The Biology and Chemistry of Hyperlipidemia

Jain, Kishor S.; Kathiravan, M. K.; Somani, Rahul; Shishoo, C. J.

doi:10.1002/chin.200738269

Cited by 22 publications

(27 citation statements)

References 1 publication

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“…Increased blood lipid levels have long been suspected as an increased risk for CVD, especially LDLs [95]. One mechanism that is linked with atherosclerosis is the presence of oxidated LDL [96].…”

Section: Lipid Metabolismmentioning

confidence: 99%

An Update on the Health Benefits of Green Tea

Reygaert

2017

Beverages

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Abstract:Green tea, which is produced from the leaves of the Camellia sinensis plant, is one of the most popular beverages worldwide. Over the past 30 years or more, scientists have studied this plant in respect to potential health benefits. Research has shown that the main components of green tea that are associated with health benefits are the catechins. The four main catechins found in green tea are: (−)-epicatechin (EC), (−)-epicatechin-3-gallate (ECG), (−)-epigallocatechin (EGC), and (−)-epigallocatechin-3-gallate (EGCG). Of these four, EGCG is present in the largest quantity, and so has been used in much of the research. Among the health benefits of green tea are: anticarcinogenic, anti-inflammatory, antimicrobial, and antioxidant properties, and benefits in cardiovascular disease and oral health. Research has been carried out using various animal models and cells lines, and is now more and more being carried out in humans. This type of research will help us to better understand the direct benefits of green tea. This review will focus primarily on research conducted using human subjects to investigate the health benefits of green tea.

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Section: Lipid Metabolismmentioning

confidence: 99%

An Update on the Health Benefits of Green Tea

Reygaert

2017

Beverages

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“…A 1% drop in serum cholesterol reduces the risk of cardiac heart disease by 2% 1 . The increased blood level of total cholesterol, triglyceride, low density lipoprotein, very low density lipoprotein and Lowered level of High density lipoprotein has been identified in development of hyperlipidemia.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated serum cholesterol levels leading to atherosclerosis can cause coronary heart disease 1 . Coronary arterial diseases are responsible for more deaths than all other associated causes combined.…”

Section: Introductionmentioning

confidence: 99%

Antihyperlipidemic Activity of Suaeda Maritima (L.) Dumortier Stem in Triton Induced Hyperlipidemic Rats

Singh¹,

Mann²,

Sharma³

2013

Int. J. Res. Ayurveda Pharm.

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The present study was designed to investigate the hypolipidemic effect of Suaeda maritima (L.) Dumortier stem extracts in triton induced hyperlipidemia. Aqueous and alcoholic extracts of aerial parts of Suaeda maritima (L.) Dumortier were administered at dose 150 mg/kg and 300 mg/kg/day orally, respectively. Simultaneous administrations of stem extracts of Suaeda maritima (L.) Dumortier significantly prevent the rise in serum levels of total cholesterol (TC), triglyceride (TG), Low density lipoprotein (LDL) and very low density lipoprotein (VLDL) whereas significant increases in the level of high density lipoprotein (HDL) in both secretary and excretory phase. The Suaeda maritima (L.) Dumortier methanol extract of stem at dose 300mg/kg body weight orally showed significant antihyperlipidemic activity which may be due to the presence of triterpenoids and sterols found in the preliminary phytochemical screening.

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“…There are various types of hyperlipidemia depending on which lipid levels are high in the blood." [8] Depression and hyperlipidemia are common conditions that often coexist and may clinically interact with each other. Depression has a negative impact on medication adherence.…”

Section: Introductionmentioning

confidence: 99%

A study on the effect of atorvastatin on the pharmacokinetic and antidepressant activity of fluoxetine

Bhattarai¹,

Swamy²,

Baral³

et al. 2017

Natl J Physiol Pharm Pharmacol

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Background: Polypharmacy is of wide concern in drug interaction. It is the leading cause of adverse drug reaction, and consequently, increasing the possibility of hospitalization and escalating the cost of care. The incidence of coexisting depression and hyperlipidemia in patients is generally managed by providing numerous drugs for a longer period of time. Aims and Objectives: This study was conducted to observe the effect of atorvastatin on pharmacokinetic parameters of fluoxetine in healthy albino rabbits and to find possible interactions of atorvastatin on the antidepressant activity of fluoxetine using animal screening test. Materials and Methods: Two drugs: Fluoxetine and atorvastatin used concurrently were selected. Healthy male albino rabbits were used to determine the effect of atorvastatin on fluoxetine addressing its pharmacokinetic parameters, whereas rats and mice were used to assess the antidepressant activity of fluoxetine. Two animal models were used to determine its antidepressant activity. Forced swim test (FST) and tail suspension test (TST) were employed in exploring antidepressant activity. High-performance liquid chromatography was used to estimate fluoxetine concentration. Results: The concentration of serum fluoxetine showed slight increment after the atorvastatin treatment for 7 days at 2

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The Biology and Chemistry of Hyperlipidemia

Cited by 22 publications

References 1 publication

An Update on the Health Benefits of Green Tea

An Update on the Health Benefits of Green Tea

Antihyperlipidemic Activity of Suaeda Maritima (L.) Dumortier Stem in Triton Induced Hyperlipidemic Rats

A study on the effect of atorvastatin on the pharmacokinetic and antidepressant activity of fluoxetine

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