Background
People living with obesity have been among those most disproportionately impacted by the COVID-19 pandemic, highlighting the urgent need for increased provision of bariatric and metabolic surgery (BMS).
Objectives
To evaluate the possible clinical and economic benefits of BMS compared with non-surgical treatment options in the UK, considering the broader impact that COVID-19 has on people living with obesity.
Methods
A Markov model compared lifetime costs and outcomes of BMS and conventional treatment, from the UK perspective, amongst patients with BMI ≥40 kg/m
2
, or BMI ≥35 kg/m
2
with obesity-related comorbidities (Group A), or BMI ≥35 kg/m
2
with type 2 diabetes mellitus (T2DM; Group B). Inputs were sourced from clinical audit data and literature sources; direct and indirect costs were considered. Model outputs included costs and quality-adjusted life years (QALYs). Scenario analyses whereby patients experienced COVID-19 infection, BMS was delayed by five years, and BMS patients underwent endoscopy were conducted.
Results
In both groups, BMS was dominant versus conventional treatment, at a willingness-to-pay threshold of £25,000/QALY. When COVID-19 infections were considered, BMS remained dominant and, over 1,000 patients, prevented 117 deaths, 124 hospitalizations and 161 ICU admissions in Group A, and 64 deaths, 65 hospitalizations and 90 ICU admissions in Group B. Delaying BMS by 5 years resulted in higher costs and lower QALYs in both groups compared to not delaying treatment.
Conclusions
Increased provision of BMS would be expected to reduce COVID-19-related morbidity and mortality, as well as obesity-related comorbidities, ultimately reducing the clinical and economic burden of obesity.