The burden of acute otitis media on the patient and the family

Greenberg, David; Bilenko, Natasha; Liss, Zvi; Shagan, Tomer; Zamir, Orly; Dagan, Ron

doi:10.1007/s00431-003-1260-5

Cited by 54 publications

(46 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The manual search and expert discussion yielded one extra article [28]. After applying the criteria for inclusion and exclusion, only 13 articles remained for inclusion [29,30,[35][36][37][38][39][40][41][42][43][44]. In addition, we included results regarding reliability and validity of the TAIQOL from our own work published in a thesis [45].…”

Section: Resultsmentioning

confidence: 99%

“…The setting of the studies varied, eight studies were part of a multi-centre trial [28,35,37,38,41,[43][44][45]. Most study-populations consisted of children with chronic or recurrent otitis media ( Table 2).…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…The definitions of chronic and recurrent OM regarding number of OM episodes and duration, however, varied considerably. Chronic OME was defined as middle ear effusion in one or both ears for 6 weeks [36] to 6 months [41], rAOM as three or more episodes in previous 6 months [36,38,43] or more than three [29,45] to five [42] episodes within last year. Age of the patients ranged from 0 to 13 years of age.…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Health-related quality of life in children with otitis media

Brouwer

Maillé

Rovers

et al. 2005

International Journal of Pediatric Otorhinolaryngology

View full text Add to dashboard Cite

SummaryBackground: Growing interest in health-related quality of life (HRQoL) in children with otitis media has brought the need to study the currently available HRQoL instruments with respect to their results and their applicability in clinical practice and research of otitis media. Objective: To review existing literature on health-related quality of life research in children with otitis media with respect to: (1) the measured impact of otitis media on HRQoL; and (2) the applicability of HRQoL instruments used in research and clinical practice based on their characteristics and contents.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of the Studiesmentioning

confidence: 99%

Section: Characteristics Of the Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Health-related quality of life in children with otitis media

Brouwer

Maillé

Rovers

et al. 2005

International Journal of Pediatric Otorhinolaryngology

View full text Add to dashboard Cite

show abstract

“…Estimates suggest that by 2 years of age, nearly a third of all children will have had more than three episodes of OM within 6 months or four episodes within 1 year (Poehling et al 2007). Recurrent and chronic forms of OM are associated with high economic and societal costs such as medical care costs, parental days lost from work, and loss of earnings (Greenberg et al 2003). Complications of COME/ROM include permanent hearing loss, tympanic membrane abnormalities (e.g., chronic ear drainage), other infections such as meningitis, and other sequelae (Daly et al 1998;Johnston et al 2004;Grevers 2010).…”

Section: Introductionmentioning

confidence: 99%

A Genome-Wide Association Study of Chronic Otitis Media with Effusion and Recurrent Otitis Media Identifies a Novel Susceptibility Locus on Chromosome 2

Allen

Chen

Weeks

et al. 2013

JARO

View full text Add to dashboard Cite

Chronic otitis media with effusion (COME) and recurrent otitis media (ROM) have been shown to be heritable, but candidate gene and linkage studies to date have been equivocal. Our aim was to identify genetic susceptibility factors using a genome-wide association study (GWAS). We genotyped 602 subjects from 143 families with 373 COME/ROM subjects using the Illumina Human CNV370-Duo DNA Bead Chip (324,748 SNPs). We carried out the GWAS scan and imputed SNPs at the regions with the most significant associations. Replication genotyping in an independent family-based sample was conducted for 53 SNPs: the 41 most significant SNPs with PG10 −4 and 12 imputed SNPs with PG10 −4 on chromosome 15 (near the strongest signal). We replicated the association of rs10497394 (GWAS discovery P= 1.30×10 −5 ) on chromosome 2 in the independent otitis media population (P=4.7×10 −5 ; meta-analysis P= 1.52×10 −8 ). Three additional SNPs had replication PvaluesG0.10. Two were on chromosome 15q26.1 including rs1110060, the strongest association with COME/ROM in the primary GWAS (P=3.4×10 −7 ) in KIF7 intron 7 (P=0.072), and rs10775247, a nonsynonymous SNP in TICRR exon 2 (P=0.075). The third SNP rs386057 was on chromosome 5 in TPPP intron 1 (P=0.045). We have performed the first GWAS of COME/ROM and have identified a SNP rs10497394 on chromosome 2 is significantly associated with COME/ROM susceptibility. This SNP is within a 537 kb intergenic region, bordered by CDCA7 and SP3. The genomic and functional significance of this newly identified locus in COME/ROM pathogenesis requires additional investigation.

