The burden of zoonoses in Paraguay: A systematic review

Noguera, Liz; Rüegg, Simon R.; Torgerson, Paul R.

doi:10.1371/journal.pntd.0009909

Cited by 11 publications

(14 citation statements)

References 47 publications

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“…Studies that include human and animal data for zoonoses are relatively new (published in the last 20 years, S2 Fig) . We observed an increased number of reports on the dual burden of diseases over the years. Up to date, only three studies have reported zDALYs: on cystic echinococcosis in Morocco [13], 25 zoonoses in Paraguay [11], Taenia solium in Lao PDR [12]. We excluded them from our synthesis since they already contain zDALY values.…”

Section: Discussionmentioning

confidence: 99%

“…The excluded studies with zDALYs were neurocysticercosis in Northern Lao PDR with 3497 zDALYs, cystic echinococcosis in Morocco 18,330 (95% CI 17,775-19,074), and PLOS NEGLECTED TROPICAL DISEASES (bacterial, parasitic, viral, fungal) zoonoses in Paraguay with zDALYs of 62,178 (95% CI 48,696-77,188) (SI 3) [11][12][13]. The percentages attributable to animal burden were 0.4% for Northern Lao PDR, 99% for Morocco, and 69% for Paraguay.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the availability of data on the zoonosis burden in humans and animals regarding monetary and societal costs separately, only a few studies have estimated the dual burden in animals and humans [11][12][13]. We conducted a systematic review of the literature focusing on socio-economic burden of zoonoses worldwide and estimated the zDALYs of such studies.…”

Section: Introductionmentioning

confidence: 99%

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The dual burden of animal and human zoonoses: A systematic review

et al. 2022

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Background Zoonoses can cause a substantial burden on both human and animal health. Globally, estimates of the dual (human and animal) burden of zoonoses are scarce. Therefore, this study aims to quantify the dual burden of zoonoses using a comparable metric, “zoonosis Disability Adjusted Life Years” (zDALY). Methodology We systematically reviewed studies that quantify in the same article zoonoses in animals, through monetary losses, and in humans in terms of Disability Adjusted Life Years (DALYs). We searched EMBASE, Web of Science, Scopus, PubMed, and Google Scholar. We excluded articles that did not provide the data to estimate the zDALY or those for which full text was not available. This study was registered at PROSPERO, CRD42022313081. Principal findings/Significance We identified 512 potentially eligible records. After deduplication and screening of the title and abstract, 23 records were assessed for full-text review. Fourteen studies were included in this systematic review. The data contains estimates from 10 countries, a study at continental level (Asia and Africa), and 2 studies on a global scale. Rabies was the most frequently reported zoonosis where zDALYs were calculated, based on the following included studies: for Kazakhstan 457 (95% CI 342–597), Viet Nam 5316 (95% CI 4382–6244), Asia 1,145,287 (90% CI 388,592–1,902,310), Africa 837,158 (90% CI 283,087–1,388,963), and worldwide rabies 5,920,014 (95% CI 1,547,860–10,290,815). This was followed by echinococcosis, the zDALYs in Peru were 2238 (95% CI 1931–2546), in China 1490 (95% CI 1442–1537), and worldwide cystic echinococcosis 5,935,463 (95% CI 4,497,316–7,377,636). Then, the zDALYs on cysticercosis for Mozambique were 2075 (95% CI 1476–2809), Cameroon 59,540 (95% CR 16,896–101,803), and Tanzania 34,455 (95% CI 12,993–76,193). Brucellosis in Kazakhstan were 2443 zDALYs (95% CI 2391–2496), and brucellosis and anthrax in Turkey 3538 zDALYs (95% CI 2567–6706). Finally, zDALYs on leptospirosis in New Zealand were 196, and Q fever in Netherlands 2843 (95% CI 1071–4603). The animal burden was superior to the human burden in the following studies: worldwide cystic echinococcosis (83%), brucellosis in Kazakhstan (71%), leptospirosis in New Zealand (91%), and brucellosis, and anthrax in Turkey (52%). Countries priorities on zoonoses can change if animal populations are taken into consideration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The dual burden of animal and human zoonoses: A systematic review

et al. 2022

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“…Estimation of the zDALYs will provide a good basis for underestimating the dual burden of zoonoses and address the knowledge gap in this area. We presume that only a few studies have calculated zDALYs for zoonotic diseases (10,11).…”

