The Breakdown of Embryonic (Chick) Cartilage and Bone Cultivated in the Presence of Complement-Sufficient Antiserum

Immunopathologic Studies in Relapsing Polychondritis

“…There is little insight into etiologic or pathophysiologic factors operative in this disease. A pathologic similarity has been shown to exist between polychondritis and the experimental papain (1) and hypervitaminosis-A (2) induced depletion of cartilaginous matrix as well as the model of complement-dependent cartilage lysis in vitro, mediated by anti-cell membrane antibody (3,4). However, the inflammation with predominant round cell infiltration and degeneration of chondrocytes observed in polychondritis are conspicuous differences.…”

Secretion and localization of cathepsin D in synovial tissues removed from rheumatoid and traumatized joints. An immunohistochemical study

“…The type A synovial lining cell of healthy joints resembles a macrophage (39). It is well established that the lining cells proliferate in rheumatoid arthritis: lining cells in pig synovium in culture infiltrate the underlying capsular tissue (40). Thus these macrophage-like cells may be derived from lining cells.…”

Experimental Gingivitis in the Albino Hamster

“…In addition to these effects, it has been demonstrated that lysosomal enzymes derived from inflammatory cells are capable of stimulating bone decalcification in vitro (Fell, Coombs, and Dingle, 1966}. It has been found that the number of PMN's in the gingival sulcus during the course of,experimental gingivitis in man is increased (Lee, Theilade, and Jensen, 1965) • Further, it has been postulated that the number of PMN's present may reflect the degree of inflammation in the_ gingival tissues (Klinkhamer, 1968).…”

“…These complexes are capable of initiating the complement 57 sequence, components of which can release chemical mediators of inflammation (Snyderman, 1973}. In addition, these anti-. gen-antibody complexes are directly chemotactic for polyn'torphonuclear·leukocytes (Boyden, 1962}, the products of which are known to contribute to tissue destruction (Fell, Coombs, andDingle, 1966, Cochrane, 1969). found.in negligible numbers in the normal oral flora of the albino hamster, the model used in this study (Keyes and Jor" dan, 1964): it has been demonstrated that this animal does not develop periodontal disease when subjected to a high carbohydrate diet, unlike the cream and ;golden strains which do develop the disease under similar circumstances {Keyes and .…”