show abstract

“…Em um recente estudo realizado em Valência, na Espanha, a incidência de OMA foi de 40.014 episódios/100.000 crianças menores de 5 anos (IC95% 39.700-40.300), com uso de antibióticos em 94,5% 14 . Em Israel, a média da duração (dias) de uso de antibióticos em crianças com OMA foi 9,0±5,6 15 . OMA é a infecção para a qual mais comumente se prescreve antibiótico, o que resulta em mais de 20 milhões de prescrições de antibióticos anualmente 16 .…”

Section: Introductionunclassified

Outpatient antibiotic therapy as a predisposing factor for bacterial resistance: a rational approach to airway infections

Nascimento‐Carvalho¹

2006

J Pediatr (Rio J)

View full text Add to dashboard Cite

Objectives: To present evidence-based recommendations for the use of antibiotics for the treatment of the most common acute respiratory infections (ARI) and the available information on the importance of this type of management.Sources: MEDLINE and LILACS databases, technical publications by international organizations, national and international directives. The search terms acute respiratory infection, otitis, sinusitis, tonsillitis, pneumonia, antibiotic, guidelines and bacterial resistance were used. Articles cited by the articles selected were analyzed for information of interest.Summary of the findings: Bacterial resistance has grown, to the extent that today it is recognized as a global public health problem. ARI are the most common cause of antibiotic usage within the community; yet a large proportion of these cases, compromising the upper (otitis, sinusitis, tonsillitis) or the lower airways (pneumonia), are the result of viral infections. Recommendations to rationalize the use of antibiotics in patients with ARI have the common objective of minimizing unnecessary antibiotic use, since antibiotic pressure is one of the factors triggering bacterial resistance.Conclusions: It is of great importance to differentiate among ARI patients those who will benefit from the use of antibiotics. The establishment of recommendations for the prescription of antibiotics is one strategy for minimizing the frequency of bacterial resistance.J Pediatr (Rio J). 2006;82(5 Suppl):S146-52: Antibiotics, bacterial resistance, otitis, sinusitis, tonsillitis, pneumonia. ResumoObjetivos: Apresentar as recomendações baseadas em evidência para uso de antibióticos no tratamento das infecções respiratórias agudas (IRA) mais freqüentes e as informações disponíveis sobre a importância desse tipo de conduta.Fontes dos dados: Bases de dados MEDLINE, LILACS, publicações técnicas de organizações internacionais, diretrizes nacionais e internacionais. Foram utilizados os unitermos acute respiratory infection, otitis, sinusitis, tonsillitis, pneumonia, antibiotic, guidelines, bacterial resistance. Artigos citados pelos artigos incluídos foram analisados quanto à apresentação de informação de interesse. Síntese dos dados:A resistência bacteriana tem crescido, sendo atualmente reconhecida como problema mundial de saúde pública. As IRA são a causa mais freqüente para uso de antibiótico na comunidade; grande parte desses casos, tanto nas vias aéreas superiores (otite, sinusite, faringoamidalite) como nas inferiores (pneumonia), são decorrente de infecção viral. As recomendações para racionalizar o uso de antibióticos nos pacientes com IRA têm como objetivo comum minimizar o uso desnecessário de antibióticos, visto que a pressão antibióti-ca é um dos fatores desencadeantes da resistência bacteriana.Conclusões: É de grande importância a distinção, entre os pacientes com IRA, daqueles que podem se beneficiar do uso de antibióticos. O uso das recomendações para a prescrição de antibióticos é uma estratégia para minimizar a freqüência de resistên...

show abstract

The burden of acute otitis media on the patient and the family

Abstract: Acute otitis media significantly reduces the quality of life of both child and parents, causes substantial use of medical services and significant loss of workdays.

Cited by 54 publications

References 16 publications

Health-related quality of life in children with otitis media

Health-related quality of life in children with otitis media

A Genome-Wide Association Study of Chronic Otitis Media with Effusion and Recurrent Otitis Media Identifies a Novel Susceptibility Locus on Chromosome 2

Outpatient antibiotic therapy as a predisposing factor for bacterial resistance: a rational approach to airway infections

Contact Info

Product

Resources

About