Respiratory Exacerbations in Indigenous Children From Two Countries With Non-Cystic Fibrosis Chronic Suppurative Lung Disease/Bronchiectasis

Redding, Gregory J.; Singleton, Rosalyn; Valery, Patricia C.; Williams, Hayley; Grimwood, Keith; Morris, Peter S.; Torzillo, Paul J.; McCallum, Gabrielle B.; Chikoyak, Lori; Holman, Robert C.; Chang, Anne B.

doi:10.1378/chest.14-0126

Cited by 40 publications

(38 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nevertheless, chronic cough is a common problem in populations in LMICs in which HAP exposures are high and the underlying causative factors and pathology of chronic cough in these settings have not been characterised because CT scanning and epidemiological studies are not available. Bronchiectasis, or a syndrome that could perhaps more pragmatically be described as complex airways disease, which overlaps with other diagnoses such as chronic bronchitis, is a probable contributor to this burden of chronic cough, as has been shown in indigenous children in developed countries 168,169. This disorder is likely to be the result of many respiratory insults across the lifespan including in-utero and early life malnutrition, predisposition to and repeated episodes of acute lower respiratory tract infections, poor access to prompt effective treatment for ALRI, HIV infection, and complications after pulmonary tuberculosis.…”

Section: Obstructive Lung Diseasementioning

confidence: 99%

Respiratory risks from household air pollution in low and middle income countries

Gordon¹,

Bruce²,

Grigg³

et al. 2014

The Lancet Respiratory Medicine

757

592

View full text Add to dashboard Cite

A third of the world’s population uses solid fuel derived from plant material (biomass) or coal for cooking, heating, or lighting. These fuels are smoky, often used in an open fire or simple stove with incomplete combustion, and result in a large amount of household air pollution when smoke is poorly vented. Air pollution is the biggest environmental cause of death worldwide, with household air pollution accounting for about 3·5–4 million deaths every year. Women and children living in severe poverty have the greatest exposures to household air pollution. In this Commission, we review evidence for the association between household air pollution and respiratory infections, respiratory tract cancers, and chronic lung diseases. Respiratory infections (comprising both upper and lower respiratory tract infections with viruses, bacteria, and mycobacteria) have all been associated with exposure to household air pollution. Respiratory tract cancers, including both nasopharyngeal cancer and lung cancer, are strongly associated with pollution from coal burning and further data are needed about other solid fuels. Chronic lung diseases, including chronic obstructive pulmonary disease and bronchiectasis in women, are associated with solid fuel use for cooking, and the damaging effects of exposure to household air pollution in early life on lung development are yet to be fully described. We also review appropriate ways to measure exposure to household air pollution, as well as study design issues and potential effective interventions to prevent these disease burdens. Measurement of household air pollution needs individual, rather than fixed in place, monitoring because exposure varies by age, gender, location, and household role. Women and children are particularly susceptible to the toxic effects of pollution and are exposed to the highest concentrations. Interventions should target these high-risk groups and be of sufficient quality to make the air clean. To make clean energy available to all people is the long-term goal, with an intermediate solution being to make available energy that is clean enough to have a health impact.

show abstract

Section: Obstructive Lung Diseasementioning

confidence: 99%

Respiratory risks from household air pollution in low and middle income countries

Gordon¹,

Bruce²,

Grigg³

et al. 2014

The Lancet Respiratory Medicine

757

592

View full text Add to dashboard Cite

show abstract

“…The principles of management for non-CF bronchiectasis are regular sputum clearance exercises and early, aggressive treatment of exacerbations, 7 in addition to investigation for an underlying cause at diagnosis. 10,11 Guidelines recommend that these exacerbations are treated with a 10-to 14-day course of antibiotics and, when required, hospital admission of ≥7 days for intensive therapy. 9 Infective exacerbations of bronchiectasis cause significant morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Bronchiectasis in the Kimberley region of Western Australia

Barton

Scott

Maguire

2018

Australian J Rural Health

View full text Add to dashboard Cite

show abstract

Section: Etiologymentioning

confidence: 99%

“…A study of 93 Indigenous children from Alaska and Australia with CSLD or bronchiectasis (42) reported 74% of children experienced >2 exacerbations over a 3-year period. In this study, the factors associated with recurrent episodes were young age (<3 years), hospitalization for an acute exacerbation in the first-year of life, and pneumonia or hospitalization for an acute exacerbation in the year preceding enrollment (42). Exacerbations are also more frequent in severe bronchiectasis, and one study of 111 children reported that intensive medical intervention reduced the annual exacerbation rate by 56%; however, children still experienced a mean of 2.9 episodes per year (43).…”

Section: Etiologymentioning

confidence: 99%

The Likelihood of Preventing Respiratory Exacerbations in Children and Adolescents with either Chronic Suppurative Lung Disease or Bronchiectasis

O’Grady

Grimwood

2017

Front. Pediatr.

Self Cite

View full text Add to dashboard Cite

Chronic suppurative lung disease (CSLD) and bronchiectasis in children and adolescents are important causes of respiratory morbidity and reduced quality of life (QoL), also leading to subsequent premature death during adulthood. Acute respiratory exacerbations in pediatric CSLD and bronchiectasis are important markers of disease control clinically, given that they impact upon QoL and increase health-care-associated costs and can adversely affect future lung functioning. Preventing exacerbations in this population is, therefore, likely to have significant individual, familial, societal, and health-sector benefits. In this review, we focus on therapeutic interventions, such as drugs (antibiotics, mucolytics, hyperosmolar agents, bronchodilators, corticosteroids, non-steroidal anti-inflammatory agents), vaccines and physiotherapy, and care-planning, such as post-hospitalization management and health promotion strategies, including exercise, diet, and reducing exposure to environmental toxicants. The review identified a conspicuous lack of moderate or high-quality evidence for preventing respiratory exacerbations in children and adolescents with CSLD or bronchiectasis. Given the short- and long-term impact of exacerbations upon individuals, their families, and society as a whole, large studies addressing interventions at the primary and tertiary prevention phases are required. This research must include children and adolescents in both developing and developed countries and address long-term health outcomes.

show abstract

Respiratory Exacerbations in Indigenous Children From Two Countries With Non-Cystic Fibrosis Chronic Suppurative Lung Disease/Bronchiectasis

Cited by 40 publications

References 27 publications

Respiratory risks from household air pollution in low and middle income countries

Respiratory risks from household air pollution in low and middle income countries

Bronchiectasis in the Kimberley region of Western Australia

The Likelihood of Preventing Respiratory Exacerbations in Children and Adolescents with either Chronic Suppurative Lung Disease or Bronchiectasis

Contact Info

Product

Resources

About