Experimental Gingivitis in the Albino Hamster

Ranieri, John A.; Toto, Patrick D.; Gargiulo, Anthony W.

doi:10.1902/jop.1979.50.2.94

Cited by 2 publications

(1 citation statement)

References 39 publications

(50 reference statements)

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“…Nutnerous studies of experimental gingivitis and periodontitis have beeti reported in various animals. Among others, dogs {Egelberg 1965, Hannson, Lindhe & Branemark 1968, Schroeder & Lindhe 1980, cats (Nuki & Cooper 1972, Hock 1975, Seawright & Hdrlicka 1974, various strains of mice {Baer & White 1960, Rateitschak & Reimers 1969), hamsters (Ranieri, Toto & Garguilo 1979, Miller & Ripley 1975, rats (Leonard 1979, Zuckerman & Rosen 1975, Gtjpta & Shaw 1956a, and marmosets (Levy 1976) have been used to examine the development and pathology of gingivitis atid periodontitis. In most of these studies, gingivitis and/or periodontitis was induced b\ administratioti of certain diets or by JD c^ction of the animals with specific bacte-rial organisms.…”

Section: Introductionmentioning

confidence: 99%

Periodontal disease in the domestic cat

Reichart

Dürr

Triadan

et al. 1984

J of Periodontal Research

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One hundred and fifty teeth from 15 cats of an average age of 6.8 years were examined macroscopically, radiographically, and histologically. Clinical inspection revealed plaque and calculus deposits on the facial surfaces of maxillary and mandibular premolars and molars. Radiography showed horizontal and vertical loss of alveolar bone with irregular defects of the dental hard structures. Histologically, typical features of gingival and periodontal destruction were found and resorptive lacunae were seen at the cemento‐enamel junctions. In comparison with experimentally induced periodontitis in other animals, periodontal disease involving external root resorption seemed to occur spontaneously in the cat.

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Section: Introductionmentioning

confidence: 99%

Periodontal disease in the domestic cat

Reichart

Dürr

Triadan

et al. 1984

J of Periodontal Research

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Endotoxin-Induced Changes in Copper and Zinc Metabolism in the Syrian Hamster

Etzel

Swerdel

et al. 1982

The Journal of Nutrition

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The temporal response of zinc and copper metabolism to endotoxin administration was examined in Syrian hamsters over a 144-hour period. Serum copper was significantly elevated at 12, 24 and 72 hours after endotoxin, whereas serum zinc was reduced 4-48 hours after treatment. A brief elevation (8 hours) in liver copper concentration and a sustained (72 hours) increase in liver zinc concentration were also observed. The amount of zinc associated with liver metallothionein (MT) progressively increased with time, to a plateau by 24 hours and persisted at the elevated level until 72 hours after endotoxin treatment. In vitro translation of poly (A)+ RNA from liver polyribosomes showed that following endotoxin treatment MTmRNA activity was maximally elevated 6 hours after endotoxin administration and remained elevated 24 and 48 hours thereafter. Slab gel electrophoresis of serum proteins indicated changes in a stainable protein comigrating with purified ceruloplasmin after endotoxin administration. Pooled gingival tissue from endotoxin-treated hamsters demonstrated a consistently elevated copper content 12-144 hours after treatment. Endotoxin isolated from Bacteroides melaninogenicus was more effective in elevating gingival and serum copper and gingival zinc than Escherichia coli endotoxin. It was concluded that endotoxin administration elicits responses that result in enhanced metaollthionein mRNA activity. In addition, Cu and Zn concentrations in serum, liver and gingival tissue are influenced by different endotoxins to different degrees.

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Experimental Gingivitis in the Albino Hamster

Cited by 2 publications

References 39 publications

Periodontal disease in the domestic cat

Periodontal disease in the domestic cat

Endotoxin-Induced Changes in Copper and Zinc Metabolism in the Syrian Hamster

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