The Biology of Bone Metastasis

Esposito, Mark; Guise, Theresa A.; Kang, Yibin

doi:10.1101/cshperspect.a031252

Cited by 126 publications

(111 citation statements)

References 125 publications

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“…The osteoclastic bone resorption is significant to make the skeleton a permissive environment in most bone metastases 60 . Osteoclasts, the only cells capable of bone resorption, derived from myeloid lineage, were reported to be controlled by RANKL, PTHrP and Jagged 1 61‐64 . In a recent report, LIGHT (tumour necrosis factor superfamily member 14, TNFSF14), derived from monocytes, was shown to promote osteolysis in NSCLC bone metastases and could be a new therapy target 65 .…”

Section: Discussionmentioning

confidence: 99%

“…In a recent report, LIGHT (tumour necrosis factor superfamily member 14, TNFSF14), derived from monocytes, was shown to promote osteolysis in NSCLC bone metastases and could be a new therapy target 65 . RANKL can be secreted by osteoblast lineages or stromal cells, and PTHrp can be derived from tumour cells 61,66‐68 . Although PTHrP and RANKL have been reported to be associated with NSCLC bone metastasis, 69,70 therapy efficiency of treatment targeting RANKL on NSCLC bone metastases is extremely limited.…”

Section: Discussionmentioning

confidence: 99%

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BMP2 signalling activation enhances bone metastases of non‐small cell lung cancer

Huang

Yun

et al. 2020

J Cellular Molecular Medi

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Distant metastases occur when non‐small cell lung cancer (NSCLC) is at late stages. Bone metastasis is one of the most frequent metastases of NSCLC and leads to poor prognosis. It has been reported that high expression of BMP2 in NSCLC correlates with poor survival, but whether BMP2 contributes to NSCLC bone metastasis remains largely unknown. The activation of BMP signalling is found in metastatic bone tumours of mice Lewis lung carcinoma and predicts poor survival in human NSCLC. BMP2 signalling activation can enhance bone metastasis of Lewis lung carcinoma. Moreover, BMP2 secreted by stroma fibroblasts can promote the migration and invasion of NSCLC cells. Besides, in combination with pre‐osteoblast and LLCs, BMP2 could enhance the differentiation of macrophages into osteoclasts to play roles in the osteolytic mechanism of NSCLC bone metastasis. Interestingly, NSCLC cells can also enrich BMP2 to pre‐osteoblasts to function in the osteoblastic mechanism. Our results firstly demonstrate the detailed mechanisms about what roles BMP2 signalling play in enhancing NSCLC bone metastases. These findings provide a new potential therapy choice for preventing bone metastases of NSCLC via the inhibition of BMP2 signalling.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

BMP2 signalling activation enhances bone metastases of non‐small cell lung cancer

Huang

Yun

et al. 2020

J Cellular Molecular Medi

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“…First, the bone-metastatic potential may depend on host factors that determine the BM metastasis niche (e.g., cellular and secreted components of the local environment, such as bone stromal cells, osteoblasts, osteoclasts, immune cells, growth factors, cyto-and chemokines, etc.). These niche factors have been shown to control seeding, dormancy, and outgrowth of BM metastases [32]. During in vitro cultivation, the niche factors are absent so that the gene expression profile of BM metastasis cells may revert to that of the primary tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Modeling Spontaneous Bone Metastasis Formation of Solid Human Tumor Xenografts in Mice

Labitzky

Baranowsky

Maar

et al. 2020

Cancers

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The majority of cancer-related deaths are due to hematogenous metastases, and the bone marrow (BM) represents one of the most frequent metastatic sites. To study BM metastasis formation in vivo, the most efficient approach is based on intracardiac injection of human tumor cells into immunodeficient mice. However, such a procedure circumvents the early steps of the metastatic cascade. Here we describe the development of xenograft mouse models (balb/c rag2-/- and severe combined immunodeficient (SCID)), in which BM metastases are spontaneously derived from subcutaneous (s.c.) primary tumors (PTs). As verified by histology, the described methodology including ex vivo bioluminescence imaging (BLI) even enabled the detection of micrometastases in the BM. Furthermore, we established sublines from xenograft primary tumors (PTs) and corresponding BM (BM) metastases using LAN-1 neuroblastoma xenografts as a first example. In vitro “metastasis” assays (viability, proliferation, transmigration, invasion, colony formation) partially indicated pro-metastatic features of the LAN-1-BM compared to the LAN-1-PT subline. Unexpectedly, after s.c. re-injection into mice, LAN-1-BM xenografts developed spontaneous BM metastases less frequently than LAN-1-PT xenografts. This study provides a novel methodologic approach for modelling the spontaneous metastatic cascade of human BM metastasis formation in mice. Moreover, our data indicate that putative bone-metastatic features get rapidly lost upon routine cell culture.

