The cannabinoid receptor 2 agonist β-caryophyllene reduces voluntary alcohol intake and attenuated ethanol-induced place preference and sensitivity in mice

Mansouri, Shamma Al; Ojha, Sudarshan; Maamari, Elyazia Al; Ameri, Mouza Al; Nurulain, SM; Bahí, Amine

doi:10.7707/hmj.490

Hamdan Medical Journal

2015

DOI: 10.7707/hmj.490

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The cannabinoid receptor 2 agonist β-caryophyllene reduces voluntary alcohol intake and attenuated ethanol-induced place preference and sensitivity in mice

Shamma Al Mansouri¹,

Sudarshan Ojha²,

Elyazia Al Maamari³

et al.

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“…22 β-Caryophyllene is generally dispersed in the EOs of various plants (Myrica gale, Eugenia caryophyllata, and Comptonia peregrina). Numerous biological activities, such as local anesthetic, anticarcinogenic, antioxidant, antibiotic, and anti-inflammatory, 23 anxiolytic and antialcoholic, 24 antidepressant, 25 neuroprotective, 26 and antinociceptive activities, 27 are recognized for β-caryophyllene.…”

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Essential Oil From Psidium guajava Leaves: An Excellent Source of β-Caryophyllene

Arain

Sherazi

Mahesar

et al. 2019

Natural Product Communications

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The purpose of this study was to investigate the chemical composition of the essential oil extracted from Psidium guajava leaves and to explore the medicinal value of β-caryophyllene in pharmaceutical science. The essential oils of P. guajava leaves were extracted by the hydrodistillation method, using a Clevenger-type apparatus and the chemical composition of essential oils was investigated by gas chromatography-mass spectrometry. The yield of extracted essential oils was 0.6% (w/w) dry weight. The main compounds found in the leaves were β-caryophyllene (20.34%), globulol (8.20%), trans-nerolidol (7.72%), aromadendrene (4.34%), cis-α-bisabolene (3.82%), tetracosane (3.68%), octadecane (3.66%), Z,Z,Z-1,5,9,9-tetramethyl-1,4,7cycloundecatriene (3.44%), β-bisabolene (3.41%), limonene (3.09%), octacosane (2.88%), δ-cadinene (2.52%), and 1,4-cadadiene (2.04%). The main chemical class of the essential oil was terpenoids, which represent 71.65%, followed by hydrocarbons (26.31%). A total of 50 components were identified, among these β-caryophyllene was found to be dominant, which has great medicinal value, and some other compounds were also identified for the first time in the essential oil of P. guajava leaves.

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confidence: 99%

Essential Oil From Psidium guajava Leaves: An Excellent Source of β-Caryophyllene

Arain

Sherazi

Mahesar

et al. 2019

Natural Product Communications

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The cannabinoid receptor 2 agonist β-caryophyllene reduces voluntary alcohol intake and attenuated ethanol-induced place preference and sensitivity in mice

Cited by 1 publication

References 0 publications

Essential Oil From Psidium guajava Leaves: An Excellent Source of β-Caryophyllene

Essential Oil From Psidium guajava Leaves: An Excellent Source of β-Caryophyllene

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