The Brazilian market of herbal medicinal products and the impacts of the new legislation on traditional medicines

Carvalho, Ana Cecília Bezerra; Lana, Túlio Nader; Perfeito, João Paulo Silvério; Silveira, Dâmaris

doi:10.1016/j.jep.2017.09.040

Cited by 58 publications

(52 citation statements)

References 3 publications

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“…Nevertheless, when these terms are combined with some pharmaceutical forms, few appeared, except in the Science Direct database, where for the pharmaceutical form "drug solution", this number was quite expressive compared to the others (27). This same graph illustrates that although the number of articles is high for Compositae with anti-inflammatory activity, the patents and products from species of this family does not follow that trend, which confirms the information of Carvalho et al [15] who mention that the market for biodiversity products is still very small.…”

Section: Metric Comparison Between Databasessupporting

confidence: 78%

“…However, according to Carvalho et al [15], although the market for natural products has expanded worldwide, Brazil does not seem to have participated in this expansion, since few products from Brazilian biodiversity have been licensed. Currently, one of the obstacles for finding phytotherapeutic products licensed in Brazil could be the complexity of the entire production chain for phytomedicines, as well as the transferring of basic research to the industrial scale and the communication between those involved in this process [16,17].…”

Section: Introductionmentioning

confidence: 99%

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Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential

Lopes

Oliveira²,

Viçosa³

et al. 2020

Planta Med

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Compositae is the largest family of flowering plants, with more than 1600 genera and 22 000 species. It has many economic uses in foods, cosmetics, and pharmaceutics. The literature reports its numerous medicinal benefits and recognized anti-inflammatory activity. Thus, this study evaluated the technological trends of anti-inflammatory activity of Compositae, based on the survey of scientific databases, articles, and patents, as well as the website of the Brazilian National Health Regulatory Agency (ANVISA), which is responsible for registering and controlling of healthcare and cosmetic products in the Brazil. The survey was conducted between 2008 and 2018, in the databases Science Direct, Lilacs, PubMed, and Web of Science (main collection), as well as the SciELO Citation Index. The patent survey was carried out on the basis of the Derwent Innovations Index, an important source for worldwide patent consultation, which covers 20 y of registered patents. Despite the numerous studies involving species of the Compositae family in different models of anti-inflammatory activity, there are few records of patents or products on the market from these species for that purpose. Some species have a traditional use and are present even in the Phytotherapic Summary of the Brazilian Pharmacopeia. This review confirms the therapeutic potential of Compositae for the development of anti-inflammatory drugs and reinforces the need to develop competencies and reduce technological bottlenecks to promote research and innovation in biodiversity products.

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Section: Metric Comparison Between Databasessupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential

Lopes

Oliveira²,

Viçosa³

et al. 2020

Planta Med

View full text Add to dashboard Cite

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“…Concerning its safety, when 1 was given to humans in different doses, it proved to be safe with no observed adverse effects [51]. We also considered a xanthone isolated from G. achachairu branches in our lab [41], identified as 1,3,5,6-tetrahydroxyxanthone [2]. Xanthones are a class of polyphenolic compounds that are widely found in plants and present beneficial cardiovascular effects.…”

Section: Isolated Compounds From Brazilian Medicinal Plants With Diurmentioning

confidence: 99%

Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects

et al. 2020

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Medicinal plants are used in traditional medicine to treat a wide range of ailments. The knowledge of them is handed down from generation to generation and is described in several pharmacopoeia and in the general literature. The immense biodiversity of the Brazilian flora, covering about 25% of all plant species worldwide, makes Brazil a huge potential source of medicinal plants. Indeed, many of these plant species are already used in the Brazilian ethnopharmacology for their probable effect to induce diuresis, to reduce fluid retention, and to treat cardiovascular and renal disorders. This review article describes and discusses the main native Brazilian medicinal plants (including some of their isolated compounds) used as diuretics. It also gives a comprehensive analysis of the most relevant scientific studies presented to date, as well as addressing a special topic with future prospects for plant species that have not yet been scientifically studied. In brief, several plants can be indicated for more detailed study, with a view to obtain scientific subsidies for a new and effective diuretic medicine in the future. These include Bauhinia forficata, Leandra dasytricha, and Tropaeolum majus. Other species have reputed medicinal properties but lack experimental assays to demonstrate their pharmacological effects (e.g., Mikania hirsutissima, Phyllanthus niruri, and Tagetes minuta). Several active principles are indicated as responsible for the diuretic effects of the plants studied, with emphasis on phenolic compounds as flavonoids, phenolic acids, and xanthones. These results should encourage more detailed preclinical, clinical, and phytochemical investigations on Brazilian plants in the future.

