The brain‐derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with increased body mass index and insulin resistance measures in bipolar disorder and schizophrenia

Abstract

The positive association of BNDF Val66Met with high BMI values replicates previous findings in patients with SCZ and indicates the BDNF Val66Met genotype as a potential risk factor for obesity and insulin resistance measures in patients with BPD receiving antipsychotics as well.

Potential unfavorable impacts of BDNF Val66Met polymorphisms on metabolic risks in average population in a longevous area

“…BMI is one of the most important indicators for obesity assessment. Several previous studies had implicated that the derived Met allele of BDNF gene might down-regulate BDNF, raise blood glucose concentration and predispose individuals to obesity [12, 13, 23, 24]. In the present work, BDNF Met allele carriers with normal BMI and lipid levels in OG displayed lower BMI whereas Met carriers with normal lipids in CG exhibited higher BMI level and risk of overweight, demonstrating a different impact pattern of BDNF Met on body shape between the offspring of nonagenarians and the age-matched controls.…”

“…These observations demonstrated a pronounced influence of BDNF on glucose homeostasis. However, Bonaccorso et al [13] detected no different glucose level between Met and non-Met carriers in patients with bipolar and schizoaffective disorder, indicating the uncertainty affecting pattern of BDNF on glucose metabolism. In the present study, a lowered FPG was only noted in the BDFN GA/AA carriers of euglycemic and normolipidemic subgroup of LG but not in any genotype of other groups, implying a limited effect of BDNF rs6265 on blood glucose modulation in our studying populations.…”

“…In humans, serum BDNF levels were found to be significantly higher in type 2 diabetic patients than in the healthy controls and positively correlated with triglyceride level [43]. As compared to non-Met, BDNF 66Met carriers with bipolar disorder showed a greater increase in triglycerides and triglycerides/HDL-C ratio after three or six months of antipsychotic therapy [13]. We noted herein similar correlation trend between BDNF Val66Met and lipid profiles where Met allele was essentially linked to elevated triglyceride but lowered HDL-C level relative to non-Met bearers, particularly in the control and offspring groups.…”

“…schizophrenia, psychosis, major depression, anxiety, and eating disorders), cognitive compromised disorders (e.g. AD and PD) and metabolic syndrome [13–15], very little data are available on its association with metabolic risks in general population, especially in long-lived individuals with good cognitive function.…”

rs10767664 Gene Variant in Brain-Derived Neurotrophic Factor Is Associated with Diabetes Mellitus Type 2 in Caucasian Females with Obesity

“…Authors found a significant association between glucose levels and Val66Met polymorphism in males, but not in females. Finally, in another study [27] BMI was significantly greater in all Met66 allele carriers at 6 months. Met66 carriers showed a greater increase in the triglycerides/HDL cholesterol ratio, a key marker for metabolic syndrome related to insulin resistance.…”