The Brain Derived Neurotrophic Factor and Personality

Montag, Christian

doi:10.1155/2014/719723

Cited by 18 publications

(9 citation statements)

References 131 publications

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“…This underlines the already described associations between Internet addiction and depression (see Sariyska et al, 2015), but also links between Internet addiction and neuroticism (e.g., Hardie and Tee, 2007; Montag et al, 2010). It has been discussed (Davis and Panksepp, 2011; Montag, 2014) that individual differences in primary emotional systems could represent the evolutinary oldest parts of human personality and FEAR/SADNESS seem to be robustly associated with neuroticism (see Montag et al, 2013; Sindermann et al, 2016). …”

Section: Discussionmentioning

confidence: 99%

An Affective Neuroscience Framework for the Molecular Study of Internet Addiction

Montag

Sindermann²,

Becker

et al. 2016

Front. Psychol.

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Internet addiction represents an emerging global health issue. Increasing efforts have been made to characterize risk factors for the development of Internet addiction and consequences of excessive Internet use. During the last years, classic research approaches from psychology considering personality variables as vulnerability factor, especially in conjunction with neuroscience approaches such as brain imaging, have led to coherent theoretical conceptualizations of Internet addiction. Although such conceptualizations can be valuable aid, the research field is currently lacking a comprehensive framework for determining brain-based and neurochemical markers of Internet addiction. The present work aims at providing a framework on the molecular level as a basis for future research on the neural and behavioral level, in order to facilitate a comprehensive neurobiological model of Internet addiction and its clinical symptomatology. To help establish such a molecular framework for the study of Internet addiction, we investigated in N = 680 participants associations between individual differences in tendencies toward Internet addiction measured by the Generalized Problematic Internet Use Scale-2 (GPIUS-2) and individual differences in primary emotional systems as assessed by the Affective Neuroscience Personality Scales (ANPS). Regression analysis revealed that the ANPS scales FEAR and SADNESS were the ANPS scales most robustly positively linked to several (sub)scales of the GPIUS-2. Also the scales SEEKING, CARE and PLAY explain variance in some of the GPIUS-2 subscales. As such, these scales are negatively linked to the GPIUS-2 subscales. As the ANPS has been constructed on substantial available brain data including an extensive molecular body with respect to evolutionary highly conserved emotional circuitry in the ancient mammalian brain, the present study gives first ideas on putative molecular mechanisms underlying different facets of Internet addiction as derived from associations between tendencies toward Internet addiction and individual differences in primary emotional systems. For example, as SADNESS is linked to the overall GPIUS-2 score, and the neuropeptide oxytocin is known to downregulate SADNESS, it is conceivable that the neuropeptide might play a role in Internet addition on the molecular level. Our findings provide a theoretical framework potentially illuminating the molecular underpinnings of Internet addiction. Finally, we also present data on the ANPS and smartphone addiction at the end of the paper. Similar to the reported associations between the ANPS and the GPIUS-2, these correlations might provide an initial outline for a framework guiding future studies that aim to address the molecular basis of smartphone addiction.

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Section: Discussionmentioning

confidence: 99%

An Affective Neuroscience Framework for the Molecular Study of Internet Addiction

Montag

Sindermann²,

Becker

et al. 2016

Front. Psychol.

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“…psychoanalytic theory of personality, phenomenological theory of personality, trait approaches to personality, learning approaches to personality, cognitive theory of personality) have been sophisticated enough to observe the interactions between constitution of subcortical affective systems and environmental factors. As an important part of personality clearly refers to individual differences in emotional reactions over a wide range of environmental situations, individual differences in emotionality may arise heavily from the phylogenetically oldest part of human and animal personalities, because it is anchored in evolutionary oldest subcortical networks of human and animal brains (Panksepp 1998;Montag 2014). Despite the fact that these archaic subcortical networks are the essential basis for the development of self, the psychometric studies utilizing the personality scalesderived from the personality theories stated above-have overseen this crucial point.…”

