatotoxicity, cellular disorganization, and hepatocyte necrosis. The inclusion of yeast or yeast and amino acids (methionine and cysteine) reduced the toxicity.

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Section: Nutritional Evaluation and Relative Weight Of The Internal Osupporting

confidence: 95%

Section: Biochemical Analysissupporting

confidence: 95%

Section: Biochemical Analysissupporting

confidence: 92%

Section: Nutritional Evaluation and Relative Weight Of The Internal Omentioning

confidence: 99%

See 2 more Smart Citations

Utilization of diets amended with yeast and amino acids for the control of aflatoxicosis

Baptista¹,

Abdalla²,

Aguiar³

et al. 2008

World J Microbiol Biotechnol

View full text Add to dashboard Cite

show abstract

“…The mechanism of removing mycotoxins from the environment by microorganisms has not been thoroughly explained so far. It arises from the available literature that in the case of LAB and yeast, it is the result of cell wall adhesion, which is additionally confirmed by the fact that even dead cells preserve the said activity [27,28].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Probiotic Supplementation on Performance and the Histopathological Changes in Liver and Kidneys in Broiler Chickens Fed Diets with Aflatoxin B1

Śliżewska

Cukrowská

Smulikowska

et al. 2019

Toxins

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The aim of the study was to investigate the toxic effects of aflatoxin B1 (AFB1) and efficacy of a probiotic preparation containing L. reuteri, L. plantarum, L. pentosus, L. rhamnosus and L. paracasei and Saccharomyces cerevisiae yeasts to ameliorate their effects in broiler chickens. A total of 168 one-day-old female Ross 308 broilers were randomly allocated to six groups. Three wheat and soybean meal-based diets were prepared: Control diet and diets contaminated with 1 or 5 mg/kg AFB1 supplied in moldy wheat. All diets were unsupplemented or supplemented with probiotic, cold pelleted and fed from 1 to 35 day of life. Feeding diet with 1 mg AFB1/kg did not affect performance, but a diet with 5 mg AFB1 resulted in a significant reduction of feed intake and BWG, both diets induced liver and kidneys enlargement. The probiotic supplementation of the diets partially ameliorated those negative effects and resulted in a significant increase of AFB1 excretion. It was accompanied by the reduced level of AFB1 residues in the liver from 8.9 to 3.7 and from 11.8 to 5.9 µg/kg, in kidneys from 7.9 to 2.5 and from 13.7 to 4.1 µg/kg in birds fed the less and more contaminated diets, respectively. AFB1 exposure caused many severe histopathological changes in the liver and kidneys of broilers, probiotic supplementation significantly reduced the changes of these organs. It may be concluded that the probiotic supplementation can be used to alleviate the negative effects of contamination of broiler feed with AFB1 on bird health and product security.

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Effect of dietary macronutrients on aflatoxicosis: a mini‐review

Adilah

Sabran

2017

J Sci Food Agric

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Aflatoxin is a toxin produced by Aspergillus species of fungi. The main route of aflatoxin exposure is through the diet. Indeed, long-term aflatoxin exposure is linked to the development of hepatocellular carcinoma (HCC). Aflatoxin causes aflatoxicosis, which can be affected by several factors and is prevalent in many developing Asian and African countries. This mini-review discusses the effects of carbohydrate, fat and protein on aflatoxicosis based on findings from animal and human studies. It was found that high carbohydrate intake enhanced aflatoxicosis occurrence, while low ingestion of carbohydrate with caloric restriction slowed the symptoms associated with aflatoxicosis. Additionally, diets with low protein content worsened the symptoms related to HCC due to aflatoxin exposure. Nevertheless, a study reported that a high-protein diet favored detoxification of aflatoxin in vivo. There were also conflicting results on the influence of dietary fat, as high ingestion of fat enhanced aflatoxicosis development as compared with a low-fat diet. Moreover, the type of fat also plays a significant role in influencing aflatoxin toxicity. In regard to food safety, understanding the influence of macronutrients toward the progression of aflatoxicosis can improve preventive measures against human and animal exposure to aflatoxin. © 2017 Society of Chemical Industry.

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The Capacity of Manno-Oligosaccharides, Thermolysed Yeast and Active Yeast to Attenuate Aflatoxicosis

Cited by 54 publications

References 16 publications

Utilization of diets amended with yeast and amino acids for the control of aflatoxicosis

Utilization of diets amended with yeast and amino acids for the control of aflatoxicosis

The Effect of Probiotic Supplementation on Performance and the Histopathological Changes in Liver and Kidneys in Broiler Chickens Fed Diets with Aflatoxin B1

Effect of dietary macronutrients on aflatoxicosis: a mini‐review

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