The burden of disease and injury in Iran 2003

Naghavi, Mohsen; Abolhassani, Farid; Pourmalek, Farshad; Moradi‐Lakeh, Maziar; Jafari, Nahid; Vaseghi, Sanaz; Hezaveh, Niloufar Mahdavi; Kazemeini, Hossein

doi:10.1186/1478-7954-7-9

Cited by 258 publications

(264 citation statements)

References 8 publications

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“…4 DALYs lost per 1000 of the population in Iran. 3 Fifty-three percent of the total numbers of DALYs in Iran were in male patients, and 47% of DALYs were in female patients. 3 As expected, this study showed almost twice higher burden of SCI in male patients.…”

Section: Discussionmentioning

confidence: 99%

“…However, according to a report from Iran in 2003, among disease groups, injuries has the highest burden of disease (DALY) which includes 28% of DALYF36.5% in male and 18% in female patients; and the first cause of years of life lost because of premature mortality (YLL). 3 Spinal trauma complicated by injury to the spinal cord is a devastating event on a personal and family level, as well as a tremendous financial burden to society because of its attendant morbidity, expense and prolonged treatment requirements. 4 Among all causes of injury-related morbidities, spinal cord injury (SCI) has one of the highest burdens because of permanent disability.…”

Section: Introductionmentioning

confidence: 99%

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Burden of spinal cord injury in Tehran, Iran

et al. 2009

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Study Design: Investigation of burden of traumatic spinal cord injury (SCI) using disease modeling. Objectives: The present paper is intended to estimate the SCI burden for the year 2008. Setting: Tehran, capital of Iran. Methods: Epidemiological data needed to calculate Disability-Adjusted Life-Years (DALYs) for SCI, was estimated according to prevalence, duration and relative risk of mortality using DISMOD software. For DALY calculation, the years of life lost because of premature mortality (YLL) was added to the number of years lost because of disability (YLD). To calculate DALYs for SCI, first year DALY calculated separately and for the next years, the DALY was assessed for six different clinical presentations of traumatic SCI including quadriplegia, quadriparesis, paraplegia, paraparesis, hemiplegia and hemiparesis. Results: In first year following SCI, the DALY was 3772 years, which has 0.5 DALY per 1000 people and YLL/DALY was 89.3%. Following the first year, the DALY was 435 for quadriplegia, 163 for quadriparesis, 868 for paraplegia, 164 for paraparesis, 26 for hemiplegia and 14 for hemiparesis. The total YLL for traumatic SCI was 4077 years and total YLD was 1364 years (total YLL/DALY was 74.9%) and total DALY was 5441 years, (M/F ¼ 2.0), which has 0.7 DALY per 1000 people in Tehran in 2008. Conclusions: This study showed a high burden for SCI. Identifying the risk factors of SCI, and performing cost-effective preventive interventions for reducing burden of SCI is recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Burden of spinal cord injury in Tehran, Iran

et al. 2009

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“…Less than 1% of breast cancer cases arise before 25 years of age but after 30, the incidence increases significantly and also increases with advancing the age (Jemal et al, 2009). Although the peak age of the onset for breast cancer is between 6th and 7th decades of the life worldwide, in Iranian population it seems that it is between 40 and 60 years of age (Naghavi et al, 2009). Most of the breast cancer cases are sporadic, however, a significant proportion are due to inheritance of particular genetic factors including mutations in specific genes (Fry-Johnson and Rowley, 2010 and Pichert, 2005).…”

Section: Introductionmentioning

confidence: 99%

Analysis of CYP17, CYP19 and CYP1A1 Gene Polymorphisms in Iranian Women with Breast Cancer

Farzaneh¹,

Noghabaei²,

Barouti³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Breast cancer (BC) is the most common cancer and the second cause of mortality in women all around the world. It is caused by several factors including genetic determinants, so that both genetic susceptibility factors and environmental factors are involved in the etiology. Significance of genes functioning in steroid hormone synthesis and metabolism are well established in breast cancer susceptibility. In this study, 134 women with BC and 135 normal controls were analyzed for their genotypes for the polymorphisms, rs743572, rs10046 and rs4646903, resided in CYP17, CYP19 and CYP1A1 genes, respectively. Significant differences in distributions of allele and genotype frequencies were found for the rs10046 polymorphism in CYP19 (p-value=0.01, OR (CI 95%) =1.59 (1.1-2.3), p-value=0.04, OR (CI 95%) =1.7 (1.1-2.5) respectively). For rs743,572 and rs 4646903 polymorphisms, no significant associations were observed. A significant association was observed between the rs10046 polymorphism of the CYP19gene and breast cancer in Iranian patients. Due to inconsistent previous results, more studies in different populations with larger sample sizes are indicated.

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“…In 2003, natural disasters contributed hugely to the disability-adjusted life-years (DALY) lost in Iran, being the second most important cause among male Iranians of all ages and the third most important among female Iranians (Naghavi et al, 2009). In the many earthquake-prone areas of the country, earthquakes may often have dramatic impacts not only on the epidemiology of many diseases (including CL, especially if it is already endemic) but also on healthcare (if the health infrastructure is severely damaged).…”

Section: Post-earthquake Cutaneous Leishmaniasis In Iranmentioning

confidence: 99%