Abstract:The California Verbal Learning Test (CVLT) is a popular clinical and research test that claims to measure key constructs in cognitive psychology such as repetition learning, serial position effects, semantic organization, intrusions, and proactive interference. The psychometric characteristics of the CVLT are reviewed and related to the test's clinical utility. The utility of the CVLT is shown to be limited by its poor standardization and inflated norms. Further, the validity is limited because the CVLT uses m… Show more
“…In brief, the neurocognitive tests used included the Controlled Oral Word Association (COWA), 25 Trail Making Test parts A and B, 26 a 24-point modified version of the ReyOsterreith Complex Figure (ROCF), 27 and Digit Span test. 28 In WFU 97100, the California Verbal Learning Test (CVLT) 29 was used. In WFU 91105, the CVLT was replaced by the Hopkins Verbal Learning Test-Revised.…”
Objective: In a retrospective review to assess neuroanatomical targets of radiation-induced cognitive decline, dose volume histogram (DVH) analyses of specific brain regions of interest (ROI) are correlated to neurocognitive performance in 57 primary brain tumor survivors.Methods: Neurocognitive assessment at baseline included Trail Making Tests A/B, a modified Rey-Osterreith Complex Figure, California or Hopkins Verbal Learning Test, Digit Span, and Controlled Oral Word Association. DVH analysis was performed for multiple neuroanatomical targets considered to be involved in cognition. The %v10 (percent of ROI receiving 10 Gy), %v40, and %v60 were calculated for each ROI. Factor analysis was used to estimate global cognition based on a summary of performance on individual cognitive tests. Stepwise regression was used to determine which dose volume predicted performance on global factors and individual neurocognitive tests for each ROI.Results: Regions that predicted global cognitive outcomes at doses ,60 Gy included the corpus callosum, left frontal white matter, right temporal lobe, bilateral hippocampi, subventricular zone, and cerebellum. Regions of adult neurogenesis primarily predicted cognition at %v40 except for the right hippocampus which predicted at %v10. Regions that did not predict global cognitive outcomes at any dose include total brain volume, frontal pole, anterior cingulate, right frontal white matter, and the right precentral gyrus.
Conclusions:Modeling of radiation-induced cognitive decline using neuroanatomical target theory appears to be feasible. A prospective trial is necessary to validate these data. Neurology Figure; RT 5 radiotherapy; SVZ 5 subventricular zone; WBI 5 whole-brain irradiation.
“…In brief, the neurocognitive tests used included the Controlled Oral Word Association (COWA), 25 Trail Making Test parts A and B, 26 a 24-point modified version of the ReyOsterreith Complex Figure (ROCF), 27 and Digit Span test. 28 In WFU 97100, the California Verbal Learning Test (CVLT) 29 was used. In WFU 91105, the CVLT was replaced by the Hopkins Verbal Learning Test-Revised.…”
Objective: In a retrospective review to assess neuroanatomical targets of radiation-induced cognitive decline, dose volume histogram (DVH) analyses of specific brain regions of interest (ROI) are correlated to neurocognitive performance in 57 primary brain tumor survivors.Methods: Neurocognitive assessment at baseline included Trail Making Tests A/B, a modified Rey-Osterreith Complex Figure, California or Hopkins Verbal Learning Test, Digit Span, and Controlled Oral Word Association. DVH analysis was performed for multiple neuroanatomical targets considered to be involved in cognition. The %v10 (percent of ROI receiving 10 Gy), %v40, and %v60 were calculated for each ROI. Factor analysis was used to estimate global cognition based on a summary of performance on individual cognitive tests. Stepwise regression was used to determine which dose volume predicted performance on global factors and individual neurocognitive tests for each ROI.Results: Regions that predicted global cognitive outcomes at doses ,60 Gy included the corpus callosum, left frontal white matter, right temporal lobe, bilateral hippocampi, subventricular zone, and cerebellum. Regions of adult neurogenesis primarily predicted cognition at %v40 except for the right hippocampus which predicted at %v10. Regions that did not predict global cognitive outcomes at any dose include total brain volume, frontal pole, anterior cingulate, right frontal white matter, and the right precentral gyrus.
Conclusions:Modeling of radiation-induced cognitive decline using neuroanatomical target theory appears to be feasible. A prospective trial is necessary to validate these data. Neurology Figure; RT 5 radiotherapy; SVZ 5 subventricular zone; WBI 5 whole-brain irradiation.
