The biology of adhesion formation in the peritoneal cavity

Braun, Kelli; Diamond, Michael P.

doi:10.1053/j.sempedsurg.2014.06.004

Cited by 73 publications

(74 citation statements)

References 28 publications

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“…Hypoxia leads to oxidative stress, anaerobic metabolism, formation of free radicals, and eventual adhesion formation. The high levels of free radicals initiate a cascade of inflammatory pathways 16,17. Many cellular and humoral factors affect the adhesion formation by influencing the process of fibrogenesis and fibrinolysis, including transforming growth factor-β1, vascular endothelial growth factor, and tumor necrosis factor-alpha 16,18.…”

Section: Discussionmentioning

confidence: 99%

“…The high levels of free radicals initiate a cascade of inflammatory pathways 16,17. Many cellular and humoral factors affect the adhesion formation by influencing the process of fibrogenesis and fibrinolysis, including transforming growth factor-β1, vascular endothelial growth factor, and tumor necrosis factor-alpha 16,18. Several types of inflammatory cells including granulocytes, lymphocytes, macrophages, and fibroblasts actively participate in the process of adhesion formation 18.…”

Section: Discussionmentioning

confidence: 99%

“…ORC was the first generation of mechanical barrier agents used to cover the peritoneum, and has been approved by the US Food and Drug Administration (FDA) for prevention of adhesion development 4,16. ORC is composed of ORC fabric that provides a continuous coat over damaged tissues within 8 hours and will be completely absorbed within 2 weeks 15,22.…”

Section: Discussionmentioning

confidence: 99%

“…Although in adherence to microsurgical principles, minimally invasive surgery is widely accepted, it is not sufficient to prevent adhesion formation/reformation 16. Therefore, in addition to applying meticulous surgical techniques and principles of microsurgery, proper use of anti-adhesion agents could reduce the incidence of adhesion formation/reformation 1.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Hyaluronate acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat models

Zhang

Liu

Yang

et al. 2016

DDDT

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Postsurgical adhesion formation is the most common complication in abdominal and pelvic surgery. Adhesiolysis is the most commonly applied treatment for adhesion formation but is often followed by adhesion reformation. Therefore, an efficient strategy should be adopted to solve these problems. This study aimed to explore whether hyaluronic acid and oxidized regenerated cellulose (ORC) could prevent adhesion formation and reformation. Thirty female Sprague Dawley rats were randomly divided into three groups (n=10 each) and subjected to different treatments during the first and second surgery. The control group was treated with isotonic sodium chloride, the ORC group was treated with ORC (1.5×1 cm), and the medical sodium hyaluronate (MSH) group was treated with 1% MSH (0.5 mL). At 2 weeks after the first surgery, adhesion scores in the MSH group (1.90±0.99) and the ORC group (1.40±0.97) were significantly lower than those in the control group (3.00±0.82) (P=0.005). Similarly, 2 weeks after the second surgery, adhesion scores in the MSH group (2.00±0.82) and the ORC group (1.50±1.27) were significantly lower than those in the control group (3.50±0.53) (P=0.001). In addition, body weights in the MSH group and the ORC group did not change significantly, whereas the control group showed a consistent decrease in body weight during the experiment. Histological examination revealed that inflammatory infiltration was involved in both adhesion formation and reformation. In conclusion, hyaluronic acid and ORC were both efficient in reducing adhesion formation and reformation in the rat model.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Hyaluronate acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat models

Zhang

Liu

Yang

et al. 2016

DDDT

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“…Peritoneāli saaugumi tiek definēti kā patoloģiski fibrozi savienojumi, kas saista vēdera dobuma orgānus savā starpā vai ar vēdera dobuma sienu (Braun & Diamond, 2014).…”

Section: Saaugumu Raksturojumsunclassified

Intraabdominālu saaugumu veidošanās un norises kompleksie morfopatoģenētiskie aspekti bērniem līdz gada vecumam. Promocijas darbs

