The Birth of the Red Blood Cell: Dynamics of Erythroid Enucleation in the Bone Marrow Niche

Newton, Lucas M; Wölwer, Christina B.; Lim, Krystle Y.B.; Hawkins, Edwin D.; Humbert, Patrick O.

doi:10.1182/blood-2022-165991

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“…Although much attention has been given over the years to defining a hierarchical view of haematopoiesis, its spatial organization was much less understood until more recently [6,7 ▪▪ ]. The haematopoietic niche can be described as the perivascular space wherein haematopoietic stem cells reside, most often associated with the sinusoidal blood vessels in the bone marrow [8].…”

Section: Redefining the Concept Of The Erythoblastic Niche Into An Er...mentioning

confidence: 99%

Navigating the marrow sea towards erythromyeloblastic islands under normal and inflammatory conditions

Josselsohn

Barnes

Kalfa

et al. 2023

Current Opinion in Hematology

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Purpose of reviewTerminal erythroid differentiation occurs in specialized niches called erythroblastic islands. Since their discovery in 1958, these niches have been described as a central macrophage surrounded by differentiating erythroblasts. Here, we review the recent advances made in the characterization of these islands and the role they could play in anaemia of inflammation.Recent findingsThe utilization of multispectral imaging flow cytometry (flow cytometry with microscopy) has enabled for a more precise characterization of the niche that revealed the presence of maturing granulocytes in close contact with the central macrophage. These erythromyeloblastic islands (EMBIs) can adapt depending on the peripheral needs. Indeed, during inflammation wherein inflammatory cytokines limit erythropoiesis and promote granulopoiesis, EMBIs present altered structures with increased maturing granulocytes and decreased erythroid precursors.SummaryRegulation of the structure and function of the EMBI in the bone marrow emerges as a potential player in the pathophysiology of acute and chronic inflammation and its associated anaemia.

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Section: Redefining the Concept Of The Erythoblastic Niche Into An Er...mentioning

confidence: 99%

Navigating the marrow sea towards erythromyeloblastic islands under normal and inflammatory conditions

Josselsohn

Barnes

Kalfa

et al. 2023

Current Opinion in Hematology

View full text Add to dashboard Cite

show abstract

The Birth of the Red Blood Cell: Dynamics of Erythroid Enucleation in the Bone Marrow Niche

Cited by 1 publication

References 0 publications

Navigating the marrow sea towards erythromyeloblastic islands under normal and inflammatory conditions

Navigating the marrow sea towards erythromyeloblastic islands under normal and inflammatory conditions

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