Taurine supplementation preserves hypothalamic leptin action in normal and protein-restricted mice fed on a high-fat diet

Camargo, Rafael Ludemann; Batista, Thiago M.; Ribeiro, Rosane Aparecida; Branco, Renato Chaves Souto; Silva, Priscilla M. R. da; Izumi, Clarice; Araújo, Thiago R.; Greene, Lewis J.; Boschero, Antônio Carlos; Carneiro, Everardo M.

doi:10.1007/s00726-015-2035-9

Cited by 30 publications

(21 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the HFD feeding did not promoted an additional effect on NPY mRNA levels in Middle-Age mice. Besides that, it has been shown that the Npy mRNA levels increase after 2 weeks and decrease after 12 weeks of HFD treatment [ 29 , 30 ], demonstrating that chronic exposure to HFD induces NPY mRNA stabilization in the hypothalamus and other mechanisms cold be involved in the body weight gain during the long-term of HFD treatment.…”

Section: Discussionmentioning

confidence: 99%

Chronic exercise reduces hypothalamic transforming growth factor-β1 in middle-aged obese mice

Silva

Katashima

Lenhare

et al. 2017

Aging

Self Cite

View full text Add to dashboard Cite

Obesity and aging are associated with hypothalamic inflammation, hyperphagia and abnormalities in the thermogenesis control. It has been demonstrated that the association between aging and obesity induces hypothalamic inflammation and metabolic disorders, at least in part, through the atypical hypothalamic transforming growth factor-β (TGF-β1). Physical exercise has been used to modulate several metabolic parameters. Thus, the aim of this study was to evaluate the impact of chronic exercise on TGF-β1 expression in the hypothalamus of Middle-Aged mice submitted to a one year of high-fat diet (HFD) treatment. We observed that long-term of HFD-feeding induced hypothalamic TGF-β1 accumulation, potentiated the hypothalamic inflammation, body weight gain and defective thermogenesis of Middle-Aged mice when compared to Middle-Aged animals fed on chow diet. As expected, chronic exercise induced negative energy balance, reduced food consumption and increasing the energy expenditure, which promotes body weight loss. Interestingly, exercise training reduced the TGF-β1 expression and IkB-α ser32 phosphorylation in the hypothalamus of Middle-Aged obese mice. Taken together our study demonstrated that chronic exercise suppressed the TGF-β1/IkB-α axis in the hypothalamus and improved the energy homeostasis in an animal model of obesity-associated to aging.

show abstract

Section: Discussionmentioning

confidence: 99%

Chronic exercise reduces hypothalamic transforming growth factor-β1 in middle-aged obese mice

Silva

Katashima

Lenhare

et al. 2017

Aging

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, the HF pups presented a significant reduction in the food intake. This reduced food intake can be attributed to the high energy density of the HF diet (19•87 v. 15•10 kJ/g (4•75 cal/g v. 3•61 kcal/g)) (37) . Diets containing 30 % or more of energy derived from fat induce satiety in rodents as a result of increased energy intake and efficiency of energy storage (38,39) .…”

Section: Discussionmentioning

confidence: 99%

Effects of high-fat diet on somatic growth, metabolic parameters and function of peritoneal macrophages of young rats submitted to a maternal low-protein diet

et al. 2017

View full text Add to dashboard Cite

This study evaluated the effects of a post-weaning high-fat (HF) diet on somatic growth, food consumption, metabolic parameters, phagocytic rate and nitric oxide (NO) production of peritoneal macrophages in young rats submitted to a maternal low-protein (LP) diet. Male Wistar rats (aged 60 d) were divided in two groups (n 22/each) according to their maternal diet during gestation and lactation: control (C, dams fed 17 % casein) and LP (dams fed 8 % casein). At weaning, half of the groups were fed HF diet and two more groups were formed (HF and low protein-high fat (LP-HF)). Somatic growth, food and energy intake, fat depots, serum glucose, cholesterol and leptin concentrations were evaluated. Phagocytic rate and NO production were analysed in peritoneal macrophages under stimulation of zymosan and lipopolysaccharide (LPS)+interferon γ (IFN-γ), respectively. The maternal LP diet altered the somatic parameters of growth and development of pups. LP and LP-HF pups showed a higher body weight gain and food intake than C pups. HF and LP-HF pups showed increased retroperitoneal and epididymal fat depots, serum level of TAG and total cholesterol compared with C and LP pups. After LPS+IFN-γ stimulation, LP and LP-HF pups showed reduced NO production when compared with their pairs. Increased phagocytic activity and NO production were seen in LP but not LP-HF peritoneal macrophages. However, peritoneal macrophages of LP pups were hyporesponsive to LPS+IFN-γ induced NO release, even after a post-weaning HF diet. Our data demonstrated that there was an immunomodulation related to dietary fatty acids after the maternal LP diet-induced metabolic programming.