Section: Introductionmentioning

confidence: 99%

The influence of culture on basic affective systems: the comparison of Turkish and American norms on the affective neuroscience personality scales

et al. 2014

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The affective neuroscience personality scales (ANPS) aims to measure brain affective systems with the help of seven subscales: PLAY, SEEK, CARE, FEAR, ANGER and SADNESS, along with a spirituality subscale. From an affective neuroscience perspective, personality is substantially related to constitutional and developmental strengths and weaknesses in these basic subcortical emotional systems shared by all mammals. This study summarizes the standardization of the Turkish ANPS and its comparison to American ANPS norms. The Turkish translation of ANPS has been completed by 890 participants (245 of these composing an adult group and the remaining composing the university students group). 327 students out of this sample also completed a Goldberg-based Big-Five Scales (B5S), which was included in the validation of the Turkish ANPS. The obtained means and intercorrelations of the subscales on ANPS show both similarities and differences with the results attained from the study of Americans with ANPS. Gender comparisons in both cultures are mostly the same, with females having higher scores on SADNESS, CARE and Spirituality. The intercorrelations between Turkish version of ANPS and the B5S are mostly in line with the intercorrelations obtained in the original American study. Based on the results, the Turkish ANPS has sufficient reliability and construct validity. The similarities among the two ANPS studies are discussed in terms of the universal characteristics of basic affective systems, whereas the differences are discussed in the light of influences of cultural norms-as Turkish culture is more collectivistic than American culture which is more individualistic. The results of our study shows the need of carrying out further cross-cultural affective neuroscience researches to observe the influence of culture on the development of basic affective systems.

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“…Since BDNF has been mostly studied in animal models and the few human studies are in the context of pathological conditions (e.g., mood and psychiatric disorders) or based on its genes, homeostatic information is very limited [29][30][31][32][33][34]. Although genetic studies have been highly informative, epigenetic changes are equally relevant in this context.…”

Section: Discussionmentioning

confidence: 99%

Among Adolescents, BDNF and Pro-BDNF Lasting Changes with Alcohol Use Are Stage Specific

et al. 2020

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Adolescent alcohol use demonstrates distinct developmental trajectories with dissimilar times of onset and trajectories. Given the importance of brain-derived neurotrophic factor (mature BDNF) in this development stage, the current study investigated its relationship with alcohol use. It also extends the literature by assessing the role of its precursor (pro-BDNF). Therefore, over the span of 5 years, we enrolled and followed participants to define age-related changes in BDNF levels in healthy adolescents. Then, the onset and frequency of alcohol use from ages 11 to 18 were collected to determine how the relationship between alcohol, pro-BDNF, and m-BDNF unfolds over time. With respect to development, analyses demonstrated that BDNF concentration slowly increases throughout adolescence. However, despite having similar basal BDNF levels, compared to controls, adolescents that started drinking before 15 years of age always exhibited lower BDNF levels. They also had a significant decrease in pro-BDNF levels. On the other hand, levels of mature BDNF steadily increased (974.896±275 pg/ml) in those starting alcohol use after the age of 15. Similar to the younger users, a significant drop in pro-BDNF levels was observed over the course of the study. Our results suggested that both pathways may participate in the complex processes of alcohol dependence. The findings highlight the relevance of assessing alcohol-associated changes across the different phases of this vulnerable developmental period. This is the first study evidencing that m-BDNF changes associated with drinking behaviors differed between young and older adolescents. It is also the first article, documenting that drinking during adolescence leads to long-term decreases in pro-BDNF. These results have important implications for policies and programs targeting alcohol use disorders.

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The Brain Derived Neurotrophic Factor and Personality

Cited by 18 publications

References 131 publications

An Affective Neuroscience Framework for the Molecular Study of Internet Addiction

An Affective Neuroscience Framework for the Molecular Study of Internet Addiction

The influence of culture on basic affective systems: the comparison of Turkish and American norms on the affective neuroscience personality scales

Among Adolescents, BDNF and Pro-BDNF Lasting Changes with Alcohol Use Are Stage Specific

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