2017
DOI: 10.1158/0008-5472.can-17-0994
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The Biology of Cancer Exosomes: Insights and New Perspectives

Abstract: Exosomes are a subclass of extracellular vesicles involved in intercellular communication that are released by all cell types, including cancer cells. Cancer exosomes carry malignant information in the form of proteins, lipids, and nucleic acids that can reprogram recipient cells. Exosomes have emerged as putative biological mediators in cancer contributing to major steps of disease progression. A leading role exists for cancer exosomes in specific aspects of tumor progression: modulation of immune response, t… Show more

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Cited by 439 publications
(330 citation statements)
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References 82 publications
(101 reference statements)
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“…Exosomes, which arise from the endosomal pathway, and microvesicles have been reported to transport mRNAs, ncRNAs, including miRNAs, lncRNAs, and circRNAs, as a mechanism of intercellular communication (Kim et al 2017a). Cancer exosomes modulate the immune response and the tumor environment locally and at a distance, i.e., metastasis to secondary sites, by horizontal cargo transfer to recipient cells (Ruivo, et al 2017). In a recent study, isolated exosomes from tamoxifen-resistant LCC2 BCa cells were shown to contain ~25-fold higher lncRNA UCA1 compared to parental MCF-7 cells and incubation of MCF-7 cells with exosomes from LCC2 cells resulted in decreased growth inhibition by tamoxifen ), although no uptake of UCA1 or other lncRNAs or miRNAs was examined.…”
Section: Lncrnas In Circulationmentioning
confidence: 99%
“…Exosomes, which arise from the endosomal pathway, and microvesicles have been reported to transport mRNAs, ncRNAs, including miRNAs, lncRNAs, and circRNAs, as a mechanism of intercellular communication (Kim et al 2017a). Cancer exosomes modulate the immune response and the tumor environment locally and at a distance, i.e., metastasis to secondary sites, by horizontal cargo transfer to recipient cells (Ruivo, et al 2017). In a recent study, isolated exosomes from tamoxifen-resistant LCC2 BCa cells were shown to contain ~25-fold higher lncRNA UCA1 compared to parental MCF-7 cells and incubation of MCF-7 cells with exosomes from LCC2 cells resulted in decreased growth inhibition by tamoxifen ), although no uptake of UCA1 or other lncRNAs or miRNAs was examined.…”
Section: Lncrnas In Circulationmentioning
confidence: 99%
“…A multitude of different effects of exosomes was reported. In cancer, exosomes reprogram tissue to allow growth of metastases, act as decoys to escape the immune system, or spread factors conferring resistance to drugs used in chemotherapy (Chiarugi & Cirri, 2016; Desrochers et al, 2016; Dorsam, Reiners, & von Strandmann, 2018; Dreyer & Baur, 2016; Kahlert & Kalluri, 2013; Kalluri, 2016; Ruivo, Adem, Silva, & Melo, 2017; S, Mager, Breakefield, & Wood, 2013; M. Silva & Melo, 2015; Steinbichler, Dudas, Riechelmann, & Skvortsova, 2017; Weidle, Birzele, Kollmorgen, & Ruger, 2017; H.…”
Section: Got Exosomes: What’s (Really) In Your Prep?mentioning
confidence: 99%
“…Exosomes are small, 30‐100 nm membrane‐bound vesicles, secreted by virtually all cell types including tumor cells (Ruivo, Adem, Silva, & Melo, 2017; Wahlgren et al, 2012). They are believed to partake in cellular communications through delivering their contents to the recipient cells, such as functional proteins and microRNAs (miRNAs, miRs; Nakamura et al, 2017; Samanta et al, 2017).…”
Section: Introductionmentioning
confidence: 99%