The Caenorhabditis elegans male: Postembryonic development of nongonadal structures

Sulston, JE; Albertson, Donna G.; Thomson, J. N.

doi:10.1016/0012-1606(80)90352-8

Cited by 537 publications

(541 citation statements)

References 10 publications

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“…This behavior is carried out by 87 neurons exclusive to the male; 42 of these neurons are ciliated neurons in the tail and many of these may be mechanoreceptors [79]. Two TRPP proteins, the polycystinlike proteins LOV-1 and PKD-2, are expressed in a subset of these neurons and required for male mating response and vulva location [4,5,54].…”

Section: Other Mechanosensory Behaviorsmentioning

confidence: 99%

Touch sensitivity in Caenorhabditis elegans

Bounoutas

Chalfie

2007

Pflugers Arch - Eur J Physiol

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The nematode Caenorhabditis elegans was the first organism for which touch insensitive mutants were obtained. The study of the genes defective in these mutants has led to the identification of components of a mechanosensory complex needed for specific cells to sense gentle touch to the body. Multiple approaches using genetics, cell biology, biochemistry, and electrophysiology have characterized a channel complex, containing two DEG/ENaC pore-forming subunits and several other proteins, that transduces the touch response. Other mechanical responses, sensed by other cells using a variety of other components, are less well understood in C. elegans. Many of these other senses may use TRP channels, although DEG/ENaC channels have also been implicated.

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Section: Other Mechanosensory Behaviorsmentioning

confidence: 99%

Touch sensitivity in Caenorhabditis elegans

Bounoutas

Chalfie

2007

Pflugers Arch - Eur J Physiol

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“…In these species, the male nervous system is some 25% larger than that of the hermaphrodite and has extensive circuitry not found in the other sex (Sulston and Horvitz, 1977;Sulston et al, 1980;Sternberg and Horvitz, 1982). In C. elegans, all the neurons in both sexes are known, together with their lineal relationships to one another and to embryonic progenitor cells (Sulston and Horvitz, 1977;Sulston et al, 1980Sulston et al, , 1983. In the 302-neuron nervous system of the adult hermaphrodite, connectivity among the neurons has been established from electron micrographs of serial thin sections (White et al, 1986).…”

Section: Elegansmentioning

confidence: 99%

“…In the 302-neuron nervous system of the adult hermaphrodite, connectivity among the neurons has been established from electron micrographs of serial thin sections (White et al, 1986). The male nervous system contains almost all of the same neurons as that of the hermaphrodite plus an additional set of 79 neurons and 36 neuronal support cells (Sulston et al, 1980). Connectivity in the male nervous system remains to be determined.…”

Section: Elegansmentioning

confidence: 99%

“…Circuitry involving most of the male-specific neurons is present in a large ventral ganglion just anterior of the cloaca, the preanal ganglion (Sulston et al, 1980) (Fig. 1).…”

Section: Elegansmentioning

confidence: 99%

“…Because it is possible to observe cellular-level development of the nervous system in C. elegans, this class of genes can be clearly identified. Most of the male-specific nervous system arises postembryonically from the divisions of a handful of blast cells lying in three epidermal tissues in the tail, the rectal epithelium, the ventral epidermis, and the lateral epidermis (Sulston et al, 1980). The rectal epithelium generates the spicules and their associated neurons, neurons of the postcloacal sensilla, and interneurons in the preanal ganglion; the ventral epidermis generates the hook and its associated sensillae; and the lateral epidermis generates the rays.…”

Section: Developmental Genes Required For Male Sexual Behaviormentioning

confidence: 99%

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Genetic basis of male sexual behavior

Emmons

Lipton

2002

J. Neurobiol.

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Male sexual behavior is increasingly the focus of genetic study in a variety of animals. Genetic analysis in the soil roundworm Caenorhabditis elegans and the fruit fly Drosophila melanogaster has lead to identification of genes and circuits that govern behaviors ranging from motivation and mate-searching to courtship and copulation. Some worm and fly genes have counterparts with related functions in higher animals and many more such correspondences can be expected. Analysis of mutations in mammals can potentially leadto insights into such issues as monogamous versus promiscuous sexual behavior and sexual orientation. Genetic analysis of sexual behavior has implications for understanding how the nervous system generates and controls a complex behavior. It can also help us to gain an appreciation of how behavior is encoded by genes and their regulatory sequences.

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Neuronal localization of serotonin inAscaris suum

et al. 1996

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We have used immunocytochemical techniques to investigate the distribution of serotonin-like immunoreactivity in the nematode Ascaris suum. Antisera raised against serotonin (5-hydroxytryptamine, 5-HT) conjugated to bovine serum albumin (BSA) labelled a pair of neurons in the pharynx of both sexes and five cells in the ventral cord of the male tail. The labelling was blocked by 5-HT or by 5-HT conjugated to BSA. The 5-HT-immunoreactive cells in the pharynx resemble neurosecretory cells and are probably homologous to the neurosecretory motor neurons (NSM) in Caenorhabditis elegans; the cells in the male tail appear to be motor neurons that are homologous to CP neurons in C. elegans. Other cells that stain with 5-HT antisera have been observed in C. elegans but are not seen in Ascaris.

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The Caenorhabditis elegans male: Postembryonic development of nongonadal structures

Cited by 537 publications

References 10 publications

Touch sensitivity in Caenorhabditis elegans

Touch sensitivity in Caenorhabditis elegans

Genetic basis of male sexual behavior

Neuronal localization of serotonin inAscaris suum

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