The burden of serious fungal diseases in Russia

Климко, Н Н; Kozlova, Y I; Хостелиди, С Н; Шадривова, О В; Borzova, Yu. V.; Burygina, E V; Vasilieva, Nadezhda V.; Denning, David W.

doi:10.1111/myc.12388

Cited by 43 publications

(77 citation statements)

References 21 publications

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“…Such a study would also reveal trends as we suspect that the rate of CPA will be falling slowly as TB cases fall, although the high number of COPD and asthma cases may reverse this (unproven) trend. The annual incidence of opportunistic fungal infections in HIV-positive patients is low, having a similar or even a reduced value compared with other EU countries [25][26]. This fact is due to the successful implementation of the National HIV/AIDS Programme allowing ARV for the majority of cases.…”

Section: Discussionmentioning

confidence: 91%

“…Likewise the high rate of lung cancer related to smoking (especially in men) may be contributing to high rates of invasive aspergillosis. The rate of candidaemia was estimated to 5 cases per 100,000 inhabitants, corresponding to a low average for Europe (3.0-11.4/100,000), higher than Norway and Finland, but significantly lower than Spain, Denmark, and Russia [25,27]. However this population based rate needs validation with a registry (as in the UK and Denmark) or a multicentre epidemiological study.…”

Section: Discussionmentioning

confidence: 99%

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Burden of Serious Fungal Diseases in Romania

Mareș¹,

Vr²,

Denning³

2018

Preprint

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Abstract:Objective: To estimate for the first time the burden of fungal infections in Romania; Methods: Data derived from the World Health Organization (WHO), National Institute of Statistics, Romanian public health agencies and non-profit health organizations and published annual reports on local epidemiology were used in the present study. When no data was available, specific at-risk populations were used to calculate frequencies of serious fungal diseases, using previously published epidemiological parameters. All data refer to the year 2016; Results: The estimated number of serious fungal infections in Romanian population was 436,230 in 2016. Recurrent vulvovaginal candidiasis accounts for up to 80% of total cases (more than 350,000 women annually). Concerning the HIV related infections, among 14,349 infected persons, Pneumocystis pneumonia occurred in about 10% of late presenters (30 cases in 2016), while cryptococcal meningitis is rarely diagnosed (less than 20 cases). Annually, the total number of oesophageal candidiasis and oral thrush cases in HIV-positive patients may be as high as 1,229 and 3,066, respectively. In immunocompromised and cancer patient populations, the annual incidence of candidaemia is 295, and at least 458 invasive aspergillosis cases and 4 mucormycosis cases occur yearly. With 4,966 critical care beds and approximately 200,000 abdominal surgeries performed, the estimated annual incidence of candidaemia and Candida peritonitis is 689 and 344, respectively. The annual incidence of pulmonary tuberculosis is still high in Romania (12,747 cases). Thus, the prevalence of post-TB chronic pulmonary aspergillosis is estimated to be 8.98/100,000 (1,768 cases). The prevalence of chronic obstructive pulmonary disease (COPD) and asthma in adults is 6% and 6.5%, respectively. Therefore, allergic bronchopulmonary aspergillosis prevalence is estimated at 29,387 and severe asthma with fungal sensitisation at 38,731 cases annually. Conclusions: Not being on the list of reportable diseases, the number of patients presenting with severe mycoses in Romania can only be roughly estimated. Based on local reports and prevalence estimation, we consider that at least 2.23% of Romanians suffer a serious form of fungal disease.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Burden of Serious Fungal Diseases in Romania

Mareș¹,

Vr²,

Denning³

2018

Preprint

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“…Наиболее значимыми факторами риска для аспергиллезной нейроинфекции являются длительная и глубокая иммуносупрессия, иммунокомпрометация при использовании кортикостероидов и цитостатиков. Поражение ЦНС инфекцией грибковой этиологии сопряжено с высоким уровнем летальности: 90-100 % у пациентов с иммуносупрессией и 40-80 % у иммунокомпрометированных больных [2,3]. Российский журнал ДЕТСКОЙ ГЕМАТОЛОГИИ и ОНКОЛОГИИ R u s s i a n J o u r n a l o f P e d i a t r i c H e m a t o l o g y а n d O n c o l o g y рует работу фагоцитов и увеличивает резистентность конидий к опсонизации.…”

Section: Introductionunclassified

Case of successful treatment of neuroaspergillosis in oncological patient

Изможерова

Кулева

Иванова

et al. 2019

Ross. ž. det. gematol. onkol.

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Invasive mycoses caused by fungi of the genus Aspergillus, today remain an urgent clinical problem in oncological patients. In 10–20 % of patients with primary by aspergilloma can be detected in the Central nervous system. The article describes a case of neuroaspergillosis in an immunocompromised patient with choroid carcinoma of the right parietal-occipital lobe of the brain. Correct interpretation of risk factors, clinical symptoms and imaging techniques, early diagnosis with verification the pathological process, the use of fungistatic and fungicidal drugs allowed to avoid the negative consequences of fungal neuroinfection.

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“…Это связано не только с совершенствованием методов диагностики микозов, но и с более «агрессивными» схемами цито-статической терапии, широким использованием трансплантации гемопоэтических стволовых клеток и органов как «терапии спасения» [1]. Кроме того, инвазивные микозы отличаются агрессивным течени-ем и достаточно высоким уровнем летальности.…”

Section: Introductionunclassified