The C718T polymorphism in the 3′-untranslated region of glutathione peroxidase-4 gene is a predictor of cerebral stroke in patients with essential hypertension

Abstract

In the present study we have investigated the association of three single nucleotide polymorphisms in glutathione peroxidase (GPx) genes GPX1 rs1050450 (P198L), GPX3 rs2070593 (G930A) and GPX4 rs713041 (T718C) with the risk of cerebral stroke (CS) in patients with essential hypertension (EH). A total of 667 unrelated EH patients of Russian origin, including 306 hypertensives (the EH-CS group) who suffered from CS and 361 people (the EH-CS group) who did not have cerebrovascular accidents, were enrolled in the study. The variant allele 718C of the GPX4 gene was found to be significantly associated with an increased risk of CS in hypertensive patients (odds ratio (OR) 1.53, 95% confidence interval (CI) 1.23-1.90, P adj ¼0.0003). The prevalence of the 718TC and 718CC genotypes of the GPX4 gene was higher in the EH-CS group than the EH-alone group (OR¼2.12, 95%CI 1.42-3.16, P adj ¼0.0018). The association of the variant GPX4 genotypes with the increased risk of CS in hypertensives remained statistically significant after adjusting for confounding variables such as sex, body mass index (BMI), blood pressure and antihypertensive medication use (OR¼2.18, 95%CI 1.46-3.27, P¼0.0015). Multiple logistic regression analysis did not reveal any interaction between various combinations of GPX1, GPX3 and GPX4 genotypes regarding the risk of CS in patients with EH. The study demonstrated for the first time that the C718T polymorphism in the 3¢-untranslated region of the GPX4 gene could be considered as a genetic marker of susceptibility to CS in patients with EH.

A case–control study of selenoprotein genes polymorphisms and autoimmune thyroid diseases in a Chinese population

“…GPx4 rs713041 polymorphisms could modulate the synthesis and expression of GPx4 by altering the selenocysteine insertion [27, 28]. GPx4 rs713041 were found to be associated with breast cancer mortality, the risk of colorectal cancer and cerebral stroke [23, 29, 30]. GPx4 rs2074451 variant was also found to be associated with breast cancer survival [24].…”

A comprehensive study revealed SNP–SNP interactions and a sex-dependent relationship between polymorphisms of the CYP2J2 gene and hypertension risk

“…The discovery sample, including 1558 unrelated individuals (913 patients with EH and 645 age-and sex-matched healthy controls), was recruited from the Cardiology Clinics of Kursk Regional Clinical Hospital and the Neurology Clinics of Kursk Emergency Medicine Hospital. These study patients were enrolled during two study periods: the first period was between 2003 and 2006 and the second period was between 2007 and 2012 [34][35][36][37]. The control group included blood donors, healthy volunteers and hospital-based patients (all subjects were recruited from the surgical, traumatic, and infectious divisions of Kursk hos pitals) with normal blood pressure and without cardiovas cular or other chronic diseases.…”

“…The control group included blood donors, healthy volunteers and hospital-based patients (all subjects were recruited from the surgical, traumatic, and infectious divisions of Kursk hos pitals) with normal blood pressure and without cardiovas cular or other chronic diseases. The control group was recruited over the same periods of time [34][35][36][37][38]. To ensure an ethnically homogeneous population, only Russian resi dents living in Central Russia for at least two generations have been included in the study.…”

Investigation of the association between the HindIII polymorphism of the LPL gene and the Taq1b polymorphism of the CETP gene with the risk of atherothrombotic stroke in the dwellers of Central Russia

“…биологии, медицинской ге-нетики и экологии; 305041 Курск, ул. К. Маркса, 3; тел./факс: +7(471)258-8147; е-mail: olga.bushueva@inbox.ru ИИ, однако во многих случаях результаты исследований оказались противоречивыми [1][2][3][4][5][6][7][8][9]. Известно, что основ-ной причиной ИИ служит атеросклероз мозговых сосу-дов, в развитии которого ведущую роль играют наруше-ния липидного обмена.…”

“…Всего обследованы 249 пациентов с АИ, находившихся на стационарном лечении в неврологических отделениях Курской областной клинической больницы и город-ской больницы скорой медицинской помощи Курска в период с 2007 по 2010 г. [8][9]. Кроме того, обследованы 168 пациентов, проходивших лечение в Региональном сосудистом центре Кур-ской областной клинической больницы в 2012-2013 гг.…”