show abstract

“…A cause for these variant observations was not evident. Studies with mice show that TAU may moderately reduce food intake when consumed in excess (Camargo et al., ). But in the present study, food intake was not significantly affected by dietary TAU concentration (Table ).…”

Section: Discussionmentioning

confidence: 99%

Effect of increasing taurine and methionine supplementation on urinary taurine excretion in a model insectivore, the giant anteater (Myrmecophaga tridactyla)

Nofs¹,

Dierenfeld²,

Backus

2017

Animal Physiology Nutrition

View full text Add to dashboard Cite

SummaryThe giant anteater (Mymercophaga tridactyla) is a highly specialized insectivore for which nutrient requirements are not clearly established, making diet formulation challenging for this species. Multiple clinical reports suggest anteaters have an obligate dietary taurine (TAU) requirement. Sulphur amino acid (SAA) metabolism in adult anteaters was evaluated using noninvasive methods to measure TAU synthesis potential from dietary methionine (MET) and a basal diet containing on a dry matter (DM) basis 1.7 mg TAU/kg DM and 6.9 g MET/kg DM. Urinary equilibrium times for TAU excretion were determined by feeding the basal diet with or without 1.5 g/kg DM supplemental TAU (crossover design; n = 4). Effects of supplemental dietary TAU (1.7, 2.0, 2.4, 2.7, 3.0, 3.3 g/kg DM) or MET (6.9, 9.0, 11.2 g/kg DM) on urinary TAU were evaluated (randomized block trials; n = 5 or 4 respectively). All urinary values (TAU, MET, unbound inorganic sulphate) were normalized to creatinine (CRT). Results indicate urinary TAU equilibrium in anteaters requires at least 2 weeks of feeding. Urinary ratio of TAU to CRT (TAU:CRT) increased as dietary TAU content increased from 1.7 to 3.0 g/kg DM, consistent with renal homoeostatic modulation of TAU excretion. Our data indicate that TAU needs were met by TAU in the basal diet or by de novo synthesis. Supplemental MET resulted in ~five-to eightfold increases in urinary TAU:CRT excretion, further supporting existence of mechanisms for TAU synthesis from dietary SAA in anteaters. Adult anteaters appear able to synthesize TAU when diets contain adequate SAA, but dietary TAU may be critical if protein intakes are low or of poor quality. This study may provide guidance on choice of domestic canids vs. felids as suitable physiologic models for improved nutrition in giant anteaters, and also outlines a noninvasive method for assessing TAU status/metabolism that may be useful across (Van Vleet & Ferrans, 1986).Vitamin E and TAU deficiencies as causal factors in the development of cardiomyopathy have been reported for several species. In a case of cardiomyopathy in flying foxes (Pteropus spp.) under human care, plasma vitamin E levels were reported to be unmeasurable in bats clinically diagnosed with cardiomyopathy, and critically low to unmeasurable in bats in the same group without a cardiomyopathy diagnosis (Heard, Buergelt, Snyder, Voges, & Dierenfeld, 1996). In this case, TAU plasma levels were reported as above 20 nmol/ml, concentrations not commonly associated with TAU-deficiency cardiomyopathy in domes- Although in many species TAU is a byproduct of cysteine degradation, cats, some dogs, foxes and some primate species may lack the capacity to synthesize sufficient amounts of TAU to maintain adequate levels (reviewed in Schaffer, Ito, & Azuma, 2014). The reported effects of TAU deficiency include tapetal and retinal degeneration, immune deficiency, muscle atrophy, premature ageing, impaired reproduction and cardiac dysfunction (Schaffer et al., 2014). Domestic cats appear to have low enz...

show abstract

Taurine supplementation preserves hypothalamic leptin action in normal and protein-restricted mice fed on a high-fat diet

Cited by 30 publications

References 64 publications

Chronic exercise reduces hypothalamic transforming growth factor-β1 in middle-aged obese mice

Chronic exercise reduces hypothalamic transforming growth factor-β1 in middle-aged obese mice

Effects of high-fat diet on somatic growth, metabolic parameters and function of peritoneal macrophages of young rats submitted to a maternal low-protein diet

Effect of increasing taurine and methionine supplementation on urinary taurine excretion in a model insectivore, the giant anteater (Myrmecophaga tridactyla)

Contact Info

Product

Resources

About