The brain-to-blood efflux transport of taurine and changes in the blood–brain barrier transport system by tumor necrosis factor-α

Lee, Na-Young; Kang, Young‐Sook

doi:10.1016/j.brainres.2004.07.033

Cited by 37 publications

(29 citation statements)

References 24 publications

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“…The uptake of [ (Tomi et al, 2006). Also, it is reported that there is the efflux pump for taurine at the blood-brain barrier to reduce taurine concentration in the brain interstitial fluid (Lee and Kang, 2004). In our results, [ 3 H]taurine efflux was also observed in a time, Na ＋ and Cl − dependent manner in TR-iBRB cells (Table I).…”

Section: Discussionsupporting

confidence: 78%

The Change of Taurine Transport in Variable Stress States through the Inner Blood-Retinal Barrier using In Vitro Model

Kang¹,

Lee²,

Chung³

2009

Biomolecules and Therapeutics

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-Taurine is the most abundant free amino acid in the retina and transported into retina via taurine transporter (TauT) at the inner blood-retinal barrier (iBRB). In the present study, we investigated whether the taurine transport at the iBRB is regulated by oxidative stress or disease-like state in a conditionally immortalized rat retinal capillary endothelial cell line (TR-iBRB) used as an in vitro model of iBRB.

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Section: Discussionsupporting

confidence: 78%

The Change of Taurine Transport in Variable Stress States through the Inner Blood-Retinal Barrier using In Vitro Model

Kang¹,

Lee²,

Chung³

2009

Biomolecules and Therapeutics

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“…Thus, further nuclei-specific analyses should provide more insight into Tau's regulatory actions upon gene expression and feeding behavior. Because BBB cells and neurons express Tau transporter (Borg et al1976;Huxtable and Lippincott 1982;Lee and Kang 2004), it is plausible that at least part of the effects of Tau supplementation described here occur due to a direct action upon the hypothalamic nuclei. In support of this notion, hypothalamic Tau concentration was dramatically elevated in supplemented mice.…”

Section: Discussionmentioning

confidence: 98%

Taurine supplementation preserves hypothalamic leptin action in normal and protein-restricted mice fed on a high-fat diet

et al. 2015

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Malnutrition programs the neuroendocrine axis by disruption of food-intake control, leading to obesity. Taurine (Tau) is neuroprotective and improves anorexigenic actions in the hypothalamus. We evaluated the hypothalamic gene-expression profile and food-intake control in protein-restricted mice submitted to a high-fat diet (HFD) and Tau supplementation. Mice were fed on a control (14 % protein-C) or a protein-restricted diet (6 % protein-R) for 6 weeks. Thereafter, mice received, or not, HFD for 8 weeks (CH and RH) with or without 5 % Tau supplementation (CHT and RHT). Protein restriction led to higher food intake, but calories were matched to controls. Excessive calorie intake occurred in HFD mice and this was prevented by Tau supplementation only in the CH group. Additionally, RH and CH mice developed hypothalamic leptin resistance, which was prevented by Tau. Global alterations in the expressions of genes involved in hypothalamic metabolism, cellular defense, apoptosis and endoplasmic reticulum stress pathways were induced by dietary manipulations and Tau treatment. The orexigenic peptides NPY and AgRP were increased by protein restriction and lowered by the HFD. The anorexigenic peptide Pomc was increased by HFD, and this was prevented by Tau only in CH mice. Thus, food intake was disrupted by dietary protein restriction and obesity. HFD-induced alterations were not enhanced by previous protein deficiency, but the some beneficial effects of Tau supplementation upon food intake were blunted by protein restriction. Tau effects upon feeding behavior control are complex and involve interactions with a vast gene network, preventing hypothalamic leptin resistance.

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“…We have recently demonstrated that anti-P antibodies up-regulate the expression of tumor necrosis factor ␣ protein and messenger RNA in human peripheral blood monocytes (20). Since tumor necrosis factor ␣ has been found to abrogate the integrity of the blood-brain barrier (21,22), it is likely that serum anti-P antibodies might also induce blood-brain barrier impairment and thus allow anti-NR2 in the systemic circulation to enter the CNS, leading to the development of neuronal damage. However, further studies would be needed to confirm this.…”

Section: Discussionmentioning

confidence: 99%

Association of cerebrospinal fluid anti–NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus

Arinuma¹,

Yanagida²,

Hirohata³

2008

Arthritis & Rheumatism

220

130

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Results. Purified anti-NR2 bound to the surface of SK-N-MC cells. Levels of anti-NR2 antibodies in CSF were significantly elevated in patients with diffuse NPSLE compared with levels in control patients or those with focal NPSLE, whereas there were no significant differences in serum anti-NR2 levels among the 3 groups. In 31 of the 38 patients with diffuse NPSLE (81.6%) and 8 of the 18 patients with focal NPSLE (44.4%), CSF anti-NR2 levels were more than 3 SD above the mean level in the control patients (P ‫؍‬ 0.0120 by chi-square test). Conclusion.These results indicate that anti-NR2 is a constituent of antineuronal antibodies and, more importantly, that anti-NR2 antibodies in CSF, but not in serum, are associated with diffuse NPSLE.

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The brain-to-blood efflux transport of taurine and changes in the blood–brain barrier transport system by tumor necrosis factor-α

Cited by 37 publications

References 24 publications

The Change of Taurine Transport in Variable Stress States through the Inner Blood-Retinal Barrier using In Vitro Model

The Change of Taurine Transport in Variable Stress States through the Inner Blood-Retinal Barrier using In Vitro Model

Taurine supplementation preserves hypothalamic leptin action in normal and protein-restricted mice fed on a high-fat diet

Association of cerebrospinal fluid anti–NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus

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