2015
DOI: 10.1038/524280a
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The cannabis experiment

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Cited by 25 publications
(15 citation statements)
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“…In addition to an increasing awareness of the existence of the CWS, its increasing emergence in the last 20 years might result from the increasing psychotropic potency of the used marijuana originating from the breeding of strains with high THC (10%–18.5%) and low cannabidiol concentrations (<0.15%) being found especially in high-income countries 1,8890,122. In the Netherlands, the recent cannabidiol content of imported resin was ~7% 90.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In addition to an increasing awareness of the existence of the CWS, its increasing emergence in the last 20 years might result from the increasing psychotropic potency of the used marijuana originating from the breeding of strains with high THC (10%–18.5%) and low cannabidiol concentrations (<0.15%) being found especially in high-income countries 1,8890,122. In the Netherlands, the recent cannabidiol content of imported resin was ~7% 90.…”
Section: Discussionmentioning
confidence: 99%
“…Since the early 1950s, it is known that the chemical composition of the resin itself varies with cannabidiol activities between 0% and 50% depending on the provenance of the drug 87. Whether the users of more potent cannabis strains adjust their intake according to the potency is still unclear 88. However, there is first evidence that the occurrence of first-episode psychosis as well as the intensity of the CUD increased alongside the use of high potency cannabis preparations 124,125.…”
Section: Discussionmentioning
confidence: 99%
“…Cannabinoids intake is estimated to be 181.8 million cannabis users worldwide [4]. Cannabis potency also increased from 3–4% to >10% over the last two decades with some regional differences [4–6]. The ability to genetically select strains with high cannabis potency contributed to the dramatic increase in Δ 9 -tetrahydracannabinol (THC), the primary psychoactive ingredient in cannabis [4, 7].…”
Section: Introductionmentioning
confidence: 99%
“…Cannabis use is an important global public health issue, and a growing topic of controversy and debate 1; 2 . It is the most widely used illicit psychoactive substance in the world 3 , and the potential medicinal and therapeutic benefits of cannabis and its main active ingredients tetrahydrocannabinol (THC) and cannabidiol (CBD) are gaining interest 4–6 .…”
Section: Introductionmentioning
confidence: 99%