THE BURNING OF CO TO CO<sub>2</sub> BY ISOLATED TISSUES AS SHOWN BY THE USE OF RADIOACTIVE CARBON

Clark, Robert T.; Stannard, J. N.; Fenn, Wallace O.

doi:10.1152/ajplegacy.1950.161.1.40

Cited by 21 publications

(10 citation statements)

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“…This stimulation occurs in the dark or diffuse daylight and, as shown by Schmitt and Scott (1934), is increased by strong illumination. Fenn and Cobb (1932b) adduced evidence to show that the CO was oxidized to CO 2 and this has been further substantiated by Clark, Stannard and Fenn (1950) by the use of isotopically labelled CO. The latter investigators (1949) also reported such oxidation of CO by the intact animal (turtles and mice).…”

Section: Discussionmentioning

confidence: 93%

The Oxidative Metabolism of Eggs of Urechis Caupo

Rothschild¹,

Tyler²

1958

The Biological Bulletin

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Section: Discussionmentioning

confidence: 93%

The Oxidative Metabolism of Eggs of Urechis Caupo

Rothschild¹,

Tyler²

1958

The Biological Bulletin

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“…If this does occur, then the measured \Tco underestimates the true value and actually represents only "net" CO production. It has been amply confirmed that CO can be oxidized to CO2 in tissues in vitro (18,19), and in intact turtles and mice (20) when high concentrations of CO are present. In man, however, evidence is lacking that this can occur in significant amounts under physiological conditions.…”

Section: Discussionmentioning

confidence: 99%

Endogenous Carbon Monoxide Production in Man*

Coburn¹,

Blakemore²,

Forster³

1963

J. Clin. Invest.

232

131

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Since the late 19th century, carbon (CO) has been known to be present in of normal man and animals. The origin in blood, however, has not been entirely Although it might be assumed that all CO is absorbed from the environment, thors have thought that some, at least, endogenously. The difficulties in de whether blood CO arises endogenously oi been the lack of knowledge of the vari govern CO uptake and loss from the uncertainty of the degree of exogenc sure to CO, and the lack of accurate ar CO analytical methods.In 1894, Grehant (1) monoxide nous and endogenous origin of the gas. In rethe blood cent years, the endogenous formation of CO has of the gas been studied by Sjdstrand and his associates in explained. Sweden (6, 7). the blood These investigators, however, have not measmany au-ured the actual rate at which CO is formed. The is formed instrument 1 used in their experiments to analyzẽ termining CO actually measures the temperature increase r not have during its catalytic combustion. In our hands, it is ables that relatively nonspecific for CO, and it seemed posbody, the sible that some of their findings might have been )us expo-produced by the presence of gases other than CO. id specific Their conclusion that CO is produced in normal man (7) depended on the demonstration of )rmal dog higher CO concentrations in expired than in in-)mbustible spired air. This, however, could be possible in the >), Leoper absence of endogenous CO formation if an unbloed (5) steady state existed between blood CO hemogloin human bin (COHb) and inspired CO concentration; this an exoge-could have occurred if their subjects had been exposed to higher CO concentrations in the environment as long as several hours before the experiments. We have developed an analytical method that appears to be specific for CO and can detect the addition of 0.3 ml of CO to the total adult C 0 2 human CO store by the analysis of a 2-ml blood A B SO R B E R sample (8). We have overcome some of the other criticisms by measuring the increase in blood COHb during extended periods of rebreathing in a closed system. METHODS

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“…The use of carbon monoxide to tag red blood cells yields values for blood volume that, on the average, agree with those obtained with T1824 (137,138). Evidence has, however, been adduced that carbon monoxide may be oxidized to some extent in the body (139,140,141).…”

Section: Volumes Of Body Fluidsmentioning

confidence: 99%

Laboratory Aids to Diagnosis and Therapy

Peters¹

1951

Annu. Rev. Med.

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THE BURNING OF CO TO CO₂ BY ISOLATED TISSUES AS SHOWN BY THE USE OF RADIOACTIVE CARBON

Cited by 21 publications

References 0 publications

The Oxidative Metabolism of Eggs of Urechis Caupo

The Oxidative Metabolism of Eggs of Urechis Caupo

Endogenous Carbon Monoxide Production in Man*

Laboratory Aids to Diagnosis and Therapy

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THE BURNING OF CO TO CO2 BY ISOLATED TISSUES AS SHOWN BY THE USE OF RADIOACTIVE CARBON

Cited by 21 publications

References 0 publications

The Oxidative Metabolism of Eggs of Urechis Caupo

The Oxidative Metabolism of Eggs of Urechis Caupo

Endogenous Carbon Monoxide Production in Man*

Laboratory Aids to Diagnosis and Therapy

Contact Info

Product

Resources

About

THE BURNING OF CO TO CO₂ BY ISOLATED TISSUES AS SHOWN BY THE USE OF RADIOACTIVE CARBON