“…33 It measures repetition learning, serial position effects, semantic organization, intrusions, and proactive interference, which are the key constructs in cognitive psychology. 35 The CVLT produces a wide variety of measures, including immediate memory, short delay free recall, short delay cued recall, long delay free recall, long delay cued recall, and long delay recognition.…”
Section: California Verbal Learning Test (Persian)mentioning
Objectives: Patients with end-stage liver disease face various psychologic challenges. We aimed to compare levels of depression, anxiety, fatigue, sleepiness, and memory in patients before and after liver transplant. Materials and Methods: Forty patients (24 male, 16 female) were recruited from the liver transplant clinic affiliated with Shiraz University of Medical Sciences. Patients between 18 and 60 years old with at least a 6th-grade level of education were included in the study; those with severe psychiatric problems were excluded. We performed the following assessments before and 1 month after liver transplant: Hospital Anxiety and Depression questionnaires, California Verbal Learning Test, Epworth Sleepiness Scale, and Fatigue Severity Scale. Paired-sample t tests were used. P < .05 was considered significant. Results: Level of depression in study patients increased after transplant (7.42 vs 8.42; P = .008). We found improvements in categories of immediate memory (65.23 vs 60; P = .007), short delay free recall (10.52 vs 12.52; P < .001), short delay cued recall (11.42 vs 13.00; P = .001), long delay free recall (10.80 vs 12.50; P = .003), long delay cued recall (11.80 vs 13.25; P = .003), and recognition (14.65 vs 15.42; P = .003).Patient levels of fatigue (39.9 vs 33.2; P = .029) and sleepiness (10.8 vs 7.8; P = .004) decreased. Level of anxiety did not change significantly (12.6 vs 12.8; P = .642).
Conclusions:We observed higher levels of depression but improved fatigue, sleepiness, and memory function in patients after liver transplant. No significant change in patient level of anxiety was seen. Future direction is discussed.
“…Adicionalmente, se utilizaron otras pruebas como el Test de Aprendizaje Verbal California (Elwood, 1995) para evaluar aprendizaje y memoria; una sub-prueba de dígitos en reverso de la escala de inteligencia Weschsler para adultos (WAIS-III, Wechsler, 1999) para valorar atención; la prueba de la Figura Compleja de Rey-Osterrieth (Rey, 1942) relacionada con habilidad visoconstructiva; y el Test de búsqueda de símbolos de WAIS III (Weschsler, 1999) para evaluar la velocidad de procesamiento de la información. Finalmente, también se aplicó el Inventario de depresión de Beck (Jurado et al, 1998), y el Inventario de apatía de Marín (Marin, Bidrzycki, & Firinciogullari, 1991), con el fin de igualar los grupos de estudio y de referencia con respecto a su estado de ánimo y apatía.…”
ResumenExiste poca evidencia del deterioro cognoscitivo que defina el perfil del paciente con Infarto Lacunar (IL). El propósito de este estudio fue identificar las alteraciones neuropsicológicas en este tipo de pacientes. La muestra estuvo compuesta por 16 pacientes con IL y 16 participantes sanos con una edad promedio de 63 ± 9.41 y 64.75 ± 9.06 años y una escolaridad de 7.55 ± 4.34 y 7.94 ± 3.51, respectivamente. Se valoró la función cognoscitiva mediante un instrumento de tamizaje y una batería neuropsicológica. El análisis estadístico se llevó a cabo a través de la prueba Kruskal-Wallis y la U de Man-Whitney. Los pacientes con IL se caracterizan por la alteración de dominios como planeación, fluidez verbal, cambio atencional, habilidad visoconstructiva y velocidad de procesamiento de la información (p < 0.050). El IL se relaciona con el deterioro del funcionamiento ejecutivo y de velocidad de procesamiento, debido a la interrupción de circuitos frontocortico-subcorticales asociados con su correcto desempeño. Palabras clave: Deterioro Cognoscitivo Vascular, cápsula interna, corona radiada, tallo encefálico, infarto cerebral, neuropsicología.
NEUROPSYCHOLOGICAL DISORDERS ASSOCIATED WITH PATIENTS WITH LACUNAR INFARCT
AbstractThere is little evidence of cognitive impairment to define the profile of patients with Lacunar Infarction (IL). The purpose of this study was to identify the neuropsychological disorders in these patients. The sample consisted of 16 patients with IL and 16 healthy control participants with an average age of 63 ± 9.41 and 64.75 ± 9.06 years, and average schooling of 7.55 ± 4.34 and 7.94 ± 3.51, respectively. Cognitive function was assessed using a screening tool and a neuropsychological battery. Statistical analysis was carried out by the Kruskal-Wallis and Mann-Whitney U tests. Patients with IL are characterized by the alteration of domains such as planning, verbal fluency, attention switching, visoconstructive skill and information processing speed (p <0.050). The IL is related to the impairment of executive functioning and processing speed, due to the interruption of frontocortico-subcortical circuits associated with their proper performance.
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