Section: Discussionmentioning

confidence: 99%

Protocol of the Dual Burden of Animal and Human Zoonoses: A Systematic Review

Noguera¹,

Charypkhan²,

Rüegg³

et al. 2022

Preprint

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Background: When we talk about zoonoses, it is undeniable that we have a human and animal population that has been isolated in studies over time. Besides human and animal health, zoonoses also impact the economy and society. Therefore, the integration of the analysis in this area is essential to optimize resources in public health decisions. We have new challenges in public health that we need to overcome in a more comprehensive method such as One Health. For better measures in public health, the dual burden of zoonoses seems a logical way to determine the integral impact of such diseases in society and thus take better measures to prevent and reduce the impact of these diseases. Methods: We follow the guidelines for “Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). We search human and animal zoonoses on Embase, Ovid Medline, Scopus, Web of Science, and Google Scholar, from an unrestricted period until November 2021. For the search, we consider the Disability Adjusted Life Years (DALYs) for the human zoonotic burden and the animal zoonotic burden in monetary terms. A librarian collaborates to optimize the search string for the databases, and two reviewers screen eligible articles (first by title, then by abstracts, and finally, by full-text assessment.) For the analysis, we aim to convert the burden of zoonoses of all selected studies into the zoonotic Disability Adjusted Life Years (zDALYs) – including the human and animal components. Discussion: The study results will provide information on published studies that have accounted for the dual burden of zoonoses (both human and animal health aspects.) In addition, the synthesis of the available literature will address the knowledge gap in this area in order to know to what extent it is possible to convert the burden of human zoonoses to the animal burden of zoonoses and integrate them into a more comprehensive approach (dual burden of zoonoses.)

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“…These include an additional component called animal loss equivalents, which converts the expected livestock production and local per capita income losses to the equivalent number of human YLD. Nevertheless, this metric has been rarely used in cost-effectiveness analyses of zoonotic diseases (44,45), and only once for schistosomiasis (46).…”

Section: Pillar Ii: Economicsmentioning

confidence: 99%

Public Health Policy Pillars for the Sustainable Elimination of Zoonotic Schistosomiasis

Janoušková¹,

Clark²,

Kajero³

et al. 2022

Preprint

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Schistosomiasis is a parasitic disease acquired through contact with contaminated freshwater. The definitive hosts are terrestrial mammals, including humans, with some Schistosoma species crossing the animal-human boundary through zoonotic transmission. An estimated 12 million people live at risk of zoonotic schistosomiasis caused by Schistosoma japonicum and Schistosoma mekongi, largely in the World Health Organization’s Western Pacific Region and in Indonesia. Mathematical models have played a vital role in our understanding of the biology, transmission, and impact of intervention strategies, however, these have mostly focused on non-zoonotic Schistosoma species. Whilst these non-zoonotic-based models capture some aspects of zoonotic schistosomiasis transmission dynamics, the commonly-used frameworks are yet to adequately capture the complex epi-ecology of multi-host zoonotic transmission. However, overcoming these knowledge gaps goes beyond transmission dynamics modelling. To improve model utility and enhance zoonotic schistosomiasis control programmes, we highlight three pillars that we believe are vital to sustainable interventions at the implementation (community) and policy-level, and discuss the pillars in the context of a One-Health approach, recognising the interconnection between humans, animals and their shared environment. These pillars are: (1) human and animal epi-ecological understanding; (2) economic considerations (such as treatment costs and animal losses); and (3) sociological understanding, including inter- and intra-human and animal interactions.

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The burden of zoonoses in Paraguay: A systematic review

Cited by 11 publications

References 47 publications

The dual burden of animal and human zoonoses: A systematic review

The dual burden of animal and human zoonoses: A systematic review

Protocol of the Dual Burden of Animal and Human Zoonoses: A Systematic Review

Public Health Policy Pillars for the Sustainable Elimination of Zoonotic Schistosomiasis

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