The blood compatibility challenge. Part 4: Surface modification for hemocompatible materials: Passive and active approaches to guide blood-material interactions

Maitz, Manfred F.; Martins, M. Cristina L.; Grabow, Niels; Matschegewski, Claudia; Huang, Nan; Chaikof, Elliot L.; Barbosa, Mário A.; Werner, Carsten; Sperling, Claudia

doi:10.1016/j.actbio.2019.06.019

Cited by 91 publications

(114 citation statements)

References 133 publications

Supporting

Mentioning

110

Contrasting

Unclassified

Order By: Relevance

“…While choice of materials is often limited by fabrication practicality, various surface modification techniques have been developed to enhance the material hemocompatibility of commonly accessible materials. 20 Some common surface modification strategies designed to increase hemocompatibility will be explored in this review.…”

Section: Defining Hemocompatibility In Lab-on-a-chip Systemmentioning

confidence: 99%

“…As a result, significant interest is evident in the literature on surface modification techniques intended to enhance hemocompatibility and performance of biomaterials. 20,[74][75][76] The process of "surface passivation" confers a coating upon a biomaterial surface to prevent subsequent bonding or interaction of blood components; some common methods of surface passivation are conceptually outlined in ►Fig. 2 (A), with a summary of strategies employed to increase material hemocompatibility outlined in ►Fig.…”

Section: Surface Modification-increasing Hemocompatibilitymentioning

confidence: 99%

“…91,92 Their comparatively simple synthesis makes SAMs technologically attractive for surface engineering, and a great deal of interest is evident in the literature regarding their application to antifouling and hemocompatible surfaces. 20,76,[93][94][95] Commonly utilized SAMs often consist of organosilane species that bond with oxidized glass, silicon, PDMS, and metal oxides 95 or organosulfur (thiol-derivates) bound to metals. 92 SAMs are generally deposited in either liquid or vapor phase, and are advantageous over other passivation methods due to the potential for generation of coatings with long shelf-life.…”

Section: Charged Polymer Passivationmentioning

confidence: 99%

See 2 more Smart Citations

A Review of Design Considerations for Hemocompatibility within Microfluidic Systems

Szydzik

Brazilek

Nesbitt

2020

Semin Thromb Hemost

View full text Add to dashboard Cite

The manipulation of blood within in vitro environments presents a persistent challenge, due to the highly reactive nature of blood, and its multifaceted response to material contact, changes in environmental conditions, and stimulation during handling. Microfluidic Lab-on-Chip systems offer the promise of robust point-of-care diagnostic tools and sophisticated research platforms. The capacity for precise control of environmental and experimental conditions afforded by microfluidic technologies presents unique opportunities that are particularly relevant to research and clinical applications requiring the controlled manipulation of blood. A critical bottleneck impeding the translation of existing Lab-on-Chip technology from laboratory bench to the clinic is the ability to reliably handle relatively small blood samples without negatively impacting blood composition or function. This review explores design considerations critical to the development of microfluidic systems intended for use with whole blood from an engineering perspective. Material hemocompatibility is briefly explored, encompassing common microfluidic device materials, as well as surface modification strategies intended to improve hemocompatibility. Operational hemocompatibility, including shear-induced effects, temperature dependence, and gas interactions are explored, microfluidic sample preparation methodologies are introduced, as well as current techniques for on-chip manipulation of the whole blood. Finally, methods of assessing hemocompatibility are briefly introduced, with an emphasis on primary hemostasis and platelet function.

show abstract

Section: Defining Hemocompatibility In Lab-on-a-chip Systemmentioning

confidence: 99%

Section: Surface Modification-increasing Hemocompatibilitymentioning

confidence: 99%

Section: Charged Polymer Passivationmentioning

confidence: 99%

See 1 more Smart Citation

A Review of Design Considerations for Hemocompatibility within Microfluidic Systems

Szydzik

Brazilek

Nesbitt

2020

Semin Thromb Hemost

View full text Add to dashboard Cite

show abstract

“…Generally speaking, ideal medical implants should have the abilities to integrate and communicate with surrounding tissues or cells, trigger speci c cell responses and maintain the function of tissues and organs, and prevent infections caused by microorganisms after the implantation [3,4]. In this regard, surface functionalization represents one of the straightforward and effective methods to endow biomaterials with excellent properties and functions [5,6]. According to the mechanism of the interaction between the implant and the surrounding physiological environment, the introduction of bioactive factors on the surface by physical or chemical conjugation can endow the inert biomaterial with good biological activities, so as to regulate the cellmaterial interaction behaviors, induce speci c cell responses, and prevent the infection caused by implantation and related biological effects [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Assembly of Gentamicin and Zn2+ Loaded Coatings on TiO2 Nanotubes to Synergistically Improve the Blood Compatibility, Endothelial Cell Growth and Antibacterial Activities

