The Burden of Disease in Pediatric Non-Cystic Fibrosis Bronchiectasis

Respiratory viruses in exacerbations of non-cystic fibrosis bronchiectasis in children

“…Pulmonary exacerbations increase morbidity,3 and are associated with progressive deterioration in lung function4 and poor quality of life,5 but little research data are available. Indeed, though clinically suspected, there are no published prospective data on viral triggers of pulmonary exacerbations of non-CF bronchiectasis.…”

Respiratory Exacerbations in Indigenous Children From Two Countries With Non-Cystic Fibrosis Chronic Suppurative Lung Disease/Bronchiectasis

“…8,9 AREs in people with bronchiectasis are associated with hospitalizations, declining lung function, and reduced quality of life. 10 Th ey have also been used as outcome measures in therapeutic trials in adults 11 and children 12 with bronchiectasis. Th us, understanding factors associated with recurrent and severe AREs is important.…”

An acute cough-specific quality-of-life questionnaire for children: Development and validation

“…A chronic cough-specific QoL measure 11,12 has been shown to be a useful evaluation tool in clinical research studies (including randomized controlled trials) in children with chronic cough-dominated illnesses. [27][28][29] Although there are other scales for measuring acute respiratory illness effects, such as the validated Canadian Acute Respiratory Illness and Flu Scale, 14 this instrument is not specific to acute cough and has a large number of daily reported items not specifically relating to cough. An adult-based acute cough QoL tool 17 exists, but because there are significant differences between adults and children, adult-specific QoL measures are not directly transferrable to pediatric research.…”