The Birth Prevalence of Cleft Lip and Palate in Canadian Aboriginal Peoples

Vrouwe, Sebastian Q; Lowry, R. Brian; Olson, Jaret; Wilkes, Gordon H.

doi:10.1097/prs.0b013e318289d045

Cited by 8 publications

(9 citation statements)

References 5 publications

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“…The rates of family history of cleft were not significantly different in cases with nonsyndromic or syndromic cleft. Boys were more common among CL and CLP cases, and girls more common among CP cases, a finding similar to other studies across various ethnic groups (Calzolari et al, 2004; Vallino-Napoli et al, 2006; Calzolari et al, 2007; Li et al, 2008; Genisca et al, 2009; Rittler et al, 2009; Wang et al, 2009; Dai et al, 2010; Parker et al, 2010; Rozendaal et al, 2011; IPDTOC Working Group, 2011; Vrouwe et al, 2013).…”

Section: Discussionsupporting

confidence: 88%

“…The prevalence was greater in Phatthalung than Trang and Songkhla provinces, but there were no statistically significant variations between the years of the study period, and all had overlapping 95% CIs. The distribution of oral clefts in our current study was similar to distribution rates in Caucasian countries, where studies have found CLP was the most common type involving 40% to 50% of cases, followed by CP at 30% to 40% and CL at 20% to 30% (Genisca et al, 2009;Rittler et al, 2009;Parker et al, 2010;IPDTOC Working Group, 2011;Vrouwe et al, 2013) but were lower than in other Asian countries, such as China and Japan, where studies have found the prevalence of oral clefts was greater than in Thailand: 1.5 to 2.0 per 1000 births (Li et al, 2008;Wang et al, 2009;Dai et al, 2010;IPDTOC Working Group, 2011), and the distribution of CL greater than CP (Li et al, 2008;Wang et al, 2009;Dai et al, 2010). We found syndromic forms of cleft in 15.6% of all cases.…”

Section: Discussionsupporting

confidence: 87%

“…The prevalence of oral clefts is 1 to 3 per 1000 live births, with considerable ethnic and geographical variation (Calzolari et al, 2004; Vallino-Napoli et al, 2006; Calzolari et al, 2007; Li et al, 2008; Genisca et al, 2009; Rittler et al, 2009; Wang et al, 2009; Dai et al, 2010; Parker et al, 2010; Rozendaal et al, 2011; IPDTOC Working Group, 2011; Vrouwe et al, 2013). In Thailand, there have been two previous studies of the prevalence of oral clefts based on data from university hospitals: the first during 1969 through 1978 (Siripoonya and Tejavej, 1980) and the second during 1988 through 1999 (Dissaneevate et al, 2003), finding prevalence rates of 1.23 and 1.22 per 1000 live births, respectively.…”

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confidence: 99%

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Population-Based Study of Prevalence of Cleft Lip/Palate in Southern Thailand

Jaruratanasirikul

Chicharoen

Chakranon

et al. 2016

The Cleft Palate-Craniofacial Journal

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 87%

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confidence: 99%

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Population-Based Study of Prevalence of Cleft Lip/Palate in Southern Thailand

Jaruratanasirikul

Chicharoen

Chakranon

et al. 2016

The Cleft Palate-Craniofacial Journal

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“…However, a great variation exists in frequency as well as in the proportion of oral cleft types, according to the time period under study, geographic region or population ethnicity, age of patients, and diagnostic resources. Eleven studies in the USA presented rates for the three types of cleft in live births (Amidei, Hamman, Kassebaum, & Marshall, ; Ching & Chung, ; Conway & Wagner, ; Emanuel, Culver, Erickson, Guthrie, & Schuldberg, ; Greene, Vermillion, Hay, Gibbens, & Kerschbaum, ; Jaffe & De Blanc, ), Canada (Lowry & Renwick, ; Lowry & Trimble, ; Vrouwe, Lowry, Olson, & Wilkes, ), Denmark (Jensen et al, ), and Jordan (Al‐Omari & Al‐Omari, ) (Supplementary Table S1). The pooled frequency rates per 10,000 births were 3.1 for CL, 4.9 for CLP, and 3.4 for CP in the USA; 4.2 for CL, 7.6 for CLP, and 6.7 for CP in Canada; 6.3 for CL, 7.4 for CLP, and 5.2 for CP in Denmark; and 4.2 for CL, 6.6 for CLP, and 3.1 for CP in Jordan.…”

Section: Discussionmentioning

confidence: 99%

ICD‐10 impact on ascertainment and accuracy of oral cleft cases as recorded by the Brazilian national live birth information system

