The biosynthesis of guanidinosuccinic acid by perfused rat liver.

Pérez, Guido O.; Rey, Amayelle; Schiff, Eugene R.

doi:10.1172/jci108340

Cited by 34 publications

(16 citation statements)

References 8 publications

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“…HPLC has been used for the analysis of arginine and its metabolites (15,19,20). The HPLC examination of the acid-soluble substances demonstrated that the distribution of radioactive acid-soluble substances depend on the organs and the intervals after injection.…”

Section: Resultsmentioning

confidence: 99%

“…The results by HPLC showed that urea and guanidinosuccinic acid were the principal metabolites in the organs examined. Guanidinosuccinic acid, has been detected in the liver of uremia rats (21) and in the liver and kidney of normal rats (19,20), is formed from transamidination of arginine to aspartic acid (20). On the other hand, the interorgan flow of arginine is an important issue in relation to the urea cycle and critical nature of the extrahepatic economy (4).…”

Section: Resultsmentioning

confidence: 99%

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Distribution and metabolic fate of radioactive carbon from L-(U-14C)arginite administered into mice.

Goto

1989

Acta Histochem. Cytochem

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Distribution and metabolic fate of radioactive carbon from L-(U-14C)arginite administered into mice.

Goto

1989

Acta Histochem. Cytochem

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“…The metabolic pathways of guanidinosuccinate remain incompletely understood [6,[29][30][31]. The relation between guanidino compound metabolism and inflammation has not been investigated thoroughly.…”

Section: Discussionmentioning

confidence: 99%

“…Guanidinosuccinate and guanidinopropionate can inhibit neutrophil superoxide production [30,32] and a mixture of guanidino compounds was found to suppress the natural killer cell response to interleukin-2 [33].…”

Section: Discussionmentioning

confidence: 99%

Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status

Taes

Marescau

Vriese

et al. 2007

Nephrology Dialysis Transplantation

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Background. Specific guanidino compounds have been described as uraemic toxins and their concentrations are increased in renal failure due to dimished glomerular filtration, whereas the guanidino compound creatine is used as a performance-enhancing substance in athletes. The present study investigates the effects of creatine supplementation on plasma guanidino compounds in a chronic haemodialysis population. Methods. Twenty male haemodialysis patients were included in a placebo-controlled cross-over trial. Patients were treated with creatine (2 g/day) or placebo during two treatment periods of 4 weeks, separated by a washout of 4 weeks. Plasma guanidino compounds and routine biochemical parameters were determined, as well as the prognostic inflammatory and nutritional index (PINI). Results. Upon creatine supplementation, guanidinoacetate concentrations decreased by 15%, due to inhibition of creatine synthesis. Concentrations of α-keto-δ-guanidinovaleric acid increased three-fold and argininic acid concentrations doubled. Guanidinosuccinate concentrations did not change, but correlated inversely with CRP (r = −0.736; P = 0.001), PINI-score (r = −0.716; P = 0.002) and correlated positively with plasma urea concentration (r = 0.54; P = 0.02). Conclusions. Creatine supplementation in haemodialysis patients significantly altered the concentration of specific guanidino compounds. Guanidinosuccinate correlated positively with plasma urea and negatively with inflammation markers.

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“…In cytoplasm, aspartic acid is used as cosubstrate of arginino-succinate synthetase, and in the pyrimidine synthesis. It is also used in the biosynthesis of guanidinosuccinic acid (16). The reason why^the aspartic acid values in erythrocytes of patients with hyperargininemia fall to the plasma values is not yet clear.…”

Section: Discussionmentioning

confidence: 99%

Arginase and Free Amino Acids in Hyperargininemia: Leukocyte Arginine as a Diagnostic Parameter for Heterozygotes

Marescau¹,

Pintens²,

Löwenthal³

et al. 1979

Clinical Chemistry and Laboratory Medicine

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Summary: Arginase activity and free amino acids were measured in plasma, erythrocytes and leukocytes of patients with hyperargininemia and in controls. There is no arginase activity in the leukocytes and erythrocytes of homozygous patients; in heterozygotes it is normal to low. The activity is 50 to 100 times higher in leukocytes than in erythrocytes. In controls as well as in patients and heterozygotes, the amino acid concentrations are higher in leukocytes than in plasma and erythrocytes. In addition to the increased arginine in the three blood compartments (the result of an arginase deficiency), there is also an obvious decrease of aspartic acid in the erythrocytes of the patients. The arginine concentration in leukocytes of heterozygotes is as high as in homozygotes and can therefore be used as a diagnostic parameter for heterozygotes.

show abstract

The biosynthesis of guanidinosuccinic acid by perfused rat liver.

Cited by 34 publications

References 8 publications

Distribution and metabolic fate of radioactive carbon from L-(U-14C)arginite administered into mice.

Distribution and metabolic fate of radioactive carbon from L-(U-14C)arginite administered into mice.

Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status

Arginase and Free Amino Acids in Hyperargininemia: Leukocyte Arginine as a Diagnostic Parameter for Heterozygotes

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