Pan

Yang

et al. 2020

Preprint

View full text Add to dashboard Cite

Titanium and its alloys are widely used in blood contacting implantable and interventional medical devices; however, their biocompatibility is still facing great challenges. In this study, with the aim of improving the biocompatibility and antibacterial activities of titanium, TiO2 nanotubes with a diameter of about 30 nm were firstly prepared on the titanium surface by anodization, followed by the introduction of polyacrylic acid (PAA) and gentamicin (GS) on the nanotube surface by layer-by-layer method, and finally zinc ions were loaded into the surface to improve the bioactivities. The nanotubes have excellent hydrophilic properties and special nanotube-like structure, which can selectively promote the albumin adsorption and enhance the blood compatibility and promote the growth and functional expression of endothelial cells to a certain extent. After the introduction of PAA and GS, although the super-hydrophilicity cannot be achieved, the results of platelet adhesion, cGMP activity, hemolysis rate and partial thromboplastin time (APTT) showed that the blood compatibility was improved, and the blood compatibility was further enhanced after zinc ions loading on the surface. On the other hand, the surface modified materials showed good cytocompatibility to endothelial cells. The introduction of PAA and zinc ions not only promoted the adhesion and proliferation of endothelial cells, but also up-regulated expression of vascular endothelial growth factor (VEGF) and nitric oxide (NO). The slow and continuous release of GS and Zn2+ for more than 14 days, which can significantly improve the antibacterial properties of the materials. Therefore, the present study provides an effective method for the surface modification of titanium-based blood-contacting materials to simultaneously endow with good blood compatibility, endothelial growth behaviors and antibacterial properties.

show abstract

“…В настоящее время существует три основные стратегии, используемые для увеличения тромборезистентности поверхностей, контактирующих с кровью. К ним относятся создание биоактивной поверхности с использованием антитромботических агентов, пассивация поверхности имплантатов гидрофильными и цвиттер-ионными полимерами, которые препятствуют контакту основного материала изделия с кровью и предотвращают неспецифическую адгезию белка, и эндотелизация внутренней поверхности имплантата [5][6][7].…”

unclassified

Approaches to antithrombotic modification of vascular implants

et al. 2020

View full text Add to dashboard Cite

Vascular implants in contact with blood must have high thrombotic resistance. However, in some cases, their implantation is associated with thrombosis and subsequent impaired patency of the blood vessel. Most often, this problem affects implants intended for reconstruction of small diameter vessels, which is associated with hemodynamic features in this part of the bloodstream. These include blood vessel prostheses, tissue-engineered vascular grafts, and endovascular stents. The features of the implant material are of great importance when choosing a method for its modification in order to improve biocompatibility and thromboresistance. The review analyzes current experience in using various methods of immobilizing drugs to the surface of vascular prostheses and endovascular stents made from stable and biodegradable polymers. The prospects of creating thromboresistant vascular grafts and stents by joint immobilization on the surface of the polymer material of drugs with antithrombogenic activity and biologically active molecules that regulate the reaction to a foreign body and implant remodeling were evaluated. Numerous studies in the review demonstrating a wide range of ways to modify blood vessel prostheses, tissue-engineered vascular grafts, and endovascular stents with antithrombotic drugs to increase their thrombosis resistance. The main approaches of antithrombotic modification include conjugation of drugs and biologically active molecules on the implant surface. At the same time, new technologies are aimed not only at inhibiting the process of thrombus formation, but also at reducing the intensity of the inflammation process and stimulating the reparation of vascular tissue.

show abstract

The blood compatibility challenge. Part 4: Surface modification for hemocompatible materials: Passive and active approaches to guide blood-material interactions

Cited by 91 publications

References 133 publications

A Review of Design Considerations for Hemocompatibility within Microfluidic Systems

A Review of Design Considerations for Hemocompatibility within Microfluidic Systems

Assembly of Gentamicin and Zn2+ Loaded Coatings on TiO2 Nanotubes to Synergistically Improve the Blood Compatibility, Endothelial Cell Growth and Antibacterial Activities

Approaches to antithrombotic modification of vascular implants

Contact Info

Product

Resources

About