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“…Hal tersebut menggambarkan bahwa tulang berperan tidak hanya menjadi target namun juga sebagai sumber radiasi yang memaparkan radiasi kepada sumsum merah yang merupakan sumsum tulang. Dalam proses metastasis, sumsum merah juga berperan mengumpulkan sel-sel tumor dari hampir semua jenis kanker, dan metastasis tulang terbentuk di hematopoietik sumsum merah aktif [23]. Dan dari Izotop (summary product characteristic) [24], dosimetri 99m Tc-MDP produksi Institute of Isotope.Co.Ltd.…”

Section: Hasil Dan Pembahasanunclassified

STUDI AWAL ESTIMASI DOSIS INTERNAL 99mTc-MDP HASIL PRODUKSI PSTNT-BATAN PADA MANUSIA UNTUK DETEKSI METASTASIS DAN INFLAMASI TULANG BERBASIS UJI BIODISTRIBUSI HEWAN MODEL MENCIT

Islami

Hidayati

Wibawa

et al. 2019

gnd

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STUDI AWAL ESTIMASI DOSIS INTERNAL 99mTc-MDP HASIL PRODUKSI PSTNT-BATAN PADA MANUSIA UNTUK DETEKSI METASTASIS DAN INFLAMASI TULANG BERBASIS UJI BIODISTRIBUSI HEWAN MODEL MENCIT. Kanker adalah sel abnormal yang dapat menyebar sampai ke tulang. Pemeriksaan dapat dilakukan dengan bone-scan menggunakan radiofarmaka. PSTNT-BATAN Bandung melakukan penelitian radiofarmaka penyidik tulang yaitu MDP yang dapat ditandai dengan radionuklida teknesium-99m. Penelitian ini bertujuan memperoleh estimasi dosis internal radiofarmaka 99mTc-MDP sebagai penyidik metastasis dan inflamasi tulang untuk manusia berdasarkan biodistribusi radiofarmaka 99mTc-MDP produksi PSTNT-BATAN. Metode penelitian ini, uji biodistribusi dari penandaan MDP dengan teknesium-99m dengan interval waktu 2,4,6, dan 24 jam setelah penyuntikan melalui intravena ekor pada 12 hewan model mencit normal dengan dosis injeksi 5,44 MBq tiap mencit dengan kemurnian 98,49%±25,37.Hasil uji biodistribusi didapatkan persentase dosis injeksi pergram organ hewan yang dikonversi menjadi persentase dosis injeksi pergram organ manusia yang diinput pada software OLINDA/EXM untuk mendapatkan residence time dan estimasi dosis internal. Hasil estimasi dosis menggunakan OLINDA/EXM diperoleh nilai total estimasi dosis efektif 99mTc-MDP (mSv/MBq) untuk laki-laki dewasa 1,87E-03 sedangkan untuk wanita dewasa bernilai 2,24E-03. Hasil estimasi dosis radiofarmaka 99mTc-MDP produksi PSTNT-BATAN ini dapat digunakan sebagai panduan dosis organ pada saat akan diinjeksikan pada manusia.

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The Biology of Bone Metastasis

Cited by 126 publications

References 125 publications

BMP2 signalling activation enhances bone metastases of non‐small cell lung cancer

BMP2 signalling activation enhances bone metastases of non‐small cell lung cancer

Modeling Spontaneous Bone Metastasis Formation of Solid Human Tumor Xenografts in Mice

STUDI AWAL ESTIMASI DOSIS INTERNAL 99mTc-MDP HASIL PRODUKSI PSTNT-BATAN PADA MANUSIA UNTUK DETEKSI METASTASIS DAN INFLAMASI TULANG BERBASIS UJI BIODISTRIBUSI HEWAN MODEL MENCIT

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