Nascimento

Castilla

Dutra

et al. 2018

American J of Med Genetics Pt A

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We compared Brazilian oral cleft (OC) frequencies between the population-based Brazilian System of Live Birth (SINASC) and the hospital-based Latin American Collaborative Study of Congenital Malformations (ECLAMC), trying to understand the paucity of cleft of lip and palate (CLP) in the first system. SINASC uses the International Classification of Disease version 10 (ICD-10) for congenital defects coding, ECLAMC uses ICD-8 with modifications. In SINASC, the CLP frequency was 1.7 per 10,000 (95% confidence limits 1.7-1.8), cleft lip (CL) 1.6 (1.5-1.7), and cleft palate (CP) 2.0 (1.9-2.1). In ECLAMC, the CLP frequency was 10.4 per 10,000 (9.0-12.1), CL 5.5 (4.5-6.7), and CP 4.4. (4.5-6.7). In SINASC, only 33% of the oral clefts were CLP, versus 51% in ECLAMC. Part of this discrepancy may have been due to the relative excess of CP and CL cases. Although congenital defect frequencies are usually lower in population than in hospital-based registries, differences in the proportion of the main OC categories are not expected and are probably due to ICD-10 coding issues, such as lumping of unilateral CL and CL without other specifications. ICD-10 codes, whose deficiency for oral clefts is fully explained in the literature, lack modifiers for severity, or clinical subtypes. This paper shows the practical aspect of the ICD-10 system deficiency in capturing cleft lip and palate (CLP) subtypes, as demonstrated in SINASC covering three million births per year. Such errors are expected to occur in any registry that uses the ICD-10 coding system, and must be adjusted, given its relevance worldwide.

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“…Prevalence data for OFCs are often presented for CL and CLP combined (i.e., cleft lip with or without cleft palate [CL/P]) and for CP alone. Based on worldwide population-based surveillance data, the overall prevalence (per 10,000 live births) of OFCs ranges from 11.1 to 20.4 [66,[102][103][104][105][106]; the prevalence of CL/P and CP ranges from 8.9 to 13.2 and 4.0 to 7.7, respectively [63,66,102,105,[107][108][109]. Studies of the prevalence of CL have reported estimates from 3.9 to 5.0 [108][109][110].…”

Section: Orofacial Cleftsmentioning

confidence: 99%

Associations between cough medications containing dextromethorphan or guaifenesin and major structural birth defects

Cao¹

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Dextromethorphan and guaifenesin are the main active components in over-thecounter cough medications. Prenatal exposure to dextromethorphan has been shown to be teratogenic in animal models. Data from human studies for either dextromethorphan or guaifenesin are limited and inconclusive. We used data from the population-based National Birth Defects Prevention Study (NBDPS) to examine associations between maternal periconceptional (one month before through three months after conception) use of cough medications containing dextromethorphan, with or without guaifenesin, and isolated neural tube defects (NTDs). We also used NBDPS data to explore associations between such exposures and other isolated major birth defects, as well as associations between maternal periconceptional use of cough medications containing guaifenesin alone and isolated major birth defects. Enrolled cases comprised 19,538 live births, still births, and elective terminations with isolated major birth defects, and enrolled controls comprised 10,200 live births without defects delivered from October 1997 through December 2009. Telephone interview reports of pregnancy exposures, including periconceptional use of cough medications, were obtained from mothers of case and control infants. Two approaches were used to build multivariable models: backward model selection and comparing the change in odds ratios (ORs) by adding each covariable individually into the main effect models. Adjusted ORs (aORs) and 95% confidence intervals (CIs) for maternal periconceptional exposure of cough medications containing dextromethorphan, with or without guaifenesin, or guaifenesin alone, respectively, and 22 types of birth defects were estimated using multivariable logistic iv regression analysis. Applying our first multivariable model building approach, we observed that maternal periconceptional use of dextromethorphan, with or without guaifenesin, was marginally significantly associated with an increased risk of all NTDs combined (aOR=1.7, 95%CI=1.0-2.9), or spina bifida alone (aOR=1.9, 95%CI=1.0-3.5). Applying our second model-building approach confirmed the associations with all NTDs combined and spina bifida alone (aOR==1.9, 95% CI=1.2-3.0 and aOR=2.1, 95% CI=1.2-3.8; respectively). For other isolated birth defects, a positive, marginally significant association was observed for maternal periconceptional use of dextromethorphan, with or without guaifenesin, and cleft lip with or without cleft palate (aOR=1.3, 95%CI=1.0-1.7) applying our first model building approach. Our second model-building approach produced significant associations between such exposure and gastroschisis (aOR=1.8, 95%CI=1.2-2.8). With regard to maternal periconceptional use of cough medications containing guaifenesin alone, we observed marginally significant associations with all NTDs combined (aOR=1.9, 95%CI=1.1-3.5), spina bifida alone (aOR=2.3, 95%CI=1.1-4.4), or anorectal atresia (aOR=1.9, 95%CI=1.0-3.6) applying our first model-building approach. Applying our second model-building approach...

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The Birth Prevalence of Cleft Lip and Palate in Canadian Aboriginal Peoples

Cited by 8 publications

References 5 publications

Population-Based Study of Prevalence of Cleft Lip/Palate in Southern Thailand

Population-Based Study of Prevalence of Cleft Lip/Palate in Southern Thailand

ICD‐10 impact on ascertainment and accuracy of oral cleft cases as recorded by the Brazilian national live birth information system

Associations between cough medications containing dextromethorphan or guaifenesin and major structural birth defects

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