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“…In section 7 we finally sketch the development of the Brazilian Pharmacopoeia and compare the herbal drugs included in the latest version with those herbal drugs licenced by the 'Agência Nacional de Vigilância Sanitária do Brasil' (ANVISA database 2016, see Carvalho et al, 2018) and those included in a popular book entitled 'Plantas Medicinais no Brasil: Nativas e Exóticas' (Lorenzi and Matos, 2008). We showcase how exotic species dominate the officinal and licenced products and highlight the untapped potential of traditional herbal medicine and biodiversity of Brazil.…”

Section: Organization Of the Textmentioning

confidence: 99%

“…2, Monografias 5 a edição") comprises only 55 herbal drug aggregates (see Table 3). The 359 herbal medicinal products licensed in Brazil contain herbal drugs derived from 101 different species (Carvalho et al, 2018). Of these "eight are native endemic, 19 are native non-endemic, six are naturalized, six are cultivated, and 62 are not originated in Brazil" (Carvalho et al, 2018).…”

Section: Herbal Drug Monographs In the Brazilian Pharmacopoeia And Thmentioning

confidence: 99%

The historical development of pharmacopoeias and the inclusion of exotic herbal drugs with a focus on Europe and Brazil

Martins

Rodrigues²,

Casu

et al. 2019

Journal of Ethnopharmacology

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In spite of the rich bio-cultural diversity found in the Neotropics relatively few herbal drugs native to South America are included in the global pharmacopoeia. Material and methods: In the attempt to historically explain the inclusion of herbal drugs into official pharmacopoeias we consider the disparate epidemiology and cultural evolution of the New and the Old World. We then trace the development of pharmacopoeias and review forces that worked towards and against the synchronization of pharmacopoeias and highlight the role of early chemical and pharmacological studies in Europe. Finally, we compare the share of exotic and native herbal drug species included in the Brazilian Pharmacopoeia with the share of exotic and native species included in the European Pharmacopoeia as well as those used for products registered with ANVISA. Results: The domination of Eurasian herbal drugs in the European Pharmacopoeia seems to be conditioned by the geographical extension of Eurasia, which facilitated the interchange of materia medica and the creation of a consensus of use since ancient times. At the time of the Conquest the epidemiology of the Amerindian populations resembled that of pre-agriculturalist societies while no written consensus around efficacious medicine existed. Subsequently, introduced and well-tried plant species of the Old World gained therapeutic importance in the New World. Conclusion: The research focus in Europe and the US resulted in a persistence of herbal drugs with a historic importance in the European and US pharmacopoeias, which gained a status as safe and efficacious. During the last decades only few ethnopharmacological field-studies have been conducted with indigenous Amerindian groups living in the Brazilian Amazon, which might be attributable to difficulties in obtaining research permissions. Newly adopted regulations regarding access to biodiversity and traditional knowledge as well as the simplified procedure for licencing herbal medicinal products in Brazil prospects an interesting future for those aiming at developing herbal medicine based on bio-cultural diversity and respecting the protocols regulating benefit sharing. an estimated 90,000 to 110,000 plant species (Antonelli and Sanmartín, 2011), half of which occur in the Amazon basin (Hubbell et al., 2008). With up to 50,000 species, Brazil has the largest flora in the Neotropics (Lewinsohn and Prado, 2005; Shepherd, 2003; Ulloa et al., 2017). Besides a rich biodiversity around 300 Amerindian groups (including ca. 900,000 individuals) associated with 274 different languages are living

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The Brazilian market of herbal medicinal products and the impacts of the new legislation on traditional medicines

Cited by 58 publications

References 3 publications

Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential

Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential

Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects

The historical development of pharmacopoeias and the inclusion of exotic herbal drugs with a focus on Europe and Brazil

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