Junga¹

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ANOTĀCIJAIntraabdomināli saaugumi ir fibrozi savienojumi starp vēdera dobuma orgāniem un/vai vēdera dobuma orgāniem un vēdera dobuma sienu. Tie var būt iegūti vai iedzimti. Iegūtus saaugumus galvenokārt iedala iekaisuma izraisītos un postoperatīvos saaugumos. Savukārt iedzimtus saaugumus saista ar vēdera dobuma embrionālās attīstības traucējumiem un/vai pat ar embrioģenēzes ģenētisku defektu. Intraabdomināli saaugumi var būt asimptomātiski, bet tie var būt arī tādas bīstamas komplikācijas kā intestinālas obstrukcijas cēlonis. Intraabdominālu saaugumu morfopatoģenēze ir komplekss process, kurš tiek raksturots ar ekstracelulārās matrices uzkrāšanos, audu hipoksiju un iekaisuma klātbūtni.Pētījuma mērķis bija noteikt un aprakstīt morfopatoģenētiskos faktorus, kas saistīti ar intraabdominālu saaugumu veidošanos un norisi, kā arī aprakstīt to savstarpējo mijiedarbību.Pētījumā tika iekļauti 50 saaugumu audu paraugi no 49 pacientiem ar pilnīgu vai daļēju kuņģa zarnu trakta necaurejamību un astoņu kontroles vēderplēves audu materiāls, kas iegūts, veicot cirkšņa trūces plastiku. Visi audu paraugi tika iegūti no pacientiem vecumā līdz vienam gadam.

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Dual Dynamic Crosslinked Hydrogel Patch Embodied with Anti‐Bacterial and Macrophage Regulatory Properties for Synergistic Prevention of Peritendinous Adhesion

Yao,

Hu,

et al. 2024

Adv Funct Materials

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The occurrence of peritendinous adhesion, which hampers the quality and function of the healed tendon, is strongly linked to oxidative stress, inflammatory, and infection that occur after surgery. Tendon damage and repair provide a considerable obstacle for regenerative medicine owing to the absence of patches that possess comprehensive functionality, including self‐healing capacity, anti‐inflammatory and anti‐bacterial properties, as well as tissue repair guidance. A dual dynamic crosslinked network is created by coordination bonds between catechol groups in protocatechuic aldehyde (PA) and Fe3+, as well as a dynamic Schiff base reaction between amino groups in hyaluronic acid‐adipic acid dihydrazide (HA‐ADH) and aldehyde groups in PA. The HA‐ADH@PA/Fe hydrogel exhibits self‐healing ability, tissue adhesion, anti‐bacterial activity, regulation of macrophage polarization via the NF‐κB signaling, oxidative stress elimination, and anti‐inflammation. In addition, a dual‐layer Janus patch is created, taking inspiration from the anatomy and disease progression of tendon adhesion. The inner layer of the patch, which is in direct contact with the operated tendon, is a multifunctional HA‐ADH@PA/Fe hydrogel, encircled further by a poly(ɛ‐caprolactone) (PCL) electrospinning membrane outer layer facing the surrounding tissue. The PCL@HA‐ADH@PA/Fe hydrogel patch reduced tendon adhesion and supported tissue regeneration by stimulating macrophages polarization into an anti‐inflammatory phenotype and resolving both local and systemic inflammation. This research showcased the PCL@HA‐ADH@PA/Fe hydrogel patch as an alternative therapeutic method for preventing the development of adhesions around tendons.

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The biology of adhesion formation in the peritoneal cavity

Cited by 73 publications

References 28 publications

Hyaluronate acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat models

Hyaluronate acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat models

Intraabdominālu saaugumu veidošanās un norises kompleksie morfopatoģenētiskie aspekti bērniem līdz gada vecumam. Promocijas darbs

Dual Dynamic Crosslinked Hydrogel Patch Embodied with Anti‐Bacterial and Macrophage Regulatory Properties for Synergistic Prevention of Peritendinous Adhesion

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